Pharmacological effects of biotin

Fernández-Mejía, Cristina

doi:10.1016/j.jnutbio.2005.03.018

Cited by 78 publications

(61 citation statements)

References 41 publications

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“…Hepatic glucokinase activity is subnormal in diabetes, and glucokinase may also be decreased in the β cells of individuals with type 2 DM [64]. In supra-physiological concentrations, biotin promotes the transcription and translation of the glucokinase gene in hepatocytes; and more recent evidence indicates that biotin increases glucokinase activity in pancreatic islet cells [34,65].…”

Section: Discussionmentioning

confidence: 99%

“…Biotin, a water-soluble B vitamin, plays an essential role in carbohydrate and lipid metabolism [34]. Besides its role as a carboxylase prosthetic group, biotin regulates the expression of genes important for metabolism.…”

Section: Introductionmentioning

confidence: 99%

“…Biotin has stimulatory effects on genes whose actions favour glycaemic control, including pancreatic and hepatic glucokinases. It also suppresses the expression of hepatic phosphoenolpyruvate carboxykinase, a key gluconeogenic enzyme [34,35]. Biotin administration to diabetic rodents has been reported to improve glycaemic control [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

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Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

Albarracín

Fuqua

Evans³

et al. 2007

Diabetes Metabolism Res

104

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes

Albarracín

Fuqua

Evans³

et al. 2007

Diabetes Metabolism Res

104

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show abstract

“…In recent years it has been considered that supplementation with pharmacological doses of biotin also leads to endocrine, systemic, and metabolic actions [24,[40][41]. To our knowledge, there are no reports exploring the effect of biotin on vastus lateralis muscle carboxylases.…”

Section: Discussionmentioning

confidence: 99%

Differential effect of biotin on carboxylase activity and mice skeletal muscle metabolism

de¹,

Gutiérrez‐Ospina²,

Salcedo³

et al. 2013

ABB

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In mammalian skeletal muscle there are four carboxylases involved in several biochemical processes like gluconeogenesis, tricarboxylic acid cycle anaplerosis, metabolism of fatty acids and metabolism of various amino acids. It has been shown that biotin deficiency reduces body weight at the expense of muscular mass. When necessary, the liver uses skeletal muscle protein to provide glucose and amino acids to organs in need of such compounds. In this paper we analyzed carboxylase specific activities in hind limb skeletal muscle of 3 weeks old BALB/c male mice, at 0, 1, 4, 7, and 14 days of a specific diet with different biotin concentrations. Biotin was used at 0.0, 1.8 or 98.2 mg per kg of food; and was referred to as biotin deficient, sufficient and supplemented, respectively. Water and food supply and consumption by the three groups of mice were the same. Therefore, the observed effects were directly related to biotin ingestion. The body weight of biotin supplemented mice was the same as the body weight of mice in the biotin sufficient group, while biotin deficiency caused body weight reduction after 7 days of biotin depletion. We found that the total protein concentration in the vastus lateralis muscle is associated with the biotin content in the diet. After 7 days, the muscle total protein content was lower in mice of the biotin deficient group while it was higher in the mice from the biotin supplemented group (P < 0.001). Of the four analyzed enzymes, only pyruvate carboxylase specific activity was reduced in both cases: by consuming the supplemented diet and by the lack of this vitamin. Our data show that PC and muscle metabolism are differentially altered by both, biotin excess and biotin deficiency. The mechanisms of these effects are currently under investigation.

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“…& Brooks, P.H. 1983), and metabolism (Dakshinamurti, K. 2005;Fernandez-Mejia, C. 2005). Biotin exerts beneficial effects on endocrine pancreas physiology.…”

Section: Biotinmentioning

confidence: 99%