Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage

Jain, Pushpendra Kumar; Kharya, Murli Dhar; Gajbhiye, Asmita

doi:10.3109/03639045.2012.738685

Cited by 26 publications

(18 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results were achieved by other two studies, in which MF was submitted to complexation with different types of phospholipids, that is, egg phospholipid Lipoid E 80, with a percentage of phosphatidylcholine about 80%, and soya phospholipid Lipoid S 100, with a percentage of phosphatidylcholine about 100% . The bioavailability was measured through improved pharmacokinetic parameters and antioxidant and hepatoprotective activities in experimental animals.…”

Section: Chemistry and Bioavailabilitysupporting

confidence: 84%

“…In recent years, a growing number of studies has focused on the improvement of oral bioavailability through the increase of solubility and more recently through the increase of both solubility and membrane permeability . One of the earliest studies aimed to increase the absorption of MF in the gastrointestinal tract through the membrane permeability improvement, was published by Wang et al .…”

Section: Chemistry and Bioavailabilitymentioning

confidence: 99%

See 1 more Smart Citation

The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects

2016

View full text Add to dashboard Cite

Mangiferin (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside) is a natural bioactive xanthonoid that can be found in many plant species, among which the mango tree (Mangifera indica L), a plant widely used in the traditional medicinal, is one of its primary sources. The use of mangiferin for cancer treatment has attracted the attention of research groups around the World. Single administration of mangiferin or in combination with known anticancer chemicals has shown the potential benefits of this molecule in lung, brain, breast, cervix, and prostate cancers, and leukemia. Mangiferin mechanisms of action against cancer cells through in vitro, ex vivo, or in vivo models are discussed besides its antioxidant and anti-inflammatory properties. Nevertheless, pharmaceutical development and, therefore, clinical trials on cancer targets are still lacking. © 2016 BioFactors, 42(5):475-491, 2016.

show abstract

Section: Chemistry and Bioavailabilitysupporting

confidence: 84%

Section: Chemistry and Bioavailabilitymentioning

confidence: 99%

The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects

2016

View full text Add to dashboard Cite

show abstract

“…Mechanistically, it also inhibited Pb(II)-induced activation of nuclear translocation of NF-κB, mitogen-activated protein kinases (MPAKs) (phosphor-ERK 1/2, phosphor-JNK phosphor-p38), and apoptotic cell death. Similarly, mangiferin considerably lowered the levels of total bilirubin, ALP, serum-glutamate pyruvate-transminase (SGPT), and serum-glutamate oxaloacetate-transminase (SGOT) [88]. …”

Section: Oxidative Stressmentioning

confidence: 99%

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

et al. 2017

View full text Add to dashboard Cite

The current review article is an attempt to explain the therapeutic potential of mangiferin, a bioactive compound of the mango, against lifestyle-related disorders. Mangiferin (2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) can be isolated from higher plants as well as the mango fruit and their byproducts (i.e. peel, seed, and kernel). It possesses several health endorsing properties such as antioxidant, antimicrobial, antidiabetic, antiallergic, anticancer, hypocholesterolemic, and immunomodulatory. It suppresses the activation of peroxisome proliferator activated receptor isoforms by changing the transcription process. Mangiferin protects against different human cancers, including lung, colon, breast, and neuronal cancers, through the suppression of tumor necrosis factor α expression, inducible nitric oxide synthase potential, and proliferation and induction of apoptosis. It also protects against neural and breast cancers by suppressing the expression of matrix metalloproteinase (MMP)-9 and MMP-7 and inhibiting enzymatic activity, metastatic potential, and activation of the β-catenin pathway. It has the capacity to block lipid peroxidation, in order to provide a shielding effect against physiological threats. Additionally, mangiferin enhances the capacity of the monocyte-macrophage system and possesses antibacterial activity against gram-positive and gram-negative bacteria. This review summarizes the literature pertaining to mangiferin and its associated health claims.

show abstract

“…MF herbosomes also showed significantly decreased level of malonyl dehydrogenase along with increased levels of reduced glutathione, superoxide dismutase (SOD) and catalase as compared to plain MF which was also comparable to the standard drug, Silymarin (SL). 20 The traditional uses of Andrographolide (AN) obtained from Andrographis paniculata Linn include treatment of fever, inflammation, common cold, tonsilitis, pharyngitis, laryngitis, pneumonia, tuberculosis, pyelonephritis and hepatic impairment etc. The equimolar dose of drug shows lesser absorption and elevated levels of SGOT and SGPT in serum as compared to its phytosome dose indicating its hepatoprotective nature.…”

Section: Hepato-protectivementioning

confidence: 99%

A Review on Therapeutic Applications of Phytosomes

Chivte¹,

Pardhi²,

Joshi³

et al. 2017

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Ethnobotanical plants have been used in the treatment of various diseases since antiquity. The phytoconstituents have pharmacological activities such as anti-tumor, anti-inflammatory, antinociceptive, anti-obesity, thermoregulatory effects, cardioprotective, anti-asthmatic, anti-diabetic, anti-oxidant, hepatoprotective and potent CNS activities. Various drug delivery systems like liposomes, niosomes, transferosomes, ethosomes, phytosomes, colloidosomes etc. are developed in order to carry the drug to the site of action without its metabolism. The major concern with respect to phytoconstituents having different chemical nature is its bioavailability and effective dosage concentration which could be overcome by means of phytosome technology. Chemically, phytosomes are vesicles of phospholipids bonded with a hydrogen bond to phytochemical/s. The current review highlights the major therapeutic applications of phytosomes till date. The review discusses about a latest and novel drug delivery system viz. "Phytosome technology" whereby major emphasis has been provided on the different therapeutic applications of phytosomes and its crucial role in managing the conventional complications that are encountered for the delivery of phytoconstituents. Applications of phytosomes such as enhancing bioavailability, anti-cancer and anti-oxidant agent, transdermal delivery, wound healing capacity etc. have been discussed. The comparison between the therapeutic activities of free drug and its phytosomes indicates that the complex provides various advantages over the conventional treatments.

show abstract

Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage

Abstract: The above mentioned results showed that hepatoprotective and antioxidant potency of MF enhanced due to the preparation of its herbosomes.

Cited by 26 publications

References 16 publications

The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects

The potential role of mangiferin in cancer treatment through its immunomodulatory, anti‐angiogenic, apoptopic, and gene regulatory effects

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

A Review on Therapeutic Applications of Phytosomes

Contact Info

Product

Resources

About