2002
DOI: 10.1093/bja/89.3.486
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Pharmacological preconditioning: comparison of desflurane, sevoflurane, isoflurane and halothane in rabbit myocardium

Abstract: Halothane, isoflurane and desflurane induced pharmacological preconditioning, whereas sevoflurane had no significant effect. In this preparation, desflurane was the most effective agent at preconditioning the myocardium against ischaemia.

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Cited by 58 publications
(53 citation statements)
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“…anesthetics can induce the cardioprotective effect of both preconditioning (6,18,19,24,27) and postconditioning (4,8,28). Because the primary end point of the present study was the assessment of cardioprotection, we felt it was important to avoid the confounding factors that are associated with anesthetics and open-chest animal models.…”
Section: Discussionmentioning
confidence: 99%
“…anesthetics can induce the cardioprotective effect of both preconditioning (6,18,19,24,27) and postconditioning (4,8,28). Because the primary end point of the present study was the assessment of cardioprotection, we felt it was important to avoid the confounding factors that are associated with anesthetics and open-chest animal models.…”
Section: Discussionmentioning
confidence: 99%
“…Its value as compared with administration of drugs, like anesthetics, 21 needs to be determined. This also holds for the possibility to combine dys-synchrony-induced preconditioning with other triggers to increase the protective effect, as shown for combining ischemic preconditioning with drug administration.…”
Section: Potential Clinical Applicationmentioning
confidence: 99%
“…4) The adaptive phenomenon, in which short episodes of ischemia protect myocardium from deleterious eŠects of subsequent more prolonged ischemia and reperfusion, has been termed as`I schemic Preconditioning''. Many pharmacological interventions such as endotoxin, 5) monophosphoryl lipid A, 6) interleukin-1, 7) A1 receptor agonist, 8) angiotensin, 9) bradykinin, 10) morphine, 11) endothelin-1, 12) hydrogen peroxide, 13) volatile anesthetics such as halothane, 14) des‰urane, iso‰urane, 15) and sevo‰urane 16) have been observed to produce ischemic preconditioning like protection of heart. These conditions to protect subsequent ischemia have been termed as pharmacological preconditioning.…”
Section: Introductionmentioning
confidence: 99%