Pharmacological investigations of the vasodilator nerves supplying the duck's foot

Bell, C.; Rome, Annette

doi:10.1111/j.1476-5381.1984.tb16476.x

Cited by 13 publications

(3 citation statements)

References 21 publications

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“…Although our results indicate that the dilator fibre population is distinct from the mediating eccrine sweat secretion, it could be activated physiologically in parallel with the sudomotor population, and so might participate in the local hyperaemia necessary for effective sweat production. On the other hand, vasodilator nerves are known to supply the digital vasculature in a variety of avian species, where sweat glands are absent (Johansen & Millard, 1974;Bell & Rome, 1984), so similar neural populations might be expected to exist in mammals.…”

Section: Discussionmentioning

confidence: 99%

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Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation.

Bell¹,

Jänig²,

Kümmel³

et al. 1985

The Journal of Physiology

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SUMMARY1. We monitored sweat secretion (using skin potential) and blood flow (using skin temperature) in the hind-paw skin of chloralose-anaesthetized cats pre-treated with guanethidine, and studied the responses to electrical stimulation of the ipsilateral lumbar sympathetic trunk.2. Stimulation caused sweat secretion and an increase in skin blood flow which was almost entirely restricted to the paw pads and was completely ipsilateral. Stimulation of the tibial nerve trunk produced similar effects, except that the increase in blood flow was more prolonged.3. The vasodilator effect of sympathetic trunk stimulation was not affected by chronic deafferentation of the paw.4. Atropine methonitrate (05-1 mg/kg i.v.) abolished the sudomotor response to sympathetic stimulation, but did not attenuate the blood flow response.5. Hexamethonium (1-2 mg/kg i.v.) abolished the vasodilator response to sympathetic stimulation, but did not affect the sudomotor response. Larger doses of hexamethonium (10-20 mg/kg) abolished both responses.6. The data suggest that the lumbar post-ganglionic neurones mediating vasodilatation in the skin of the cat paw pad are distinct from those that mediate sudomotor secretion.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, vasodilator nerves are known to supply the digital vasculature in a variety of avian species, where sweat glands are absent (Johansen & Millard, 1974;Bell & Rome, 1984), so similar neural populations might be expected to exist in mammals.…”

Section: Effects Of Acetylcholine Antagonists On Responses To Nerve Smentioning

confidence: 99%

Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation.

Bell¹,

Jänig²,

Kümmel³

et al. 1985

The Journal of Physiology

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“…An independent dopaminergic innervation in the main trunk and proximal branches of the mesenteric artery and renal artery is supported also by the studies ofYeh et al (1969), Goldberg (1972);Goldberg et al (1978), Lokhandwala & Buckley, (1977), Lokhandwala & Barrett, (1982), Kullman et al (1983) and Amenta et al (1984) which describe the presence of specific receptors for dopamine in these vascular areas, and by the presence of considerable concentrations of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in mesenteric and renal arteries (LackQvic et al, 1982). In addition it has been reported that other vascular and non-vascular peripheral tissues are supplied with nerves where the transmitter substance is dopamine (Bell et al, 1978 a,b;Bell & Rome, 1984;Commissiong et al, 1978;Dinerstein et al, 1979;Lackovic & Neff, 1980). Bell et al (1978a) and Dinerstein et al (1979) have shown the presence in dog kidney of dopamine-containing nerves which predominate in the cortical layer.…”

Section: Discussionmentioning

confidence: 99%

The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues

Caramona

Soares‐da‐Silva

1985

British J Pharmacology

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1 Dopamine, noradrenaline (NA) and adrenaline (Ad) depletion by 6-hydroxydopamine (6-OHDA) and pargyline plus 6-OHDA was investigated in the cat left ventricle, mesenteric and renal arteries, renal cortex, renal medulla and adrenal medulla. Catecholamine concentrations in plasma were also analyzed in these two experimental conditions. 2 6-OHDA alone or in combination with pargyline induced parallel decreases of NA and dopamine contents in the left ventricle. In the main trunk and proximal branches of the mesenteric artery and renal artery 6-OHDA selectively reduced NA without a parallel decrease in dopamine content. Previous treatment with pargyline abolished this selectivity. 3 In the kidney of control animals, dopamine content was greater than could be attributed to its presence only in noradrenergic neurones. In the renal cortex 6-OHDA reduced significantly dopamine and NA contents, and in the renal medulla only NA levels were decreased by this drug. Pargyline plus 6-OHDA did not deplete the NA content either in the renal cortex or in the renal medulla, and only reduced significantly the dopamine content in the renal cortex. 4 NA concentrations in plasma were increased by pargyline plus 6-OHDA whilst Ad remained unaffected. In the adrenal medulla only NA content was reduced either by 6-OHDA or pargyline plus 6-OHDA. 5 The present findings suggest a NA-independent dopamine pool in both segments of the mesenteric artery and renal artery but not in the left ventricle.

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Purinoceptors: Ontogeny and phylogeny

Burnstock

1996

Drug Dev. Res.

108

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Pharmacological investigations of the vasodilator nerves supplying the duck's foot

Cited by 13 publications

References 21 publications

Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation.

Differentiation of vasodilator and sudomotor responses in the cat paw pad to preganglionic sympathetic stimulation.

The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissues

Purinoceptors: Ontogeny and phylogeny

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