Pharmacological enhancement of extinction learning.

Buissonnière-Ariza, Valérie La; Schneider, Sophie C.; Storch, Eric A.

doi:10.1037/0000150-019

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…There is great interest in finding ways to alter extinction learning processes to oppose these traumatic memories ( Kida, 2019 ). Pre-clinical studies have suggested timed brain stimulation ( Milad and Quirk, 2002 ; Vidal-Gonzalez et al, 2006 ; Bukalo et al, 2015 ; Likhtik and Paz, 2015 ), glutamatergic agonists ( Norberg et al, 2008 ; La Buissonnière-Ariza et al, 2020 ), and timed increases in adrenal hormones ( de Kloet et al, 2005 , 2006 ; McEwen, 2005 ; Klaassens et al, 2012 ; Iob et al, 2020 ) as potential strategies for augmenting extinction. Invasive brain stimulation presents a challenge to routine clinical practice, and pharmacologic strategies have shown limited effectiveness in formal trials ( Storch et al, 2007 ; Litz et al, 2012 ; Ressler, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation

et al. 2022

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Exposure to stressful or traumatic stimuli may alter hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) reactivity. This altered reactivity may be a component or cause of mental illnesses. Dissecting these mechanisms requires tools to reliably probe HPA and SAM function, particularly the adrenal component, with temporal precision. We previously demonstrated magnetic nanoparticle (MNP) technology to remotely trigger adrenal hormone release by activating thermally sensitive ion channels. Here, we applied adrenal magnetothermal stimulation to probe stress-induced HPA axis and SAM changes. MNP and control nanoparticles were injected into the adrenal glands of outbred rats subjected to a tone-shock conditioning/extinction/recall paradigm. We measured MNP-triggered adrenal release before and after conditioning through physiologic (heart rate) and serum (epinephrine, corticosterone) markers. Aversive conditioning altered adrenal function, reducing corticosterone and blunting heart rate increases post-conditioning. MNP-based organ stimulation provides a novel approach to probing the function of SAM, HPA, and other neuro-endocrine axes and could help elucidate changes across stress and disease models.

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Section: Introductionmentioning

confidence: 99%

Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation

et al. 2022

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“…There is great interest in finding ways to alter or augment extinction learning processes that could oppose these traumatic memories (13). Pre-clinical studies have suggested timed brain stimulation (14–17), glutamatergic agonists (18,19), and timed increases in adrenal hormones (1–5) as potential strategies for augmenting extinction. Invasive brain stimulation presents a challenge to routine clinical practice, and pharmacologic strategies have shown limited effectiveness in formal trials (20–22).…”

Section: Introductionmentioning

confidence: 99%

Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs

Maeng

Rosenfeld

Simandl

et al. 2021

Preprint

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Exposure to stress alters hypothalamic-pituitary-adrenal (HPA) axis reactivity; however, it is unclear exactly how or where within the HPA pathway these changes occur. Dissecting these mechanisms requires tools to reliably probe HPA function, particularly the adrenal component, with temporal precision. We previously demonstrated magnetic nanoparticle (MNP) technology to remotely trigger adrenal hormone release by activating thermally sensitive ion channels. Here, we applied adrenal magnetothermal stimulation to probe stress-induced HPA axis changes. MNP and control nanoparticles were injected into the adrenal glands of outbred rats subjected to a tone-shock conditioning/extinction/recall paradigm. We measured MNP-triggered adrenal release before and after conditioning through physiologic (heart rate) and serum (epinephrine, corticosterone) markers. Aversive conditioning altered adrenal function, reducing corticosterone and blunting heart rate increases post-conditioning. MNP-based organ stimulation provides a novel approach to probing the function of HPA and other neuro-endocrine axes and could help elucidate changes across stress and disease models.

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Pharmakotherapie von Angsterkrankungen – leitliniengerechte Therapie und Neuentwicklungen

2021

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Pharmacological enhancement of extinction learning.

Abstract: Cognitive behavior therapy (CBT) is the gold-standard treatment for anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (

Cited by 3 publications

References 23 publications

Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation

Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation

Probing Neuro-Endocrine Interactions Through Wireless Magnetothermal Stimulation of Peripheral Organs

Pharmakotherapie von Angsterkrankungen – leitliniengerechte Therapie und Neuentwicklungen

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