Pharmacological investigation of leaves of Polypodium decumanum for anti-bacterial activity against gram-positive and gram-negative bacteria

Abstract

Available online on:15.06.2017@http://ijrdpl.com http://dx.doi.org/10.21276/IJRDPL.227 8-0238.2017.6(4). [2685][2686][2687][2688] ABSTRACT:The widespread use of antibiotics has led to an increase in multidrugresistant bacteria, which represent a serious risk of infection, in view of this problem the aim of this research was performed to characterize the antibacterial effect of ethanolic and petroleum ether extract of Polypodium decumanum leaves against three gram-positive bacteria(Staphylococcus aureus, Bacillus subtilius, and Streptococcus pyogenes) and three gram-negative bacteria(Pseudomonas aeruginosa, Escherichia coli, and Pseudomonas alcaligenes) in vitro by disc-diffusion method. In this study, we have taken 3 concentrations of Polypodium decumanumplant extract (ethanolic and petroleum ether) viz. 50 mg/ml, 100 mg/ml, and 200 mg/ml, and observed that the ethanolic extract of Polypodium decumanumof the concentration of 200 mg/ml showed higher antibacterial effect compare to other concentration against all 3 gram-positive bacteria and all 3 gram-negative bacteria, but not higher than standard drug Ampicillin.

Ameliorative effect of Anthocephalus cadamba, Brassica juncea and Pithecellobium dulce against fipronil-induced hemato-biochemical alterations in rats

“…In this study, the co-treatment with Kadamba significantly reduced the levels of ALT, AST, LDH, and Creatinine Kinase compared to the administration of Fipronil alone. The results were in accordance with previous studies [23,[31][32] , where extract of Anthocephalus cadamba significantly reduced the elevated level of these parameters. Similarly, co-treatment with Jungle Jalebi in Fipronil-administered rats led to a reduction in the serum levels of liver biomarker enzymes The findings corroborate to Toudji et al, (2017) [24] , Pradeepa et al, (2013) [25] and Bhoopendra and Nitesh, (2014) [33] where similar decrease in these enzyme activity were observed in the Wistar rats.…”