Pharmacological performance of novel poly-(ionic liquid)-grafted chitosan-N-salicylidene Schiff bases and their complexes

Introduction Chitosan (CS) is one of the most readily available biopolymer due to preparing it from alkaline N-deacetylation of Chitin, which is the most plentiful polysaccharide in nature. The structure of chitosan is a linear co-biopolymer of 2-acetamido-2-deoxy-β-Dglucopyranose(GluNHAc) with2-amino-2-deoxy-β-D-glycopyranose (GluNH 2) (Rinaudo, M., 2006).Due to the unique properties of chitosan such as a biocompatibility, biodegradability and also its antimicrobial and anti-cancer activity (Choi et al., 2001,Chung et al., 2012,Foster et al., 2015,Xia et al., 2011),CS is very attractive for many applications in the pharmaceutical, agricultural, food, textiles and medical fields and cosmetic industries and a treatment for waste water (Crini, G., 2006, Khor et al., 2003, Miretzky et al., 2009). Moreover, many studies have shown that the modification of chitosan via Schiff bases condensation between primary amines and aldehydes increases its biological activity.

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“…That is due to appearance of azomethine bond (-C=N) (Verlee et al, 2017, Elshaarawy et al, 2016, Raman et al, 2011, Salama et al, 2015.…”

mentioning

confidence: 99%

Tetrabutylphosphonium-salicyl-imine-chitosan metallo-Schiff bases:Supramolecular architectures as multifunctional pharmacological materials.

Seif

Elshaarawy

El‐Naggar

et al. 2019

Journal of Scientific Research in Science

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“…Recently, a new class of pharmacological entity was developed by salicylidene IL assisted functionalization of biopolymeric chitosan Schiff bases and appraised for their in vitro antimicrobial, against fungal pathogens and common bacterial, and anticancer action against human colon carcinoma cell line (HCT‐116). Structure–activity relationship for fabricated compounds against HCT‐116 cell lines indicated that the antitumor capability of metal complexes were superior to that of the parent ligand . In spite of the impressive attributes of ILs, the widespread commercial employment of ILs for biomedical applications at bulk scale can be hampered due to highly corrosive nature of ILs compared to ordinary solvents .…”

Section: Ils‐assisted Processing Of Biopolymers For Biomedical Applicmentioning

confidence: 99%

“…Structure-activity relationship for fabricated compounds against HCT-116 cell lines indicated that the antitumor capability of metal complexes were superior to that of the parent ligand. [64] In spite of the impressive attributes of ILs, the widespread commercial employment of ILs for biomedical applications at bulk scale can be hampered due to highly corrosive nature of ILs compared to ordinary solvents. [65] This additional drawback can significantly increase the costs of industrial processes involving ILs as special expensive steels vessels would be essential.…”

Section: Ils-assisted Processing Of Biopolymers For Biomedical Applicmentioning

confidence: 99%

Recent Advances of Using Ionic Liquids for Biopolymer Extraction and Processing

Mahmood

Moniruzzaman

2019

Biotechnology Journal

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The evolution of petroleum‐derived polymers is one of the crowning accomplishments of the past century. Although the significant economic gains from this industrial model of resource utilization are achieved, the environmental impacts are fatal. One of the principles of sustainable development is to replace such polymers with potential alternatives derived from renewable materials. Biopolymers derived from natural resources afford a new, versatile, environmentally benign feedstock that could exhibit closed‐loop life cycles as part of a future material's industrial ecology. However, the solubility and processability of biopolymer materials provoke a serious bottleneck owing to their dense networks of inter ‐ and intramolecular bondings and structural heterogeneity. Recently, ionic liquids (ILs) have emerged as promising green solvents and acquired augmented appreciation for their peerless power of biopolymer processing. Among the fourteen principle of green chemistry, the two key elements encourage the exploitation of renewable raw materials by using environmentally benign solvents that cover in dissolution of biopolymers using ILs. This mini review represents a brief overview of the comprehensive ILs assisted extraction and processing of various biopolymeric materials for value‐added applications.

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“…Because of their various oxidation states which facilitate their structural flexibility, spectroscopic, stereochemical, magnetic and electrochemical properties, the first‐row transition elements play a vital role in the synthesis of several coordination complexes. Among the first row transition metals, Co(II), Ni(II), Cu(II) and Zn(II) with Schiff bases were reported to show important role and a wide range of biological and pharmaceutical applications …”

Section: Introductionmentioning

confidence: 99%

Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Aziz

Seda

2017

Applied Organom Chemis

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The tetradentate Schiff base ligand (SB), N,N′-bis-(2-mercaptophenylimine)-2,5thiophenedicarboxaldehyde was prepared via condensation of 2,5-thiophenedicarboxaldehyde with 2-aminothiophenol in a 1:2 molar ratio by conventional method. Additionally, its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized and fully characterized by elemental analysis, FT-IR, 1 H NMR, 13 C NMR, UV-Vis, ESR, ESI-mass, conductivity and magnetic susceptibility measurements. Spectral studies suggested that, the Schiff base coordinate metal ions through the azomethine N-and deprotonated thiol S-atoms. Based on UV-Vis absorption and magnetic susceptibility data, tetrahedral geometry was assigned for both Co(II) and Zn(II) complexes, whereas on the other hand, square planar geometry for both Ni(II) and Cu(II) complexes. The Schiff base and its metal complexes were screened for their in vitro antimicrobial activity by minimum inhibitory concentration (MIC) method. Free radical scavenging activity of the novel compounds was determined by elimination of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. In addition, the interactions of the free ligand and its complexes with calf thymus DNA (CT-DNA) were explored using absorption, emission and viscosity measurements techniques.

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Pharmacological performance of novel poly-(ionic liquid)-grafted chitosan-N-salicylidene Schiff bases and their complexes

Cited by 70 publications

References 43 publications

Tetrabutylphosphonium-salicyl-imine-chitosan metallo-Schiff bases:Supramolecular architectures as multifunctional pharmacological materials.

Tetrabutylphosphonium-salicyl-imine-chitosan metallo-Schiff bases:Supramolecular architectures as multifunctional pharmacological materials.

Recent Advances of Using Ionic Liquids for Biopolymer Extraction and Processing

Synthesis, structural features and biochemical activity assessment of N,N′‐bis‐(2‐mercaptophenylimine)‐2,5‐thiophenedicarboxaldehyde Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

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