Pharmacological investigation of KC-764, a new antiplatelet drug, in experimental animals

KC‐764, a Novel Antiplatelet Drug

“…Antithrombotic, including antiplatelet, drugs may have beneficial effects in the treatment or prevention of unstable angina or acute myocardial infarction (19). A recent publication described the effect of KC-764 on the cyclic reduction of coronary flow (CRCF), possibly caused by alternate platelet adhesion and aggregation, thrombus formation, and dislodgement of thrombi in the severely stenosed and deendothelialized coronary arteries (15). To induce spontaneous CRCF in open-chest dog, we used partial constriction of coronary artery according to the method by Uchida et al of experiments.…”