Pharmacological management of chronic obstructive pulmonary disease

Shaddock, Erica; Richards, Guy A.

doi:10.7196/samjnew.8426

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…It is suggested that repeat instructions can improve pMDI technique. [20,21] In a study by Weinberg and Naya, [20] pMDI technique improved from 32% to 86% by repeatedly reinforcing correct technique. In our study, we did not determine how often pMDI technique was assessed.…”

Section: Frequency Of Errors In Inhaler Technique (N=97)mentioning

confidence: 99%

Assessment of metered-dose inhaler technique: A study at the pulmonology clinic of a tertiary hospital in the Free State, South Africa

Ramkillawan

Prins

Rooyen

et al. 2019

Afr J Thorac Crit Care Med

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Background. Poor pressurised metered-dose inhaler (pMDI) technique remains a challenge in the management of airway diseases. Objectives. To assess pMDI technique among respiratory outpatients and identify the main indications for pMDI use and factors associated with improper use. Methods. This was a prospective, quantitative descriptive study conducted at the adult respiratory clinic of Universitas Academic Hospital in Bloemfontein, South Africa. A convenience sample of 100 participants was used. Each participant was interviewed and required to demonstrate the use of a placebo pMDI, either alone or with a large-volume spacer. Inhaler technique was evaluated according to the UK Inhaler Group standard for inhaler therapy. Results. Chronic obstructive pulmonary disease and asthma were the most common indications for pMDI use. Of the 100 participants, 97 preferred a pMDI without a spacer (pMDI alone) and three preferred using the inhaler with a spacer. In the pMDI-alone group, 13 participants (13.4%) demonstrated correct technique and 65 (67%) made more than one error. Conclusion. Poor inhaler technique is common among respiratory outpatients. Every contact with the patient should be an opportunity to reinforce correct pMDI technique.

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Section: Frequency Of Errors In Inhaler Technique (N=97)mentioning

confidence: 99%

Assessment of metered-dose inhaler technique: A study at the pulmonology clinic of a tertiary hospital in the Free State, South Africa

Ramkillawan

Prins

Rooyen

et al. 2019

Afr J Thorac Crit Care Med

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“…Glucocorticoids (GCs) steroid hormones released from the adrenal cortex as part of the stress response play an important role in a variety of bodily processes such as inflammation, immunity, and numerous metabolic processes [ 1 – 3 ]. Their varied effects allow for their clinical application in numerous diseases, particularly for their potent anti-inflammatory and immunosuppressive effects to treat diseases such as arthritis [ 4 , 5 ]. GCs are also prescribed for the treatment of lymphoid cancers, as they selectively induce cell death in leukocytes [ 6 – 8 ], highlighting the tissue specificity of their action and the need for further research into GC signalling.…”

Section: Introductionmentioning

confidence: 99%

Insight into glucocorticoid receptor signalling through interactome model analysis

et al. 2017

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Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research, high glucocorticoid efficacy and widespread usage in medicine, resistance, disease relapse and toxicity remain factors that need addressing. Understanding the mechanisms of glucocorticoid signalling and how resistance may arise is highly important towards improving therapy. To gain insight into this we undertook a systems biology approach, aiming to generate a Boolean model of the glucocorticoid receptor protein interaction network that encapsulates functional relationships between the GR, its target genes or genes that target GR, and the interactions between the genes that interact with the GR. This model named GEB052 consists of 52 nodes representing genes or proteins, the model input (GC) and model outputs (cell death and inflammation), connected by 241 logical interactions of activation or inhibition. 323 changes in the relationships between model constituents following in silico knockouts were uncovered, and steady-state analysis followed by cell-based microarray genome-wide model validation led to an average of 57% correct predictions, which was taken further by assessment of model predictions against patient microarray data. Lastly, semi-quantitative model analysis via microarray data superimposed onto the model with a score flow algorithm has also been performed, which demonstrated significantly higher correct prediction ratios (average of 80%), and the model has been assessed as a predictive clinical tool using published patient microarray data. In summary we present an in silico simulation of the glucocorticoid receptor interaction network, linked to downstream biological processes that can be analysed to uncover relationships between GR and its interactants. Ultimately the model provides a platform for future development both by directing laboratory research and allowing for incorporation of further components, encapsulating more interactions/genes involved in glucocorticoid receptor signalling.

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“…[2] There are many reasons for this, not least of which is the attitude of clinicians, which can often be fatalistic with regard to COPD. This edition of CME highlights key aspects of the diagnosis [3] and treatment -pharmacological [4] and non-pharmacological [5] and new developments in the management of severe disease. [6] Furthermore, we have included articles focusing on non-smokingrelated COPD [7] and tips for good spirometry.…”

mentioning

confidence: 99%

Chronic obstructive pulmonary disease in South Africa: Under-recognised and undertreated

Allwood

Zyl-Smit

2015

S Afr Med J

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Pharmacological management of chronic obstructive pulmonary disease

Cited by 4 publications

References 13 publications

Assessment of metered-dose inhaler technique: A study at the pulmonology clinic of a tertiary hospital in the Free State, South Africa

Assessment of metered-dose inhaler technique: A study at the pulmonology clinic of a tertiary hospital in the Free State, South Africa

Insight into glucocorticoid receptor signalling through interactome model analysis

Chronic obstructive pulmonary disease in South Africa: Under-recognised and undertreated

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