Pharmacological interventions for spasticity following spinal cord injury

Taricco, Mariangela; Adone, R; Pagliacci, Christina; Telaro, Elena

doi:10.1002/14651858.cd001131

Cited by 104 publications

(98 citation statements)

References 42 publications

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“…28 It can be treated with oral medication (such as baclofen, tizanidine, clonidine), injection of botulinum toxin for localised spasms or intrathecal administration of baclofen or clonidine. 29 However, there is still insufficient evidence to support treatment with oral spasmolytics. Localised spasticity may be treated with botulinum toxin which is effective for 3 months after injection, reducing spasms and improving function.…”

Section: Bowel Incontinencementioning

confidence: 99%

“…Localised spasticity may be treated with botulinum toxin which is effective for 3 months after injection, reducing spasms and improving function. Treatment of nonlocalised spasticity by use of intrathecal baclofen has proven effective in relieving symptoms, 29 although it is clear that patients frequently suffer complications. 30 Intrathecal baclofen may also improve neurogenic bowel 31 and increase functional bladder capacity and compliance.…”

Section: Bowel Incontinencementioning

confidence: 99%

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Sexual rehabilitation of women with a spinal cord injury

Forsythe¹,

Horsewell²

2005

Spinal Cord

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Results: The literature focuses on the effect of neurological change on women's ability to achieve sexual arousal and orgasm. Urinary and bowel incontinence, spasticity, vaginal lubrication and autonomic dysreflexia are the physical consequences of SCI that appear to have most impact on sexual activity. More recent studies have acknowledged that psychosocial factors such as age and partnership status may also affect the successful sexual rehabilitation. Discussions with women with SCI in Denmark and Sweden on their reactions to information and counselling offered during rehabilitation revealed an overwhelming need for the exchange of information and experience with other women with SCI, and a desire for opportunities for counselling after initial rehabilitation. Conclusion: Successful sexual rehabilitation of women with SCI demands a holistic approach that considers individual neurological, physical and psychosocial circumstances. Peer-counselling could make a significant contribution to the sexual rehabilitation of women with SCI.

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Section: Bowel Incontinencementioning

confidence: 99%

Section: Bowel Incontinencementioning

confidence: 99%

Sexual rehabilitation of women with a spinal cord injury

Forsythe¹,

Horsewell²

2005

Spinal Cord

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“…Baclofen is rapidly absorbed after oral administration and has a therapeutic half-life of about 3 to 4 hours. However, the use of this pharmacological agent can be limited by its adverse effects, which include sedation, fatigue, drowsiness, ataxia, and mental confusion [15][16][17][18][19], which can actually reduce the effectiveness of rehabilitation programs [11].…”

Section: Baclofenmentioning

confidence: 99%

Latest Approaches for the Treatment of Spasticity and Autonomic Dysreflexia in Chronic Spinal Cord Injury

Rabchevsky

Kitzman

2011

Neurotherapeutics

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Summary: Two of the most prevalent secondary complications following spinal cord injury (SCI), besides loss of function and/ or sensation below the level of injury, are uncontrolled muscle spasticity and hypertensive autonomic dysreflexia. Despite the desires of the SCI community, there have been few advances in the treatment and/or management of these fundamental impediments to the quality of life associated with chronic SCI. Therefore, the purpose of this review is to focus on current drug treatment strategies that alleviate symptoms of spasticity and autonomic dysfunction. Subsequently, looking ahead, we discuss whether individuals suffering from autonomic dysreflexia and/or muscle spasms can take certain compounds that specifically and rapidly block the neurotransmission of pain into the injured spinal cord to get rapid relief for both aberrant reflexes for which painful stimuli below the level of SCI are common precipitants.

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“…Oxybutynin is used for the treatment of detrusor overactivity 1 and Dantrolene to reduce spasticity. [2][3][4] Oxybutynin has both an antimuscarinic and a direct muscle relaxant effect and, in addition, a local anesthetic activity. 5 It may have anticholinergic side effects, including dry mouth, blurred vision, somnolence, constipation, and delirium.…”

Section: Introductionmentioning

confidence: 99%