Pharmacological potentials of Premna integrifolia L.

Mali, Prashant

doi:10.4103/0257-7941.179864

Cited by 20 publications

(17 citation statements)

References 19 publications

(21 reference statements)

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“…Due to the emergence of anti-microbial resistance, it is not surprising to find resistance to amoxicillin in S. aureus isolates from mastitic milk samples of dairy bovines [4,5]. Though antibacterial activity was reported with different extracts of Premna integrifolia [11,[15][16][17], in the present study both the leaf and root aqueous extracts of the plant didn't show any antimicrobial activity against all the isolates of S. aureus. This may be due to use of different solvent in the process of extraction.…”

Section: Discussioncontrasting

confidence: 55%

“…In this context exploration of natural compounds from medicinal plants that exhibit both antibacterial and anti-inflammatory/immunomodulatory properties may offer promising solution for therapeutic approach to mastitis in dairy animals. Medicinal uses of the plant Premna integrifolia that has prominent value in Indian system of medicine Ayurveda was reviewed by different researchers [9][10][11]. Reports on increased sensitivity of bacterial pathogens to antibiotics, when used in combination with anti-inflammatory compounds like Non-Steroidal Anti-inflammatory Drugs (NSAIDs) [12], also encourages us to take up research work on the natural compounds with antiinflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

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Exploration of Antibacterial and Anti-inflammatory Activities of Premna integrifolia Plant Extracts in Bubaline Mastitis

Reddanna

2018

JCMAH

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Mastitis, which affects the milk production of dairy animals, is usually due to mammary gland invasion by bacterial pathogens. Emergence of antimicrobial resistance in bacteria and side effects associated with the use of anti-inflammatory cortisones in mastitis prompted for use of alternate/complementary therapeutics. As the plant Premna integrifolia was reported to exhibit antibacterial, anti-inflammatory/ immunomodulatory properties, its leaf and root aqueous extracts were tested for their antibacterial activity against Staphylococcus aureus and Escherichia coli, either individually or in combination with the antibiotics. The anti-inflammatory properties of the extracts were also tested against the bubaline mammary epithelial cells (MEC) infected with S. aureus and E. coli. In microbroth dilution assays for assessing minimum inhibitory concentration (MIC) in vitro, the leaf and root extracts of Premna integrifolia didn't exhibit any antimicrobial activity against S. aureus but showed significant antimicrobial activity on E. coli. In combination with the plant extract, the sensitivity of S. aureus to amoxicillin is not only increased but also the S. aureus isolates that were resistant to amoxicillin also became sensitive. The Premna integrifolia leaf and root extracts, however, showed antagonism on antimicrobial activity of enrofloxacin in combination. In addition the aqueous root extract of Premna integrifolia exhibited anti-inflammatory activity through down regulation of cytokines IL-6, IL-8 and TNF-α in S. aureus and IL-6 and IL-8 in E. coli infected MEC. These studies reveal antimicrobial activity of leaf and root extracts of Premna integrifolia on E. coli. In combination with amoxicillin these plant extracts increased the sensitivity of S. aureus to amoxicillin. The anti-inflammatory activity of root extract of Premna integrifolia on MEC infected with S. aureus and E. coli is also demonstrated in these studies.

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Section: Discussioncontrasting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Exploration of Antibacterial and Anti-inflammatory Activities of Premna integrifolia Plant Extracts in Bubaline Mastitis

Reddanna

2018

JCMAH

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“…Therefore, it is necessary to perform a novel study to substantiate its local use as a nutraceutical leafy vegetable. [7][8] The objectives of this study were to investigate the α-glucosidase inhibitory and antioxidant activities of infusion and decoction from leaves of P. serratifolia. The leaf extracts were analyzed for their total phenolic content and LC-MS profiles.…”

Section: Introductionmentioning

confidence: 99%

Chemical Characteristics and In vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction

Timotius¹,

Simamora²,

Santoso³

2018

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Introduction: Leaves of Premna serratifolia L. (local name: arogo) is well known as food ingredient for fish/meat-based soup in Tentena, Indonesia. Evaluation of its bioactivities is needed. Objective: This study aimed to evaluate the α-glucosidase inhibitory and antioxidant activities of infusion and decoction of P. serratifolia leaves. Methods: The leaf samples were prepared by infusion and decoction and analysed for their α-glucosidase inhibitory and antioxidant activities, as well as total phenolic contents and LC-MS profiles. Results: The total phenolic content of the decoction was higher than the infusion. The UV spectra of both infusion and decoction showed peak at 325 nm and shoulder at 285 nm. Their LC-MS yielded one dominant component at 132 (100) m/z fragment, which was tentatively identified as caffeic acid. Both infusion and decoction extracts exhibited strong α-glucosidase inhibition with IC 50 of 4.27 and 0.046 µg GAE/ml, respectively. The IC 50 for DPPH scavenging activity of the infusion and decoction were similar; 6.82 and 7.28 μg GAE/ml, respectively. But the IC 50 of the infusion and decoction for ferrous ion chelating activities were different; 161.66 and 28.34 μg GAE/ ml, respectively. The α-glucosidase inhibitory and antioxidant activities were related to the phenolic content. Conclusion: The study concludes that both infusion and decoction of arogo leaves have antidiabetic effect and potential antioxidant activity. The decoction of the leaves may increase its antidiabetic capacity.

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“…Anti microbial, Immunomodulatory, antiinflammatory [6] 3 Syonaka Oroxylum indicum (L)Benth ex Kurz. Bignonaceae…”

Section: Results and Discussion Pharmacological Properties Of Each Inmentioning

confidence: 99%

Critical Review on Agasthyahareetaki Avaleha With Special Reference to Swasahara Karma

Nithya

Indulekha

2020

Int J Ayu Pharm Res

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Respiratory disorders are one of the leading causes of morbidity worldwide. In Ayurvedic classics many poly herbal preparations are mentioned for curing respiratory disorders. Agasthyahareetaki avaleha is one such formulation mentioned in classical text books specially indicated for curing Swasa, Kasa, Vishamajvara etc. A detailed literature survey has been conducted to explore the probable mode of action of Agasthyahareetaki Avaleha in Swasa Roga. Most of the ingredients are having anti asthmatic, anti-inflammatory, immune modulator and antimicrobial activities may works on respiratory pathology. Apart from this Katu, Tikta Rasa, Ruksa, Lagu Guna and Kaphavata hara, Swasa- Kasa- Sopha Hara property of ingredients will hamper the pathology of Swasaroga.

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Pharmacological potentials of Premna integrifolia L.

Cited by 20 publications

References 19 publications

Exploration of Antibacterial and Anti-inflammatory Activities of Premna integrifolia Plant Extracts in Bubaline Mastitis

Exploration of Antibacterial and Anti-inflammatory Activities of Premna integrifolia Plant Extracts in Bubaline Mastitis

Chemical Characteristics and In vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction

Critical Review on Agasthyahareetaki Avaleha With Special Reference to Swasahara Karma

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