Pharmacological modulation of HIF-1 in the treatment of neuropsychiatric disorders

Sharma, Diksha; Khan, Heena; Kumar, Amit; Grewal, Amarjot Kaur; Dua, Kamal; Singh, Thakur Gurjeet

doi:10.1007/s00702-023-02698-3

Cited by 6 publications

(1 citation statement)

References 88 publications

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“…According to recent data, increased CO 2 (PCO 2 ≈ 50 mmHg) levels under intermittent hypercapnic–hypoxic exposure have a positive effect on a number of key gero-protective molecular cellular mechanisms [ 48 ]. Among these mechanisms, a number of researchers highlight the active activation of angiogenesis [ 49 , 50 , 51 ]. In this case, a 2-week course of daily 20-min exposure to hypercapnic hypoxia (PO 2 ≈ 90 mmHg and PCO 2 ≈ 50 mmHg) activates neo-angiogenesis signaling pathways mediated by increased levels of VEGF in the body [ 52 ].…”

Section: Signaling Pathways Of the Gero-protective Potential Of Inter...mentioning

confidence: 99%

Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy

Tregub,

Komleva,

Kulikov

et al. 2024

IJMS

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The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent hypercapnic–hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic–hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic–hypoxic training methods.

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