Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells.

Boelcke, Willian Peter; Teixeira, Isadora Ferrari; Aquino, Iara Gonçalves; Mazzaro, Amanda; Zelaya, Florence Juana María Cuadra; Souza, Ana Paula de; Salo, Tuula; Coletta, Ricardo D.; Graner, Edgard; Bastos, Débora Campanella

doi:10.1016/j.archoralbio.2021.105343

Cited by 5 publications

(3 citation statements)

References 58 publications

(78 reference statements)

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“…Additionally, orlistat or FASN siRNA treatment increased cell cytotoxicity and cell sensitivity to radiotherapy in the radioresistant HNSCC cell line rSCC-61 (83). Orlistat also increased the chemosensitivity of OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1 (84). Moreover, other FASN inhibitors, such as C75 and Tvb-3166, have been shown potential as antineoplastic agents (84,85).…”

Section: Acetyl-coa Carboxylasesmentioning

confidence: 99%

“…Orlistat also increased the chemosensitivity of OSCC cells to cisplatin and paclitaxel by downregulating cyclin B1 (84). Moreover, other FASN inhibitors, such as C75 and Tvb-3166, have been shown potential as antineoplastic agents (84,85). Further research is needed to explore the therapeutic implications of targeting FASN in HNC treatment.…”

Section: Acetyl-coa Carboxylasesmentioning

confidence: 99%

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Lipid metabolism reprogramming in head and neck cancer

Liang,

Li,

et al. 2023

Front. Oncol.

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Lipid metabolism reprogramming is one of the most prominent metabolic anomalies in cancer, wherein cancer cells undergo dysregulation of lipid metabolism to acquire adequate energy, cell membrane building blocks, as well as signaling molecules essential for cell proliferation, survival, invasion, and metastasis. These adaptations enable cancer cells to effectively respond to challenges posed by the tumor microenvironment, leading to cancer therapy resistance and poor cancer prognosis. Head and neck cancer, ranking as the seventh most prevalent cancer, exhibits numerous abnormalities in lipid metabolism. Nevertheless, the precise role of lipid metabolic rewiring in head and neck cancer remains unclear. In line with the LIPID MAPS Lipid Classification System and cancer risk factors, the present review delves into the dysregulated molecules and pathways participating in the process of lipid uptake, biosynthesis, transportation, and catabolism. We also present an overview of the latest advancements in understanding alterations in lipid metabolism and how they intersect with the carcinogenesis, development, treatment, and prognosis of head and neck cancer. By shedding light on the significance of metabolic therapy, we aspire to improve the overall prognosis and treatment outcomes of head and neck cancer patients.

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Section: Acetyl-coa Carboxylasesmentioning

confidence: 99%

Section: Acetyl-coa Carboxylasesmentioning

confidence: 99%

Lipid metabolism reprogramming in head and neck cancer

Liang,

Li,

et al. 2023

Front. Oncol.

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show abstract

“…Epstein-Barr virus could promote FASN expression in NPC cells (35, 56) and FASN transcription was increased in cisplatin-resistant SCCs and played a role in cisplatin resistance (57). Furthermore, FASN siRNA inhibited the growth of in vivo oral SCC and lymph node metastasis (58), and FASN inhibitors increased the sensitivity to radiotherapy (59). The aforementioned results suggest that inhibition of FA synthesis would be a novel and exciting treatment for HNSCCs.…”

Section: Fa De Novo Synthesismentioning

confidence: 99%

Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

et al. 2022

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Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the “vital” cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.

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Isolation and phenotypic characterization of cancer stem cells from metastatic oral cancer cells

Aquino,

Cuadra‐Zelaya,

Bizeli

et al. 2024

Oral Diseases

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ObjectivesTo isolate cancer stem cells (CSC) from a metastatic oral squamous cell carcinoma (OSCC) cell line and investigate their in vitro and in vivo phenotypic characteristics.Materials and MethodsSubpopulations with individual staining intensities for CD44 and CD326 were isolated from the OSCC cell line LN‐1A by FACS: CD44Low/CD326− (CSC‐M1), CD44Low/CD326High (CSC‐E), and CD44High/CD326− (CSC‐M2). Proliferation, clonogenic potential, adhesion, migration, epithelial‐mesenchymal transition markers, and sensitivity to cisplatin and TVB‐3166 were analyzed in vitro. Tumor formation and metastasis were assessed by subcutaneous and orthotopic inoculations into BALB/c mice.ResultsE‐cadherin levels were higher in CSC‐E cells while vimentin and Slug more produced by CSC‐M2 cells. CSC‐M1 and CSC‐M2 subpopulations showed higher proliferation, produced more colonies, and have stronger adhesion to the extracellular matrix. All cell lines established tumors; however, CSC‐E and CSC‐M2 formed larger masses and produced more metastases.ConclusionThe CSC subpopulations here described show increased cancer capabilities in vitro, tumorigenic and metastatic potential in vivo, and may be exploited in the search for novel therapeutic targets for OSCC.

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Pharmacological fatty acid synthase inhibitors differently affect the malignant phenotype of oral cancer cells.

Cited by 5 publications

References 58 publications

Lipid metabolism reprogramming in head and neck cancer

Lipid metabolism reprogramming in head and neck cancer

Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

Isolation and phenotypic characterization of cancer stem cells from metastatic oral cancer cells

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