Pharmacological evaluation of anti -inflammatory activity of Pancha Pashana Chendhuram against carrageenan induced paw edema in Rats

Abstract

The present study investigates the anti-inflammatory activity in ethanolic extract of Pancha Pashana Chendhuram (PPCM) using carrageenan induced paw edema in albino rats. The anti-inflammatory was done by carrageenan induced hind paw edema method using plethysmometer. Indomethacin used as a standard drug. For this activity test groups received Control, Induced 1% Carrageenan (0.1 ml), Standard Indomethacin (40mg/kg) and the PPCM in 10mg/kg and 20mg/kg. The anti-inflammatory activity is more effective in Group V Carrageenan induction with oral administration of PPCM 20mg/kg (40.08%) compared to Group IV Carrageenan induction with oral administration of PPCM 10mg/kg (23.49%). The standard drug indomethacin showed 44.50% inhibition of paw edema. The results suggested that the PPCM has exhibited an effective anti-inflammatory activity mediated via either by inhibition of cyclooxygenase cascade and by blocking the release of vasoactive substances like histamine, serotonin and kinins.