Pharmacological evidence for the use of Cissus assamica as a medicinal plant in the management of pain and pyrexia

Abstract

The existing therapeutic agents for the management of pain and pyrexia are not very efficient and accompanied by numerous side effects. Thus, new effective agents are the most needed. The present study investigates bioactivities and phytochemical screening of different parts of Cissus assamica (Vitaceae), a Bangladeshi tribal medicinal plant. Three plant parts stems, leaves and roots were collected, washed, dried, powdered and then prepared for cold extraction. The methanolic stems and leaves extracts were fractioned with four and two solvents respectively. Different plant extracts were then investigated for in vivo antinociceptive activity and only methanolic leaves extract was investigated for in vivo antipyretic activity. In Swiss-albino mice, 200 and 400 mg/kg body weight doses were used for all extracts. In the peripheral antinociceptive activity, the methanolic stem extract and its dichloromethane, chloroform, pet ether fractions and methanolic roots extract at their both doses showed significant antinociceptive responses when compared to standard diclofenac sodium (60.49% inhibition). In the central antinociceptive activity, the response was found significant for methanolic stem and methanolic roots extract in their both doses compared to standard morphine. In antipyretic activity, methanolic leaves extract significantly reduced pyrexia level at 400 and 200 mg/kg body weight doses after two, three and 4 h of administration when compared to standard. So our findings indicate that this plant possesses noteworthy pharmacological activities which may be a basis for further researches to establish a possible mode of action of its different parts.

Scrutinizing pharmacological efficiency for Acacia auriculiformis by experimental and computational approach

“…This reduction of temperature was observed might be due to the presence of some pharmacologically active constituents in A. auriculiformis, which interfere with the synthesis of prostaglandin. However, phytochemicals, specifically steroids and flavonoids, are known as a good antipyretic agent and in the previous study presence of these phytochemicals has been observed in A. auriculiformis [13,48]. Nevertheless, it must be noted that diverse biochemical reactions take place during the synthesis of prostaglandins.…”

Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd

“…In addition, the products used in traditional medicine are processed in various forms, such as powder, extracts, capsules, and tablets. Phytochemical characterization could therefore be used in the identification and authentication of several medicinal plants [ 20 , 21 , 22 , 23 , 24 , 25 ].…”

Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms

“…Besides, organic acid is also thought to function indirectly to trigger the release of endogenous mediators that activate nociception [49,50]. It is notable that NSAIDs and pain-relieving drugs act by preventing moderate degrees of pain with the formation of antinociceptive signals that block the synthesis of prostaglandins, tumor necrosis factor-α, and bradykinin [51]. During the writhing test, MEAM and the standard drug diclofenac sodium showed a significant (p < 0.001) and dose-dependent number of writhing events as compared with in the control group.…”