Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

Effect of Rizatriptan and Other Triptans on the Nausea Symptom of Migraine: A Post Hoc Analysis

“…Activation of central 5-HT 1A receptors by compounds such as flesinoxan or ipsapirone causes nausea, 18,19 but it is also true that some pure 5-HT 1A agonists can have antiemetic effects in preclinical models. 20 In this analysis, only a minority of patients experienced emergence of nausea after taking treatment. Most of the triptans studied did not differ from placebo in emergence of nausea, and there were no consistent differences among the triptans.…”

“…The role of these different 5‐HT 1 receptor subtypes in nausea is unclear at present. Activation of central 5‐HT 1A receptors by compounds such as flesinoxan or ipsapirone causes nausea, 18,19 but it is also true that some pure 5‐HT 1A agonists can have antiemetic effects in preclinical models 20 …”

Ruthenium-Catalyzed Cross-Coupling of 7-Azabenzonorbornadienes with Alkynes. An Entry to 3a,9b-Dihydrobenzo[g]indoles

“…The widespread indole nucleus present in natural products, as well as in therapeutic agents, still remains one of the most attractive targets in heterocyclic synthesis. Besides traditional synthetic routes, transition-metal-catalyzed methods 4 provided remarkable improvements regarding efficiency, structural variations, and functional group compatibility to this important class of heterocycles.…”