Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats

Das, PrabhatK; Pillai, Sujit; Kar, Dattatreya; Pradhan, Debasish; Sahoo, Sabuj

doi:10.4103/0019-5359.104788

Cited by 14 publications

(11 citation statements)

References 5 publications

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“…Surprisingly, the activity of the extract was higher at the dose of 250 mg/kg when compared with the dose of 500 mg/kg. This agrees with the finding of Das et al [29] , who reported better efficacy of extract of Argemone mexicana at lower dose than at higher dose. This effect may perhaps be attributed to the antioxidant action of the extract.…”

Section: Discussionsupporting

confidence: 93%

In vivoameliorative effects of methanol leaf extract ofLawsonia inermisLinn on experimentalTrypanosoma congolenseinfection in Wistar rats

Tauheed

Shittu

Сулейман

et al. 2016

International Journal of Veterinary Science and Medicine

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The aim of this study was to investigate the ameliorative effect of Lawsonia inermis Linn used traditionally against trypanosomosis. Twenty-five adult Wistar rats of both sex were individually infected intraperitoneally (IP) with 106Trypanosoma congolense per ml of blood. Following establishment of infection, the rats were randomly divided into five groups of 5 rats each. Rats in groups I, II, and III were treated with 125, 250 and 500 mg/kg of the extract, respectively, while rats in groups IV and V were treated with 3.5 mg/kg and 2 ml/kg of diminazene aceturate (DM) once and physiological buffered saline, respectively. All treatments except DM were given orally for 7 days IP. The antitrypanosomal effect of the plant was assessed by observing the level of parasitaemia daily, packed cell volume (PCV) weekly, erythrocyte osmotic fragility (EOF) and malondialdehyde (MDA) concentration on day 21. Phytochemical screening of the extract revealed the presence of alkaloids, carbohydrates, triterpenes, steroids, cardiac glycosides, saponins, tannins and flavonoids. The extract significantly (P < 0.05) reduced levels of parasitaemia at 250 mg/kg. PCV was higher (P > 0.05) in extract treated groups but significantly higher (P < 0.05) in group II at week 2 when compared to group V. Rats in group II had significantly lower values of EOF and MDA when compared with groups IV and V. Thus, the leaf of L. inermis has in addition to an antitrypanosomal effect against T. congolense in rats, an attenuating effect on the trypanosomosis pathology probably mediated via protection of the erythrocyte membrane against trypanosome-induced oxidative damage to the erythrocytes.

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Section: Discussionsupporting

confidence: 93%

In vivoameliorative effects of methanol leaf extract ofLawsonia inermisLinn on experimentalTrypanosoma congolenseinfection in Wistar rats

Tauheed

Shittu

Сулейман

et al. 2016

International Journal of Veterinary Science and Medicine

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“…Earlier studies have documented that A. mexicana is likely to contain benzylisoquinoline alkaloids such as benzophenanthridines, sanguarine, rotoberberines and protopines, protomexicine, mexitin dehydrocorydalmine, jatrorrhizine, columbamine, dl-tetrahydrocoptisine and dihydrocoptisine [21,22,23,24,25,26]. In an independent study on rodents [22], A. mexicana extracts were found to be effective in curing ulcers induced with cystamine.…”

Section: Discussionmentioning

confidence: 99%

“…In an independent study on rodents [22], A. mexicana extracts were found to be effective in curing ulcers induced with cystamine. In their work, Zhou et al, [27] used reseveratrol, whereas Mohan et al [28] used ethylgallate to study anti-proliferative effects on human oral squamous immortalized cell line KB.…”

Section: Discussionmentioning

confidence: 99%

Antifungal and Anticancer Potential of Argemone mexicana L.

Kharat

2016

Medicines

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Background: Medicinal plants are widely used to treat infectious diseases, metabolic disorders and cancer. Argemone mexicana L. (A. mexicana), commonly found on desolate land of Marathwada (Maharashtra, India) has been used to treat oral cavity infections. Methods: In this study, cold aqueous and methanolic extracts were prepared from A. mexicana stem and leaves. These extracts were tested for their antifungal and anticancer activities. The antifungal activity was tested using the agar well diffusion method, while the anticancer activity against immortalized cell lines was assessed by trypan blue assay. Results: It was observed that both cold aqueous and methanolic extracts of A. mexicana stem and leaves inhibited the growth of Mucor indicus, Aspergillus flavus, Aspergillus niger and Penicillum notatum. Antifungal activity of the extract was comparable to that of Amphoterecin-B. A. mexicana extracts had a cytotoxic effect on A549, SiHa and KB immortalized cell lines that were similar to that of berberine. Conclusion: The A. mexicana leaf and stems exhibit strong antifungal and anticancer potential.

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“…Argemone mexicana L. is a plant that contains numerous alkaloids and is widely used in traditional medicine. A study carried out to assess the effects of methanol and aqueous extracts from this plant (500–3000 mg/kg), in Wistar rats with duodenal ulceration, concluded that both extracts produced significant activity in cysteamine-induced duodenal ulceration [ 93 ].…”

Section: Plant Products and Phytochemicals As Antiulcerogenic And mentioning

confidence: 99%

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

et al. 2018

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In this narrative review, we have comprehensively reviewed the plant sources used as antiulcer agents. From traditional uses as herbal remedies, we have moved on to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential. A particular emphasis was also paid to Helicobacter pylori activity, with emphasis on involved mechanisms of action. Lastly, the issue of safety profile of these plant products has also been addressed.

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Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats

Abstract: The plant A. mexicana Linn. Increased healing of gastric ulceration and prevented the development of experimentally induced duodenal ulceration in rats.

Cited by 14 publications

References 5 publications

In vivoameliorative effects of methanol leaf extract ofLawsonia inermisLinn on experimentalTrypanosoma congolenseinfection in Wistar rats

In vivoameliorative effects of methanol leaf extract ofLawsonia inermisLinn on experimentalTrypanosoma congolenseinfection in Wistar rats

Antifungal and Anticancer Potential of Argemone mexicana L.

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

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