Pharmacological evaluation of the extracts of<i>Sphaeranthus indicus</i>flowers on anxiolytic activity in mice

Ambavade, Shirishkumar D.; Mhetre, NA; Tate, VD; Bodhankar, Subhash L.

doi:10.4103/0253-7613.27021

Cited by 39 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The light and dark box test was completed as described protocol (Ambavade et al, 2006). The box having a size of 30 × 20 × 14 cm with a fixed partition in` the middle.…”

Section: Light and Dark Box (Ldb) Testmentioning

confidence: 99%

Pharmacological and ADMET-based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro, in vivo and in silico models

Hossain

Rahman

Rafi

et al. 2020

Not Bot Horti Agrobo

View full text Add to dashboard Cite

This research investigated pharmacological properties mainly the anti-inflammatory, anthelmintic, thrombolytic and anxiolytic potential of methanol extract of Syzygium samarangense (MESS) var. parviflorum. Anti-inflammatory action by bovine serum albumin, egg albumin denaturation and membrane stabilization, anthelmintic by live parasites, thrombolytic by clot lysis and anxiolytic by elevated plus maze (EPM) and light and dark box (LDB) tests were measured. The four targeted pharmacological properties were further justified using the most prevalent compounds, isolated from this plant, to be undergone for their pharmacokinetic property’s analyses, sitemap analyses and lignad-receptor interactions by computational models through SwissADME and Schrödinger, 2018 softwares against PDB 6COX, 6D6T, 1JFF receptors. MESS was found to display statistically significant (P < 0.05) inhibition of Bovine Serum albumin and Egg albumin denaturation compared to reference drug diclofenac sodium. Remarkable vermicidal effect on the paralysis and death of anthelmintic parasites was observed at MESS concentration 200 mg/dL. A nondescript clot lysis of MESS compared to streptokinase was evident in in vitro thrombolytic assay. MESS increased the number of times the animal crossed from one compartment to the other and the time spent in the brightly-lit chamber of the LDB. Three-methylchalcone derivatives out of seven MESS compounds were undertaken, based on cut off value and sitemap prediction score, for further ligand-receptor binding efficiency. All these three compounds showed promising docking score, glide emodel and glide energy against PDB 6COX, 6D6T and 1DDJ, plasmin proteins demonstrating the prospects of MESS to be materialized for anti-inflammatory, anthelmintic, and thrombolytic therapeutics with further clarification.

show abstract

“…The light and dark box test was completed as described protocol (Ambavade et al, 2006). The box having a size of 30 × 20 × 14 cm with a fixed partition in` the middle.…”

Section: Light and Dark Box (Ldb) Testmentioning

confidence: 99%

Pharmacological and ADMET-based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro, in vivo and in silico models

Hossain

Rahman

Rafi

et al. 2020

Not Bot Horti Agrobo

View full text Add to dashboard Cite

show abstract

“…Chronic exposure to elevated levels of glucose and fasting blood glucose causes β-cell dysfunction and may induce β-cell apoptosis in type 2 diabetes. The deficit of β-cell mass seems to be caused mainly by increased β-cell apoptosis (Ambavade et al 2006). Spinacia oleracea is an edible flowering plant in the family of Chenopodiaceae, common name is spinach or in Hindi known as Palak.…”

Section: Introductionmentioning

confidence: 99%

Structure Elucidation, Phytochemical Investigation and Pharmacological Screening of Spinacia Oleracea for Anti-Diabetic Activity

Rajawat¹,

Tiwari²,

Sharma³

et al. 2023

Preprint

View full text Add to dashboard Cite

The present study was based on structure elucidation, phytochemical investigation, and pharmacological screening of Spinacia oleracea for anti-diabetic activity. The qualitative phytochemical screening of the extracts was analysed for the presence of alkaloids, carbohydrates, glycosides and anthraquinones, flavonoids, tannins and phenolic compounds, proteins and amino acids, saponins, sterols and or triterpenes. In this study, the methanolic extract of S. oleracea had shown the presence of numerous phytoconstituents. The isolation of compounds was performed on the methanolic extract of S. oleracea using column chromatography. In S. oleracea, erythritol was isolated kaempferol was isolated. The compounds were identified based on the spectral studies i.e., Infrared spectroscopy (IR), Nuclear Magnetic Resonance (1H-NMR & 13C-NMR) and Mass Spectra and the structure was elucidated. The diabetic rats exhibited lower activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and reduced glutathione (GSH) content in pancreas and hepatic tissues as compared with normal rats. The activities of SOD, CAT, GPx and GSH were found to be increased in S. oleracea (200mg/kg) treated diabetic rats. The increased level of malondialdehyde, an index of lipid peroxidation in diabetic rats was also found to be reverted to near-normal status in extract-treated groups. S. oleracea (200mg/kg) ameliorated the histopathological changes in the hepatic and pancreas tissues. Glibenclamide was used as a reference and showed similar antidiabetic effect. The structural changes are clearly oxidative in nature and are associated with development of vascular disease in diabetes. In results, it demonstrated statistically significant hypoglycemic and hypocholesteremia-like action when observed and compared with control group. It also exhibited potent anti-oxidant potential. In conclusion, it might be said that Spinacia oleracea is effective in the management of diabetes mellitus having numerous potential bioactive molecules. It could be used in the treatment of Type-II diabetes mellitus and to replenish the electrolytes and minerals in abundance.

show abstract

“…It is a naturally occurring anthelmintic utilized in the Indian medical system 4 . The herb has been used for a variety of ailments, including hemicranias, jaundice, leprosy, diabetes, fever, pectoralgia, cough, gastropathy, hernias, haemorrhoids, helminthiasis, dyspepsia, skin conditions, and nerve tonic 5,6 . This plant has been linked to pharmacological effects like immunomodulatory 7 , antimicrobial 8,9 , antibacterial 10,11 , anxiolytic 6 , and wound healing action 12 .…”

Section: Introductionmentioning

confidence: 99%

“…The herb has been used for a variety of ailments, including hemicranias, jaundice, leprosy, diabetes, fever, pectoralgia, cough, gastropathy, hernias, haemorrhoids, helminthiasis, dyspepsia, skin conditions, and nerve tonic 5,6 . This plant has been linked to pharmacological effects like immunomodulatory 7 , antimicrobial 8,9 , antibacterial 10,11 , anxiolytic 6 , and wound healing action 12 . Eudesmanolides, isoflavonoids, 7-hydroxy eudesmanolides, sterol glycosides, essential oils (cadiene, ocimene, citral, pmethoxycinnamaldehyde, geraniol, eugenol, and geranyl acetate), and eudesmanolides are phytoconstituents identified from this plant [13][14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Qualitative and Quantitative Determination of Secondary Metabolites of Sphaeranthus indicus and Spathodea campanulata Flowers Extracts

Chauhan

Yadav

2023

J. Drug Delivery Ther.

View full text Add to dashboard Cite

Since the dawn of time, humans have used plants as a natural source for healing and remedies. Among these, medicinal herbs have gained popularity due to their widespread use and lack of negative side effects. The globe has seen a rise in plant study in recent years, and a tonne of data has been gathered to demonstrate the enormous potential of the therapeutic plants employed in many traditional systems. In this work, flower extracts of Sphaeranthus indicus and Spathodea campanulata from the Madhya Pradesh region of Bhopal were evaluated for their qualitative and quantitative phytochemical composition. The well-known test procedure described in the literature was used to determine the quantitative analysis of total phenolics and flavonoids as well as the qualitative analysis of various phytochemical constituents. Sphaeranthus indicus and Spathodea campanulata both included alkaloids, carbohydrates, saponins, fixed oils and lipids, flavonoids, and phenolics, according to phytochemical analyses. By using the Folins Ciocalteau reagent method and the aluminium chloride method, respectively, phenolic and flavonoid quantities were analysed quantitatively. The amount of total phenolics in the methanolic extract of the flowers of Sphaeranthus indicus and Spathodea campanulata was 18.23±0.16 and 217.00±0.916mg/gm, respectively. Flavonoids came in second with 164.10±0.52 and 79.33±3.511mg/gm. This research gave information that might be used to standardize and correctly identify this plant material. The wide range of phytochemicals found in the plant thus points to its medicinal potentials, which could be investigated in both traditional medicine and the drug manufacturing business. Keywords: Sphaeranthus indicus, Spathodea campanulata, Qualitative analysis, quantitative analysis, Phytochemical analysis

show abstract

Pharmacological evaluation of the extracts ofSphaeranthus indicusflowers on anxiolytic activity in mice

Cited by 39 publications

References 14 publications

Pharmacological and ADMET-based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro, in vivo and in silico models

Pharmacological and ADMET-based pharmacokinetic properties of Syzygium samarangense var. parviflorum leaf extract in in vitro, in vivo and in silico models

Structure Elucidation, Phytochemical Investigation and Pharmacological Screening of Spinacia Oleracea for Anti-Diabetic Activity

Qualitative and Quantitative Determination of Secondary Metabolites of Sphaeranthus indicus and Spathodea campanulata Flowers Extracts

Contact Info

Product

Resources

About