Pharmacological evaluation for improvement of Kanazawa Sutra, medicinal thread for anal fistula

Yokogawa, Takami; Sasaki, Yohei; Ando, Hirokazu; Yamamoto, Katsuya; Mikage, Masayuki

doi:10.1007/s11418-016-1059-0

Cited by 5 publications

(5 citation statements)

References 6 publications

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“…Yokogawa et al 18 compared different herbal medicines in the treatment of anal fistula, and found that Capsicum Annuum tincture was superior to Ficus carica latex, Aquirantos fauriei Kshara and long Turmeric rhizome, for promoting greater inhibition in nitric oxide production.…”

Section: Discussionmentioning

confidence: 99%

Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract

Comparin

Santos

Dourado

et al. 2018

Journal of Coloproctology

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Rationale There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C ( p  = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C ( p  = 0.015). Conclusion The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton.

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Section: Discussionmentioning

confidence: 99%

Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract

Comparin

Santos

Dourado

et al. 2018

Journal of Coloproctology

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“…However, recent studies have shown promising results of ayurvedic medicine in surgical illnesses such as anal fistula and urinary stones. [ 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

Comparative morbidity profile of patients attending an Ayurveda clinic and a modern medicine clinic of a primary health center in rural Haryana, India

Kant

Lohiya

Ahamed

et al. 2018

J Family Med Prim Care

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Context:There is a paucity of data on the profile of patients accessing traditional systems of medicine. A comparison of profile of patients attending an Ayurveda clinic with that of modern medicine clinic will help in better understanding of utilization of services and preference for system of medicine by the patients seeking health care.Aim:The aim was to study the morbidity profile of patients who attended the Ayurveda clinic of a primary health center (PHC) in rural Haryana over 1 year and compared it with that of the modern medicine clinic attendees at the same facility.Materials and Methods:The study site was PHC, Dayalpur in block Ballabgarh, district Faridabad, Haryana, India. All new patients who attended the Ayurveda clinic of PHC Dayalpur in the year 2012 were included in the study. New attendees of modern medicine clinic of the same PHC in the year 2012 were used for comparison of profile of patients.Results:In year 2012, of the total new patients registered at PHC, 26% attended Ayurveda clinic. The male-to-female ratio (0.8:1) was similar in both clinics. The representation of children up to 5 years and elderly was significantly higher (12.0% vs. 6.7% and 19.5% vs. 11.0%) in modern medicine clinic as compared to Ayurveda clinic. The most common morbidities seen in Ayurveda clinic were twak vikar or skin disease (12.3%), sandhivata or osteoarthritis (10.3%), and kasa or cough (8.5%). Three most common morbidities in modern medicine clinic were acute respiratory infection (35.7%), hypertension (10.6%), and acute febrile illness (9.2%).Conclusions:The study provided evidence that Ayurveda was popular among rural population in North India. Therefore, the Government of India's initiative of setting up Ayurveda clinic in PHCs is well founded.

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“…Japanese KS, Kanazawa Sutra I, is composed of Achyranthes fauriei ash, Ficus carica latex, Capsicum annuum tincture, and Curcuma longa rhizome. Her team evaluated the efficacy of the Japanese KS in vitro and identified its greater potency [3]. However, a rapid improvement was not achieved via a clinical study (unpublished), and a more detailed investigation of the mechanism of action of KS in vivo may lead to the appropriate in vitro evaluation of its efficacy and the development of new drugs.…”

Section: Mechanism Of Action Of the Ayurveda Drug‐eluting String Ksha...mentioning

confidence: 99%

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Yoshino

Yokogawa

Nakamichi

et al. 2023

Traditional & Kampo Medicine

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Four young researchers presented their studies in the field of traditional Japanese herbal medicine (Wakan‐yaku) at the third annual young researcher forum entitled “Respecting and Breaking Traditions,” held 1 week before the 2022 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Dr. Yokogawa presented her research focusing on the mechanism of the Ayurveda drug‐eluting string, Kshara Sutra, in treating anal fistulas, reporting on its effects on the anal tissue in an anal fistula rat model and its antibacterial activity against Escherichia coli and Staphylococcus aureus, the causative organisms of anal fistulas. Mr. Nakamichi presented his research focusing on the relationship between the efficacy of Kampo medicines with anti‐obesity effects and intestinal microbiota composition. His results partially revealed that bofutsushosan and boiogito affect lipid metabolism in mice and correlate with the intestinal microbiota composition. Dr. Manse reported the anti‐inflammatory activity of diterpenoid components in Enmei‐so (Isodonis Herba), revealing its novel inhibitory activity on nitric oxide released from activated macrophages and on inflammatory cytokines, and identified active components contributing to the inhibition and the mechanism of action. Mr. Yoshikawa reported the anticancer activity of small molecular compounds isolated from the medicinal plants, Valeriana fauriei and Hypericum erectum. His results suggest that five compounds may increase the sensitivity of human cervical carcinoma cells to adriamycin via HSP105 expression suppression. The event was conducted online, and included 78 participants. We intend to hold and improve this forum in 2023 and the future.

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Pharmacological evaluation for improvement of Kanazawa Sutra, medicinal thread for anal fistula

Cited by 5 publications

References 6 publications

Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract

Treatment of rats anal fistula with glycerin Aloe barbadensis Miller extract

Comparative morbidity profile of patients attending an Ayurveda clinic and a modern medicine clinic of a primary health center in rural Haryana, India

Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

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