Pharmacological interventions for osteoporosis in people with chronic kidney disease stages 3-5D

Hara, Takashi; Hijikata, Yasukazu; Matsubara, Yukiko; Watanabe, Norio

doi:10.1002/14651858.cd013424

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…With the aging of the population, the incidence of osteoporotic fractures might be increased by approximately 25% in the next 10 years. Loss of bone mineral density (BMD) is the major diagnostic metrics of OP due to an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation in these patients ( 9 – 11 ). However, this diagnostic method is usually performed after the onset of the symptoms of osteoporotic patients, which might delay all the efforts at prevention and treatment.…”

Section: Introductionmentioning

confidence: 99%

Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Hao

Guan

et al. 2022

Front. Endocrinol.

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Bone development have been shown to play an important role in regulating hematopoiesis as one major component of bone marrow microenvironment. Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis, however, little is known about the alterations in the hematopoietic lineages in pathologic conditions. Using various osteoporotic mouse models, we show here that bone microarchitecture abnormalities alter parameters of peripheral blood cells. The level of white blood cells is dynamics and negatively correlated with bone mineral density during the progression of osteoporosis. Furthermore, our clinical data confirm that osteoporosis is associated with abnormal circulating blood cell counts. These results demonstrated a causal link that osteoporosis is accompanied by the altered circulating blood cells, supporting the idea of a close interplay between hematopoiesis and bone homeostasis. Our study would propose that routine complete blood count might be applied as a potential diagnostic and putative marker for osteoporosis.

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Section: Introductionmentioning

confidence: 99%