Pharmacological effects of latanoprost, prostaglandin E2, and F2 α on isolated rabbit ciliary artery

Ishikawa, Hitoshi; Yoshitomi, Takeshi; Mashimo, Kimiyo; Nakanishi, M.; Shimizu, Kimiya

doi:10.1007/s00417-001-0412-4

Cited by 21 publications

(12 citation statements)

References 18 publications

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“…The increase in POBF could be a direct effect of bimatoprost on choroidal circulation. Certain prostaglandins are known to cause vasodilation and interestingly ciliary artery relaxation has been shown to occur in rabbit eyes on topical latanoprost (28). Nicolea et al (29) postulated that though latanoprost a PGF 2 analog is known to cause vasoconstriction, it might also be having a selective vasodilatory effect on the choroidal circulation to explain the increase of ocular blood flow with latanoprost.…”

Section: Discussionmentioning

confidence: 98%

Effect of Changing From Concomitant Timolol Pilocarpine to Bimatoprost Monotherapy on Ocular Blood Flow and IOP in Primary Chronic Angle Closure Glaucoma

Agarwal

Gupta

Sihota

2003

Journal of Ocular Pharmacology and Therapeutics

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The aim of the present prospective masked study was to assess the effect of bimatoprost monotherapy on ocular blood flow and intraocular pressure (IOP) in eyes of primary chronic angle closure glaucoma patients already on concomitant timolol and pilocarpine. Thirty two patients of bilateral primary chronic angle closure glaucoma (PCACG) on topical timolol 0.5% twice a day and pilocarpine 2% three times daily were switched over to bimatoprost 0.03% once daily in both eyes. Intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) were recorded before and after starting bimatoprost and were followed up every four weeks for three months. Bimatoprost had statistically significant (p < 0.05) mean IOP reduction from 19.3 +/- 6.6 to 13.5 +/- 4.5 mmHg (30.5%) and there was improvement from 858 +/- 260 to 1261 +/- 321 microL/min (46.8%) in mean pulsatile ocular blood flow (p < 0.05). Conjunctival hyperemia (32%) was the most common adverse effect of bimatoprost. Bimatoprost 0.03% monotherapy improved ocular blood flow and provided a better diurnal IOP control than concomitant timolol-pilocarpine in eyes with primary chronic angle closure glaucoma and was found to be well tolerated.

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Section: Discussionmentioning

confidence: 98%

Effect of Changing From Concomitant Timolol Pilocarpine to Bimatoprost Monotherapy on Ocular Blood Flow and IOP in Primary Chronic Angle Closure Glaucoma

Agarwal

Gupta

Sihota

2003

Journal of Ocular Pharmacology and Therapeutics

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“…However, the underlying pharmacological mechanism is unclear. We therefore investigated the underlying mechanism of these drugs on vascular smooth muscles [6][7][8][9][10][11][12]. We examined whether these drugs relaxed the ciliary arteries by different mechanisms, such as nitric oxide (NO) release and inhibition of voltage-dependent or -independent calcium entry.…”

Section: Introductionmentioning

confidence: 99%

Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

2011

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“…Depending on the drug or formulation used, PGAs have been reported to increase, decrease, or not affect ocular blood flow. However, the reports are conflicting, with opposing results in some cases (19,20) . In the work presented here, both tafluprost BAK-free and travoprost BAK significantly reduced the RI of the OA in rabbits.…”

Section: Discussionmentioning

confidence: 99%

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

Giannico¹,

Lima²,

Shaw³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Universidade Federal do Paraná, protocol #011/2011. ABSTRACTPurpose: The aim of this study was to investigate the effects of prostaglandin analogs on blood flow in the ophthalmic artery of clinically healthy rabbits. Methods: Fifty-five clinically healthy New Zealand white rabbits were divided into six groups, and the left eyes were treated for four weeks with the preservative benzalkonium chloride (BAK) only or a topical formulation of different prostaglandin analogs (bimatoprost BAK, tafluprost BAK-free, travoprost BAK, travoprost POLYQUAD, and latanoprost BAK). Color Doppler imaging was performed before and after the treatments. The mean values of the peak systolic velocity (PSV) and end diastolic velocity and the resistive index (RI) were calculated. Statistical analysis was performed to compare the differences pre-and post-treatment for each drug and post-treatment among the drugs. Results: The prostaglandin analogs did not affect PSV. Bimatoprost BAK, travoprost POLYQUAD, and latanoprost BAK did not change RI. Tafluprost BAK-free and travoprost BAK therapy resulted in similar reductions in RI. No significant differences pre-and post-treatment were found when BAK was administered alone. Conclusion:The prostaglandin analogs tafluprost BAK-free and travoprost BAK improved blood flow in the ophthalmic artery in healthy New Zealand white rabbits, which suggests that these drugs enhance the prevention of the progression the progression of glaucoma. Keywords

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Pharmacological effects of latanoprost, prostaglandin E2, and F2 α on isolated rabbit ciliary artery

Abstract: These results indicate that latanoprost and PGE2 relaxed rabbit ciliary artery to different degrees. The relaxation provoked by latanoprost was not dependent on endothelium and was not caused by intrinsic PG, CGRP or nitric oxide. The mechanism of this relaxation is not yet clear.

Cited by 21 publications

References 18 publications

Effect of Changing From Concomitant Timolol Pilocarpine to Bimatoprost Monotherapy on Ocular Blood Flow and IOP in Primary Chronic Angle Closure Glaucoma

Effect of Changing From Concomitant Timolol Pilocarpine to Bimatoprost Monotherapy on Ocular Blood Flow and IOP in Primary Chronic Angle Closure Glaucoma

Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

Effects of prostaglandin analogs on blood flow velocity and resistance in the ophthalmic artery of rabbits

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