Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats

Kotani, Susumu; Yamauchi, Toshihiko; Teramoto, Takashi; Ogura, Hiroo

doi:10.1016/j.neuroscience.2006.06.035

Cited by 165 publications

(121 citation statements)

References 45 publications

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“…In contrast to the effects of these antidepressant drugs, chronic ZSET1446 administration did not affect cell proliferation in sham-operated mice. However, administrations of 4, but not 2 weeks with donepezil, an AChE inhibitor, enhanced neurogenesis in normal rats (Kotani et al, 2006). Thus, further prolonged administration with ZSET1446 may be required to stimulate hippocampal neurogenesis in normal animals.…”

Section: Discussionmentioning

confidence: 97%

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

Shioda

Yamamoto

Han

et al. 2010

J Pharmacol Exp Ther

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In the adult brain, neurogenesis persistently occurs in the subgranular zone of the hippocampal dentate gyrus (DG), and impaired neurogenesis is implicated in depressive behaviors and poor learning memory. Here, we investigated the effects of oral administration of spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101), a novel cognitive enhancer stimulating acetylcholine release, on adult neurogenesis in olfactory bulbectomized (OBX) mice. OBX mice showed significant decreases in the number of newborn cells in the DG by immunohistochemical analysis of 5-bromo-2-deoxyuridine incorporation. Impaired neurogenesis observed in OBX mice was significantly improved by chronic administration with ZSET1446. We confirmed that administration with mecamylamine, a nicotinic acetylcholine receptor antagonist, inhibits ZSET1446-enhanced neurogenesis in the DG. ZSET1446 administration also restored decreased phosphorylation of Akt and extracellular signal-regulated kinase in the DG of OBX mice. Consistent with restored neurogenesis, chronic but not single ZSET1446 administration promoted significant decreases in immobility in tail suspension tests and improved cognitive behaviors in OBX mice. Taken together, chronic ZSET1446 administration antagonized impaired neurogenesis seen in OBX mice, an effect closely associated with improvement of depressive behavior.

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Section: Discussionmentioning

confidence: 97%

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

Shioda

Yamamoto

Han

et al. 2010

J Pharmacol Exp Ther

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“…Manipulations of ACh levels can alter both proliferation and survival (Cooper- Kuhn et al, 2004, Mohapel et al, 2005. However, a recent paper showed that chronic acetylcholinesterase (AChE) antagonist treatment results in increased cell survival in the SGZ without affecting cell proliferation or fate (Kotani et al, 2006). While it is intriguing to consider whether perturbations in cholinergic signaling contribute to the enhanced survival reported here, cholinergic receptor binding as well as AChE activity are both normal in MOR KO mice (Tien et al, 2004).…”

Section: Possible Mechanisms For Mor Regulation Of Neurogenesismentioning

confidence: 89%

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Harburg¹,

Hall²,

Harrist³

et al. 2007

Neuroscience

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Recent evidence suggests that mu opioid receptors (MOR) are key regulators of hippocampal structure and function. For example, exogenous MOR agonists morphine and heroin negatively impact hippocampal function and decrease adult hippocampal neurogenesis. Here we explored the role of MOR in the birth and survival of hippocampal progenitor cells by examining adult neurogenesis in mice that lack MOR. Adult male mice lacking exon 1 of MOR were injected with the S phase marker bromodeoxyuridine (BrdU) and sacrificed either two hours or four weeks later to evaluate proliferating and surviving BrdU-immunoreactive (IR) cells, respectively, in the adult hippocampal granule cell layer. WT, heterozygote, and homozygote mice did not differ in the number of BrdU-IR cells at a proliferation time point. However, four weeks after BrdU injection, heterozygote and homozygote mice had 57% and 54% more surviving BrdU-IR cells in the hippocampal granule cell layer as compared to WT mice. A decrease in apoptosis in the heterozygote and homozygote mice did not account for the difference in number of surviving BrdU-IR cells since there were no alterations in number of pyknotic, TUNEL-positive, or activated caspase 3-IR cells compared to WT. In concordance with the increased numbers of granule cells maturing into neurons, heterozygote and homozygote mice had larger hippocampal granule cell layers and increased numbers of granule cells. These findings indicate that MOR may play a role in regulating progenitor cell survival and more generally encourage further exploration of how MOR activation can influence hippocampal structure and function.

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“…Acetylcholine is one of the most important neurotransmitters involved in learning and memory (Kotani et al, 2006). Activation of the central cholinergic function has been considered to enhance hippocampal neurogenesis, thereby contributing to the improvement in cognitive function.…”

Section: Donepezil and Insulin-like Growth Factor-imentioning

confidence: 99%

“…Activation of the central cholinergic system has been shown to induce hippocampal neurogenesis, thereby contributing to improvement of cognitive function (Kotani et al, 2006). In this context, the selective acetylcholinesterase inhibitor donepezil has been reported to improve the cognitive impairment in Alzheimer's disease (Winblad et al, 2006).…”

mentioning

confidence: 99%

Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus

Narimatsu

Harada²,

Kurihara

et al. 2009

J Pharmacol Exp Ther

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Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats

Cited by 165 publications

References 45 publications

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus

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