Pharmacological Management of Sjögren’s Syndrome

Ha, You‐Jung; Lee, Yun Jong

doi:10.1007/978-3-030-72029-2_11

Cited by 2 publications

(1 citation statement)

References 125 publications

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“…In cases of severe glandular or extraglandular manifestations, immunosuppressants such as hydroxychloroquine, methotrexate, and cyclophosphamide may be employed. Additionally, recent advances have introduced biologics like Rituximab for refractory cases, particularly when there are serious systemic complications [11].…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

ENT Manifestations of Sjögren’s Syndrome: A Comprehensive Narrative Review

Farrukh

2024

IJMBS

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Background: Sjögren's Syndrome (SjS) is a chronic autoimmune disorder predominantly affecting exocrine glands, leading to symptoms such as keratoconjunctivitis sicca and xerostomia. This review focuses on the ear, nose, and throat (ENT) manifestations of SjS, which significantly impact patient quality of life and pose diagnostic challenges. Aim: The review aims to consolidate current knowledge on the ENT manifestations of SjS, exploring pathophysiological underpinnings, clinical presentations, and treatment strategies, while addressing the diagnostic challenges associated with the disease. Review Summary: ENT manifestations in SjS include nasal dryness, recurrent sinusitis, otitis, and laryngeal dryness, which may precede other systemic manifestations, aiding in early diagnosis and management. This review highlights the importance of recognizing these symptoms for timely intervention, which can significantly improve disease prognosis. Future Implications: Understanding ENT manifestations can enhance multidisciplinary management approaches and foster development in diagnostic and therapeutic strategies, potentially improving patient outcomes and quality of life. Clinical Policy and Development: Enhanced awareness and training on the ENT aspects of SjS are recommended for healthcare professionals. Development of more sensitive diagnostic tools and personalized treatment plans could also address the variability in symptom presentation and response to treatment. Keywords: Sjögren's Syndrome, ENT Manifestations, Xerostomia, Keratoconjunctivitis Sicca, Multidisciplinary Management

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Section: Pharmacological Treatmentsmentioning

confidence: 99%

ENT Manifestations of Sjögren’s Syndrome: A Comprehensive Narrative Review

Farrukh

2024

IJMBS

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Salivary gland function, development, and regeneration

Chibly

Aure

Patel

et al. 2022

Physiological Reviews

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Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disease and injury will direct the development of therapy to repair and regenerate them. Significant recent advances, particularly in the OMICS field, increase our understanding of how salivary glands develop at the cellular, molecular and genetic levels; the signaling pathways involved, the dynamics of progenitor cell lineages in development, homeostasis and regeneration and the role of the extracellular matrix microenvironment. These provide a template for cell and gene therapies as well as bioengineering approaches to repair or regenerate salivary function.

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Pharmacological Management of Sjögren’s Syndrome

Cited by 2 publications

References 125 publications

ENT Manifestations of Sjögren’s Syndrome: A Comprehensive Narrative Review

ENT Manifestations of Sjögren’s Syndrome: A Comprehensive Narrative Review

Salivary gland function, development, and regeneration

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