Pharmacological properties and therapeutic potential of honey bee venom

Ullah, Amjad; Aldakheel, Fahad M.; Anjum, Syed Ishtiaq; Raza, Ghulam; Khan, Saeed; Gajger, Ivana Tlak

doi:10.1016/j.jsps.2022.11.008

Cited by 25 publications

(38 citation statements)

References 155 publications

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“…Honeybee venom (also known as apitoxin) is a complex biogenic mixture that is produced in the venom gland of honeybees and has several pharmaceutical and medical properties [87][88][89]. It is composed of water (88%) and various substances, including peptides and enzymes (such as esterase and protease), while melittin (one of the antimicrobial peptides) is the most effective and powerful agent [90][91][92].…”

Section: Bee Venommentioning

confidence: 99%

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Abd El-Aziz,

Abo Ghanima,

Mota-Rojas

et al. 2023

Animals

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Poultry and rabbit production are important and rapidly growing agricultural subsectors, particularly in several developing countries. To ensure the sustainability of poultry and rabbit production, realistic poultry and rabbit farming practices must be improved. Apitherapy is a traditional alternative medicine that involves the prevention and treatment of some diseases with several bee products including propolis, royal jelly, pollen, and venom. More feeding investigations on the numerous benefits of bee products for poultry and rabbits are crucial to be addressed. Poultry and rabbit production has recently experienced numerous challenges, including climate change, disease spread, and antibiotic misuse. Improving animal welfare, health, and production is a top priority for all livestock farms, as is supplying consumers with safe and healthy products. Therefore, this review aims to collect and investigate recent relevant literature on the use of bee products, as feed additives, drinking water supplements, and injections, for poultry and rabbits to improve animal health and production. From the current findings, bee products can improve the growth and immunological performance of small-livestock animals, such as poultry and rabbits, by activating digestive enzymes, maintaining microbial balance, and promoting vitamin synthesis. Therefore, bee products could be a promising natural alternative to growth promoters, reproductive stimulants, and immunological enhancers in poultry and rabbit farms to provide safe and healthy products for humans.

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Section: Bee Venommentioning

confidence: 99%

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Abd El-Aziz,

Abo Ghanima,

Mota-Rojas

et al. 2023

Animals

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“…Among the several natural compounds that have found their place in Oriental and alternative medicine, toxins isolated from a large number of organisms have had their application for many years, the most important being bee venom (BV) isolated from Apis mellifera ( Figure 1 A) [ 3 , 12 , 16 , 17 ]. Numerous studies speak in favor of the positive properties of BV, which include its radioprotective [ 18 , 19 , 20 ], antimutagenic [ 21 , 22 ], anti-inflammatory [ 23 , 24 ], antinociceptive [ 24 , 25 ], and antimicrobial [ 26 , 27 ] properties.…”

Section: Introductionmentioning

confidence: 99%

“…Different animal toxins isolated from spiders, scorpions, snakes, snails, sea urchins, and corals can kill cancer cells [ 1 , 12 , 15 , 38 , 39 , 40 , 41 , 42 ]. Furthermore, in recent years growing importance has been given to bee products, especially BV, which is used for a variety of medicinal purposes [ 12 , 16 , 21 , 22 , 35 ]. The use of bee products for preventing and treating many different diseases is referred to as apitherapy.…”

Section: Introductionmentioning

confidence: 99%

“…The use of bee products for preventing and treating many different diseases is referred to as apitherapy. The use of natural products and their active ingredients in the prevention and treatment of chronic diseases is largely based on the experience of the traditional medical system found in different ethnic communities and epidemiological data of the relationship between diet and disease [ 12 , 21 , 35 , 36 ]. Although Apis mellifera venom has been studied the most extensively, there are several other Apis species, namely, Apis cerana and Apis florea , whose venom and/or peptides have also shown promising pharmacological effects and anticancer properties [ 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

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Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). Previous studies have indicated that BV and its major constituent MEL cause a strong toxic effect on different cancer cells, such as liver, lung, bladder, kidney, prostate, breast, and leukemia cells, while a less pronounced effect was observed in normal non-target cells. Their proposed mechanisms of action, such as the effect on proliferation and growth inhibition, cell cycle alterations, and induction of cell death through several cancer cell death mechanisms, are associated with the activation of phospholipase A2 (PLA2), caspases, and matrix metalloproteinases that destroy cancer cells. Numerous cellular effects of BV and MEL need to be elucidated on the molecular level, while the key issue has to do with the trigger of the apoptotic cascade. Apoptosis could be either a consequence of the plasmatic membrane fenestration or the result of the direct interaction of the BV components with pro-apoptotic and anti-apoptotic factors. The interaction of BV peptides and enzymes with the plasma membrane is a crucial step in the whole process. However, before its possible application as a remedy, it is crucial to identify the correct route of exposure and dosage of BV and MEL for potential therapeutic use as well as potential side effects on normal cells and tissues to avoid any possible adverse event.

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“…Due to its widespread medicinal applications and other commercial products, bee venom is one of the sources of economic gain for beekeepers (Kim, 2021;von Reumont et al, 2022 andUllah et al, 2023). The venom glands of honeybees actively secrete a large amount of venom, which helps with colony defense and social immunity (Haggag et al, 2015;Omar, 2020 andSeyam et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Impact of Bee Venom Collector Equipment Positions on The Productivity of Venom Extracted from Carniolan, Buckfast, and Italian Honeybee Hybrids in Upper Egypt

Amro

Mohamed

2023

Egyptian Academic Journal of Biological Sciences. A, Entomology

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The honeybee venom productivity was evaluated between three honeybee hybrids i.e. Carniolan (Apis mellifera carnica), Buckfast (Apis mellifera buckfast) and Italian (Apis mellifera ligustica) during 2022 summer season in Assiut area, Upper Egypt. Bee venom was extracted from colonies using bee venom collecting equipment with an electronic impulse generator for colony stimulation. The efficiency of three positions of venom collector trap namely, front drawer venom trap (FDVT), bottom brood nest venom trap (BBNVT) and above brood nest venom traps (ABNVT) were evaluated. The Carniolan bees showed a non-significant amount of produced venom compared with Buckfast. However, it showed a highly significant venom amount when compared with the Italian hybrid. The obtained data indicated that in the case of using ABNVT, a significantly high amount of bee venom was collected (2.30, 2.00, 1.78 g/colony/day) followed by FDVT with, (1.97, 1.88, 1.52 g/colony/day) while BBNVT, enables bees to collect the lowest amount of venom (1.03. 0.95, 0.64 g/colony) by Carniolan, Buckfast and Italian honeybee colonies, respectively. The highest amount of bee venom collected during summer season was recorded between 10-20 July and followed by 17-31 August. However, the lowest amount of bee venom collected by the traps was recorded during the first two weeks of September for all tested honeybee hybrids. In conclusion, reliance on Carniolan and Buckfast hybrid bees may meet the requirements of beekeepers to produce satisfied quantities of bee venom with a distinct preference for using pollen traps above the brood nest to enhance venom production.

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Pharmacological properties and therapeutic potential of honey bee venom

Cited by 25 publications

References 155 publications

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Bee Products for Poultry and Rabbits: Current Challenges and Perspectives

Bee Venom: Composition and Anticancer Properties

Impact of Bee Venom Collector Equipment Positions on The Productivity of Venom Extracted from Carniolan, Buckfast, and Italian Honeybee Hybrids in Upper Egypt

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