Pharmacological Evaluation of Antipyretic, Analgesic and Anti-inflammatory Activities of Ethanolic Extract of Cassia fistula

Abstract

Background: The antipyretic, analgesic and anti-inflammatory activities of two concentrations (100 and 200 mg/kg) of ethanolic extract of leaf, bark, flower and fruit pulp of C. fistula were determined in male wistar albino rats. Methods: Antipyretic activity was assessed by E. coli endotoxin induced pyrexia. Analgesic activity was assessed by hot plate, tail immersion and acetic acid induced writhing test. Anti-inflammatory activity was evaluated by carrageenan-induced rat paw edema assay. Result: Significant (p less than 0.05) antipyretic activity was exhibited from 2h onwards by bark extract @ 200 mg/kg and from 3h onwards by bark extract @100 mg/kg and leaves extract @ 200mg/kg as compared to control group. Significant (p less than 0.05) analgesic activity was shown by extract of bark @ 200 mg/kg as it is evident by increase in reflex time in hot plate (90,120,180 min), tail immersion test (120,180 min) and inhibition of writhing (32.12%). Significant (p less than 0.05) anti-inflammatory activity was exhibited from 3h post administration by bark @ 200 and leaves @ 100 and 200 mg/kg.

Fig tress (Ficus spp.): Species diversity, medicinal usage and conservation at the Bangladesh Agricultural University Campus

“…For example, F. racemosa has been found to possess potential benefits in the treatment of skin cancer and wound healing (Lalla, 2005, Singh et al,2019. The fruit extracts of F. religiosa, F. benjamina and F. benghalensis have been found to have noteworthy antimicrobial and antibacterial properties as reported by Mousa et al (1994), Sharma et al (2016) and Singh et al (2020a, b). Several species of Ficus are also employed in the treatment of cholera, diarrhoea, dysentery, mumps, vomiting and other related ailments.…”

“…Use : Ficus fistulosa is a traditional medicine used in the remedies of diarrhoea, diabetics and malaria (Sharma et al, 2016). Sometimes they are also cultivated as ornamental plants.…”

“…Ficus is also considered one of the most diversified genera concerning its habits (deciduous and evergreen trees, shrubs, herbs, climbers and creepers) and life forms (free-standing trees, epiphytes, semi-epiphytes in the crevices, rheophytes and lithophytes) (Chaudhary et al, 2012); it grows everywhere in Bangladesh and some of them produce edible fruits (Khatun et al, 2016). Ficus species are used for medicinal properties in Ayurvedic, modern medicine and pharmaceutical applications (Adebayo et al, 2009;Abdulla et al, 2010, Sharma et al, 2016. For example, F. racemosa has been found to possess potential benefits in the treatment of skin cancer and wound healing (Lalla, 2005, Singh et al,2019.…”

“…Ficus is the most conspicuous and problematic genus because its microscopic flowers are located inside the closed fleshy receptacle (i.e., Syconium) (Sharma et al, 2016). Therefore, vegetative morphology plays an important role in the identification of different species (Corner, 1965).…”

Leaf Powder of Eupatorium odoratum Enhances Non-specific Immune Response and Resistance to Aeromonas hydrophila Infection in Cyprinus carpio (Linn. 1758)

“…alkaloids, flavonoids, steroids, phenols, terpenoids, resins, saponins etc. are having unique properties to enhance the immune system of finfish and shellfish by enhancing the phagocytic, lysozyme and other complementary activities along with antipyretic, analgesic, anti-inflammatory, antistress property, appetite stimulator, growth promoter as well as antimicrobial activity (Citarasu, 2010;Sharma et al 2022). A large number of plants have been used in traditional medicine for the treatment and control of many diseases (Duke, 1987).…”