Pharmacological modulation of inflammatory oligodendrocyte progenitor cells using three multiple sclerosis disease modifying therapies in vitro

Developing drugs that promote remyelination: Is our in vitro screening approach too simplistic?

“…In this issue of Neurotherapeutics , Jank and colleagues present experiments that highlight the need to assess the effects of DMTs on remyelination and challenge the standard approach to screening drugs in vitro for their potential to promote remyelination in MS [ 17 ]. Their investigation sought to address two critical issues.…”