Pharmacological, nutritional, and analytical aspects of β-sitosterol: a review

Ambavade, Shirishkumar D.; Misar, Ashwini; Ambavade, Prashant D.

doi:10.1007/s13596-014-0151-9

Cited by 52 publications

(28 citation statements)

References 170 publications

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“…HPTLC analysis of β-amyrin, β-sitosterol, lupeol and ursolic acid strongly supported the anti-HBV efficacy of GSLE via abating the cellular oxidative stress molecules [27]. There are many studies that have reported the antioxidant activity of β-sitosterol [27][28][29][30][31][32][33][34].…”

Section: β-Sitosterol As Immunostimulant As Antiviral and As Antioxidantmentioning

confidence: 97%

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

2020

Arch Pharmacol Ther

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Potential Inhibitor of SARS-CoV-2 M pro (COVID-19)", we have investigated the role of β-sitosterol as immunostimulant, antioxidant and inhibitory potential against Receptor Binding Domain (RBD) of SARS-CoV-2 Spike Glycoprotein with the aid of molecular docking. There are many studies which reveals the antioxidant and immune boosting role of β-sitosterol especially in viral infection including pneumoniae. This commentary emphasis on further potential of β-sitosterol in treatment of COVID-19 through molecular docking studies. We have targeted RBD of spike glycoprotein and performed molecular docking studies of β-sitosterol to find out its inhibitory potential of SARS-CoV-2. β-sitosterol have showed binding affinity -7.8 kcal/mol with 0 RMSD lower and upper bound. It formed one hydrogen bond with Ala-B:419 with bond length of 2.16A 0 . β-sitosterol has formed five alkyl bonds with Pro-C:384 (5.0A 0 , 4.66A 0 , 5.23A 0 , 4.27A 0 ) and with Lys-C:378 (4.66A 0 ). From present commentary, we have concluded that β-sitosterol can be used to enhance immunity against the SARS-CoV-2 infection as well as to restrict the viral invasion into the host cell through angiotensin converting enzyme-2 (ACE-2) by inhibiting spike glycoprotein. If we can increase the dietary intake of β-sitosterol and other phytosterols it can modulate the immunity which is todays need to face COVID-19.

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Section: β-Sitosterol As Immunostimulant As Antiviral and As Antioxidantmentioning

confidence: 97%

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

2020

Arch Pharmacol Ther

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“…Most of these ingredients possess potent pharmacological activity. For example, β-sitosterol has good anti-oxidation and anti-inflammatory effects [21,22], luteolin has antibacterial, anti-oxidant, and other broad biological and pharmacological properties [23], and kaempferol has an anti-inflammatory effect [24], and naringenin was determined to be the quality markers of Rhizoma drynariae in the Chinese Pharmacopoeia (the State Pharmacopoeia Commission of China, 2015). The OB of these compounds varies greatly, presenting an approximately normal distribution, mostly concentrated at about 40%, and the OB is generally inversely proportional to the molecular weight (MW).…”

Section: Resultsmentioning

confidence: 99%

Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma drynariae Against Osteoporosis

Gan

Chen

et al. 2019

Med Sci Monit

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Rhizoma drynariae is the main traditional Chinese medicine used for the treatment of osteoporosis, but its anti-osteoporotic targeting mechanism has not been fully elucidated due to the complexity of its active ingredients. In this study, the pharmacological mechanism of action of Rhizoma drynariae against osteoporosis was studied by integrating pharmacological concepts. The pharmacokinetic characteristics of selected major active constituents of Rhizoma drynariae and the SMILES structural similarity were used to predict related targets. A literature search was conducted to identify known osteoporosis treatment targets, which were then combined with the predicted targets to construct the direct or indirect target interaction network map of Rhizoma drynariae against osteoporosis. Finally, data on the key targets of the interactions, ranked according to relevant node parameters obtained through pathway enrichment analysis and screening of key targets and active ingredients of Rhizoma drynariae , were used to perform molecular docking simulation. We screened 16 active ingredients of Rhizoma drynariae , and 7 key targets with direct or indirect effects with a high frequency were obtained. These main pathways were found to play important roles in the PI3k-akt signaling pathway, osteoclast differentiation, Wnt signaling pathway, and estrogen signaling pathway. Molecular docking showed that most active ingredients of Rhizoma drynariae had strong binding efficiency with key targets. Based on network pharmacology, we conclude that Rhizoma drynariae plays an anti-osteoporotic role by directly or indirectly targeting multiple major signaling pathways and influencing the proliferation and differentiation of multiple types of cells.

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“…As for the relation of these sterols to health, studies have shown that the effects of sterols of olive oil are attributed to β sitosterol, the main sterol of olive oil, It decreases the level of LDL cholesterol, opposes the intestinal absorption of cholesterol, has antitumor activity and plays a role in the prevention of certain cancers (prostate, colon) 31 . On the other hand, Δ5-Avenasterol is associated with antioxidant activity The aliphatic alcohol composition of the three varieties exceeds the limit laid down by the EEC regulation, namely 6,05% for Bouricha; 10.43% for Limli and 9.94% for Blanquette (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Analysis of bioactive minor compounds in three olive oils from varieties of olive tree eastern Algerian (Bouricha, Limli and Blanquette).

Benrachou¹,

lynda²,

Henchiri

2016

JNR

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The study of bioactive compounds on the health of the unsaponifiable fraction of three olive oils from three cultivars of eastern Algeria carried out by gas chromatography revealed the presence of 11 compounds with the predominance of b-Sitosterol, Sterol characteristic of olive oils and having a nutritional and pharmacological value. The highest content was found in Limli oil (81.59%). Two triterpene dialcohols were chromatographed with sterols (erythrodiol and uvaol), the content of which can be identified fraud and to detect whether the virgin oil is mixed with the oil of pomace. Analysis of the alcohol fraction by GPC-FID revealed the predominance of a triterpene alcohol, 24-methylene cycloarenol for the three varieties with a higher content for Blanquette (48.03%) followed by cycloarenol. For the aliphatic alcohols, the analysis shows the predominance of four alcohols with 22, 23, 24 and 28 carbon atoms whose contents are higher for Limli oil. The spectrophotometric determination of antioxidant pigments shows that Limli oil is richer in chlorophylls with an average of 13.53 mg / kg and a significantly higher carotenoid content for Bouricha and Limli (13.10 -12.82 mg / Kg). The total polyphenols were lower for Blanquette (83.36 mg / kg) compared with Bouricha and Limli (133.3 mg / kg and 121.3 mg / kg), making them more stable during oxidation storage and whose beneficial effects of olive oil are mainly attributed to these substances, in particular the antioxidant action that would protect against diseases of oxidative stress.

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Pharmacological, nutritional, and analytical aspects of β-sitosterol: a review

Cited by 52 publications

References 170 publications

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein

Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma drynariae Against Osteoporosis

Analysis of bioactive minor compounds in three olive oils from varieties of olive tree eastern Algerian (Bouricha, Limli and Blanquette).

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