Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway

Cook, Sarah; Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Bates, Katie; Iakunchykova, Olena; Kontsevaya, A. V.; McKee, Martin; Schirmer, Henrik; Воевода, М. И.; Kudryavtsev, Alexander; Malyutina, Sofia; Leon, David A.

doi:10.1186/s12872-020-01513-1

Cited by 2 publications

(2 citation statements)

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“…Conversely, participants with hypertension and diabetes mellitus (DM) displayed comparatively higher rates of treatment. Despite our identification of low treatment rates for hypercholesterolemia and relatively favorable treatment rates for hypertension, prior studies report extremely low antihypertensive and lipid-lowering medication adherence in Russia [ 71 ]. On the other hand, self-medication for high blood pressure without having hypertension diagnosed by a doctor is an acknowledged problem in Russia because of the non-prescription sales of antihypertensives [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite our identification of low treatment rates for hypercholesterolemia and relatively favorable treatment rates for hypertension, prior studies report extremely low antihypertensive and lipid-lowering medication adherence in Russia [ 71 ]. On the other hand, self-medication for high blood pressure without having hypertension diagnosed by a doctor is an acknowledged problem in Russia because of the non-prescription sales of antihypertensives [ 71 ]. As for antidiabetics, their intake by those not aware of having DM might be explained by the common prescription of glucose-lowering medication to those at the so-called prediabetes stage [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

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Awareness of Hypertension, Hypercholesterolemia, and Diabetes Mellitus and Associated Characteristics in Russian Adults

Sahatqija,

Hunsberger,

Cook

et al. 2024

International Journal of Hypertension

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Russia has higher cardiovascular disease (CVD) mortality compared to other European countries. The major CVD risk factors are age, male sex, and three conditions, namely hypertension, hypercholesterolemia, and diabetes mellitus (DM). This study aimed to assess awareness of these three conditions among Russian adults (N = 3803) and the associated socio-demographic, lifestyle, and health characteristics. We used cross-sectional data from a randomly drawn population-based sample of Russians aged 35–69 years, who participated in the Know Your Heart (KYH) study conducted in Arkhangelsk and Novosibirsk between 2015–2018. Participants’ self-reported awareness of hypertension, hypercholesterolemia, and DM was assessed against the measures at the KYH health check (blood pressure, cholesterol, HbA1c and/or use of medication for each condition). Prevalence estimates for the awareness were age- and sex-standardized to the Standard European Population. Socio-demographic, lifestyle, and health-related correlates of the awareness were investigated using logistic regression modelling. Among participants with hypertension (N = 2206), hypercholesterolemia (N = 3171), and DM (N = 329) recorded at a health check, 79%, 45%, and 61% self-reported these conditions, respectively. Higher awareness of hypercholesterolemia and hypertension was associated with older age, female sex, nonsmoking status, obesity, and history of CVD diagnoses. Low household income and history of CVD diagnoses were associated with being aware of DM. The awareness rates of hypertension were relatively high, whereas awareness rates of hypercholesterolemia and DM were relatively low. CVD prevention and early intervention could be improved in Russia through increasing the awareness of the risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Awareness of Hypertension, Hypercholesterolemia, and Diabetes Mellitus and Associated Characteristics in Russian Adults

Sahatqija,

Hunsberger,

Cook

et al. 2024

International Journal of Hypertension

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Cardiac systolic and diastolic function in relation to cardiovascular risk factor distribution: a comparison of strain-rate imaging in Russian and Norwegian populations Heart-to-Heart: Norwegian-Russian multilevel educational collaboration in cardiovascular disease epidemiology

Rösner,

Kornev,

Caglayan

et al. 2024

Preprint

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Background: Cardiovascular morbidity and mortality rates are high in Russia and it is likely that this reflects a similar impact on the general cardiac health of the population. The current study seeks to compare standard echocardiography and strain-based measurements between Russian and Norwegian populations, while also exploring their links to hemodynamic and risk factors. Methods: This study included echocardiographic measurements of 1,192 participants from Arkhangelsk and Novosibirsk, Russia, and 917 from the Tromsø Study population, Norway. The sample included men and women aged 40–69 years. Normalcy, defined as the absence of hypertension or indicators of CVD, was observed in 840 individuals. We performed conventional echocardiography and analysed two-dimensional speckle-tracking longitudinal strains, including systolic, early-, and late-diastolic SR values. The study population was divided into four groups: normal, controlled hypertension, hypertensive blood pressure, and cardiac disease. Echocardiographic parameters were compared between the Russian and Norwegian populations,adjusted for age, sex, height, body mass index, blood pressure, heart rate (HR), atrial fibrillation (AF), smoking, pulmonary hypertension, and serum values for total, LDL (low density lipoprotein), and HDL (high density lipoprotein) cholesterol; triglycerides; creatinine; high-sensitivity C-reactive protein; and HbA1C. Results: Russians showed a tendency towards lower longitudinal systolic functional parameters, which were most prominent in the normotensive group. However, these differences became insignificant after adjusting for parameters that influence pre- and after-loads. Russians also had a lower stroke volume, higher HR, higher left atrial volume, lower A, and higher E/A ratio, indicating a higher incidence of diastolic dysfunction in the Russian population that persisted after adjustments. Conclusion: After adjusting for factors that influence cardiac function, there were no differences in systolic functional parameters betweenthe Norwegian and Russian populations. However, differences in diastolic parameters, which persisted after adjusting for conventionally influential factors, indicated unexplained underlying causes of diastolic dysfunction in the Russian population.

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Pharmacological management of modifiable cardiovascular risk factors (blood pressure and lipids) following diagnosis of myocardial infarction, stroke and diabetes: comparison between population-based studies in Russia and Norway

Cited by 2 publications

References 23 publications

Awareness of Hypertension, Hypercholesterolemia, and Diabetes Mellitus and Associated Characteristics in Russian Adults

Awareness of Hypertension, Hypercholesterolemia, and Diabetes Mellitus and Associated Characteristics in Russian Adults

Cardiac systolic and diastolic function in relation to cardiovascular risk factor distribution: a comparison of strain-rate imaging in Russian and Norwegian populations Heart-to-Heart: Norwegian-Russian multilevel educational collaboration in cardiovascular disease epidemiology

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