Pharmacological effect of Kalpaamruthaa on renal and cardiac damage induced by ingestion of aflatoxin B1 studied in wistar rats

Kanchana, Karvannan; Hedhayathullahkhan, Haseena Banu; Vedagiri, Aishwarya; Shanthi, Palanivelu; Sachdanandam, Panchanatham

doi:10.1016/j.bionut.2012.10.004

Cited by 7 publications

(12 citation statements)

References 67 publications

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“…In the present study, vitamin C was significantly reduced in the milling workers compared to their controls. In agreement with the current results, Kanchana et al [27] found a significant reduction in vitamin C levels in AFB1-administered rat, and they defined this as a responsible for increased lipid peroxidation which resulting in oxidative stress observed during aflatoxicosis.…”

Section: Discussionsupporting

confidence: 92%

“…The antioxidant enzyme SOD plays an important role in the elimination of ROS derived from the peroxidative process, SOD removes superoxide by converting it to H 2 O 2 [27], and similarly, this could also explain the significant elevation of SOD of the milling workers compared to their controls in the current research. Contrary to the current result, Alpsoy et al [30] found that in human lymphocytes, AFB1 significantly decreased the activities of SOD.…”

Section: Discussionmentioning

confidence: 64%

“…One of the manifestations of AFB 1 -induced toxicity is aflatoxicosis, which has been associated with enhanced ROS generation and oxidative stress [27]. Previous researches revealed that the effect of exposure to AFB1 on the levels of MDA is a dose dependent manner in human lymphocytes cultured in vitro [28], and in wheat milling workers [29].…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Saad-Hussein¹,

Abdalla²,

Shousha³

et al. 2014

Open Access Maced J Med Sci

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Aim: The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers. Materials and Methods:Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects.Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion:The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Saad-Hussein¹,

Abdalla²,

Shousha³

et al. 2014

Open Access Maced J Med Sci

View full text Add to dashboard Cite

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“…They are also known to cause high mortality in humans and animals, such as cattle [6][7][8][9]. Since the kidneys are the primary excretory Use your device to scan and read the article online pathway for some toxins, the high sensitivity of this organ to the toxins is crucial, thus they are well known for their nephrotoxicity [10][11][12]. According to studies, aflatoxins' metabolites exert toxicity to the kidney nephrons even before being excreted in the urine [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice

Zamir-Nasta

Ahmadi

Yazdkhasti

et al. 2021

IJT

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Background: Among aflatoxins, the subtype aflatoxin G1 is one of the most toxic, commonly found in cereals, legumes, dairy and non-alcoholic beers. Aflatoxins have been known as nephrotoxic compounds. In this study, changes in the expression of aquaporin-1, the histopathology of renal tissue and plasma biochemical factors after exposure to aflatoxin G1 were investigated in mice. Methods: Twenty-four adult male mice (weighing 20±2 g) were divided into four groups of six. The control group received the vehicle (0.2 ml) and the three experimental groups were injected intraperitoneally with aflatoxin G1 at 20 μg/kg for 7, 15 or 35 days, respectively. On days 7, 15 and 35, blood samples were drawn from the mice for biochemical analysis of plasma and the kidney tissues were sampled for real-time PCR and histopathological studies. Results: The real PCR results showed a reduction in aquaporin-1 expression in the experimental groups compared to those in the controls (P<0.05). Also, the plasma concentrations of urea and creatinine were significantly increased in the experimental groups compared to those in the controls (P<0.05). Also, the serum sodium and potassium levels had decreased significantly compared to the controls (P<0.05). Various damages were observed in the ureters and glomeruli among the experimental groups compared to those in the controls. Conclusion: Aflatoxin G1 had adverse effects on the renal tissue by reducing the expression of aquaporin-1. Subsequently, there were biochemical manifestations in the serum, consisting of changes in the concentrations of urea, creatinine, sodium and potassium, confirming the histopathological toxicity of aflatoxin G1.

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“…However, the mechanisms of ROS generation induced by AFB1 have not been completely elucidated [6,8]. One of the manifestations of AFB 1induced toxicity is aflatoxicosis, which has been associated with enhanced ROS generation and oxidative stress [27]. Previous researches revealed that the effect of exposure to AFB1 on the levels of MDA is a dose dependent manner in human lymphocytes cultured in vitro [28], and in wheat milling workers [29].…”

Section: Hepatotoxicitymentioning

confidence: 99%

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

et al. 2014

View full text Add to dashboard Cite

The study aimed to estimate oxidative role of aflatoxin B1 (AFB1) on the liver in wheat milling workers.Materials and Methods: Case-control study was conducted to compare between the levels of AFB1/albumin (AFB1/alb), liver enzymes (ALT, AST, GGT, and ALP), P53, MDA, GST, SOD, zinc and vitamin C in 35 wheat milling workers and 40 control subjects.Results: Statistical analysis revealed that ALT, AST, GGT, ALP, P53, MDA, GST and SOD in workers were significantly elevated compared to their controls. In the milling workers, there were significant correlations between MDA levels and the levels of AST, GGT, and P53, while, P53 was inversely correlated with GST and SOD activities. There were significant correlations between Zn levels and GGT, GST and SOD activities, between vitamin C and GST activities, and vitamin C inversely correlated with MDA. Conclusion:The present study concluded that the oxidative stress of AFB1 elevated the MDA and the liver enzymes in wheat milling workers. GST has a crucial role in the detoxification of aflatoxin and SOD as a scavenger antioxidant increased in the workers to overcome the oxidative toxic effects of AFB1 on the liver of the workers, and roles of Zn and vitamin C were significant in activation of these processes.

show abstract

Pharmacological effect of Kalpaamruthaa on renal and cardiac damage induced by ingestion of aflatoxin B1 studied in wistar rats

Cited by 7 publications

References 67 publications

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice

Oxidative Role of Aflatoxin B1 on the Liver of Wheat Milling Workers

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