Pharmacological properties of cashew (Anacardium occidentale)

Leite, Aracelli de Sousa; Islam, Md. Torequl; Junior, Antonio Luiz Gomes; Sousa, João Marcelo de Castro e; Alencar, Marcus Viní­cius Oliveira Barros de; Paz, Márcia Fernanda Correia Jardim; Rolim, Hercí­lia Maria Lins; Medeiros, Maria das Graças Freire de; Melo-Cavalcante, Ana A.C.; Lopes, José Arimateia Dantas

doi:10.5897/ajb2015.15051

Cited by 33 publications

(16 citation statements)

References 102 publications

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“…Almost all the chemical elements detected by Zuharah et al (2021) were also observed in the extract of this plant. Recently, the work of Aracelli de Sousa (Aracelli et al, 2016) conducted in Brazil, also revealed that A. occidentale contained high proportions of phenolic compounds. Beyond the phytochemicals detected, the analyses performed showed that the extract of A. occidentale presented the strongest capacities with respect to antioxidant activity, inhibition of anti-acetylcholinesterase, anti-butyrylcholinesterase and tyrosinase.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast

Bini

Kobenan

Kouakou

et al. 2023

Arch Insect Biochem Physiol

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In the context of climate change, the Ivorian cotton industry is facing with the loss of sensitivity of pests (Helicoverpa armigera) and the appearance of new so‐called emerging insects. Faced with this situation, cotton producers tend to use insecticide products in high doses, in excess of the norm. However, the misuse of chemical products poses many health risks. Therefore, to limit the use of chemicals, aqueous extracts of local plants with insecticidal properties were examined in the laboratory and in the field. Four local plant species were selected [Anacardium occidentale (Anarcardier); Azadirachta indica (Neem); Hyptis suaveolens (Hyptis) and Tephrosia vogelii (Tephrosia)]. After determining the chemical profiles of the four extracts by high performance liquid chromatography (HPLC)‐mass spectrometry, their inhibitory activities were assessed in cholinesterase and tyrosinase. The sensitivity of Helicoverpa armigera larvae was evaluated by ingesting the aqueous extracts at several concentrations ranging from 2% to 64% in an artificial nutrient substrate. Then, the mortality rates of the larvae during 72 h were evaluated and the lethal concentrations were determined. The results of chemical analyses (HPLC) showed that the richest aqueous extract in phytochemicals with 54 elements detected was that of cashew (A. occidentale). T. vogelii, A. indica and H. suaveolens presented 44, 45, and 39 chemical compounds, respectively. In addition, the total phenolic content was higher in A. occidentale (110.67 mg gallic acid equivalents/g) followed by A. indica (42.43 mg gallic acid equivalents/g). The highest antioxidant ability was observed with the aqueous extract of cashew (A. occidentale). Anti‐enzymatic activities such as acetylcholinesterase, butyrylcholinesterase and tyrosinase inhibition were most pronounced in A. occidentale (2.35 ± 0.02 mg galanthamine equivalent/g, 3.77 ± 0.01 mg galanthamine equivalent/g and 71.28 ± 0.07 mg kojic acid equivalent/g, respectively). The most toxic aqueous extract for H. armigera larvae was that of cashew with a lethal concentration LC50 = 11.68%. Moreover, the principal component analysis performed showed that the insecticidal activity is strongly correlated with the antioxidant and enzymatic activities of the aqueous extracts. Then, the hierarchical ascending classification showed cashew as the best plant. For the sustainability of cotton production, it would be necessary to limit the use of chemical‐synthetic insecticides through the use of plant extracts, especially from cashew leaves.

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Section: Discussionmentioning

confidence: 99%

Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast

Bini

Kobenan

Kouakou

et al. 2023

Arch Insect Biochem Physiol

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“…An earlier study by Abdullah Thaidi et al [1] had reported a positive inhibition effect on α-amylase and DPP-4 enzymes by using the crude extract of A. occidentale shoots, and had been analysed using high performance liquid chromatography (HPLC) to contain phenolic acids and flavonoids compounds which were gallic acid, ferulic acid, quercetin, kaempferol and p-coumaric acid. Besides, other studies had also mentioned the presence of polyphenol compounds in the A. occidentale which are caffeic acid, salicylic acid, sinapic acid, catechin, genistein, robustaflavone, myricetin, apigenin, vanillic acid and protocatechuic acid [1,4,[8][9][25][26][27]. Thus, a total of 15 polyphenols from A. occidentale namely caffeic acid, salicylic acid, sinapic acid, catechin, genistein, robustaflavone, kaemferol, quercetin, myricetin, apigenin, vanillic acid, gallic acid, ferulic acid, protocatechuic acid and ρ-coumaric acid were selected to conduct this current study and predict for future reference.…”

Section: Ligand Preparationmentioning

confidence: 99%

Molecular Docking of Polyphenol Compounds from Anacardium occidentale with Alpha-Glucosidase and Dipeptidyl-Peptidase-4 Enzymes

Farahin

Nadia

Susanti

et al. 2021

Mal. J. Fund. Appl. Sci.

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Type 2 diabetes mellitus (T2DM) is a chronic disease, in which the body failed to regulate blood glucose level due to insulin resistance. This condition may lead to high glucose level, which could potentially causes many serious health problems associated with cardiovascular system, nerve, eye and kidney. In treatment of T2DM, enzymes such as alpha-glucosidase (AG) and dipeptidyl-peptidase IV (DPP-4) have become the main targets since these enzymes play important roles in controlling the blood glucose level in the human body. In this study, the computational approach using molecular docking simulation study was used to predict the interaction and binding affinity of polyphenol compounds from Anacardium occidentale (A. occidentale) towards the AG and DPP-4 enzymes. The results were analysed based on three parameters: binding energy value, hydrogen bond formation and hydrophobic interaction between the compound and the protein at the binding site. The result showed that myricetin interacted with AG with the lowest binding energy of -7.6 kcal/mol and formed only one hydrogen bond to the Asp327 residue. In contrast, acarbose the positive control, interacted with many residues such as Asp327, Asp443 and Asp542 with the binding energy of - 6.0 kcal/mol. As for DPP-4 enzyme, sitagliptin was predicted as the best binder out of 15 polyphenols with binding energy of -9.2 kcal/mol. At the DPP-4 enzyme druggable region, sitagliptin formed an interaction with Tyr547 residue. In conclusion, our result suggested alpha-glucosidase as the most promising enzyme interacted with polyphenol compounds with favourable inhibitory effect since it can interact better than the current anti-diabetic drug, acarbose.

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“…Many scholars reviewed the health benefits of cashew and reported that almost all parts of the plant and their constituent are used as a curative against various human diseases such as a toothache, ringworm, coughs, colds, syphilis, stomach-ache, fever, cholera, kidney troubles, diarrhea, asthma, leprosy, elephantiasis, psoriasis, warts, corns fresh wounds and cuts (Aracelli et al, 2016;Judge and Azam-Ali, 2001;Runjala and Kella, 2017). Anacardic acids supplementation has a potential protective role on oxidative and inflammatory mechanisms in the lungs (Carvalho et al, 2013).…”

Section: Health Benefitsmentioning

confidence: 99%

Cashew production benefits and opportunities in Ethiopia: A Review

Tola¹,

Mazengia²

2019

J. Agric. Crop Res

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Cashew (Anacardium occidentale L.) is among the major edible nuts with increasing demand in the global market. The tree is native to Brazil and first introduced to India and Africa in the 16 th century by Portuguese traders with the intention of afforestation and soil conservation, and gradually expanded throughout the world. Today, it has been widely grown mainly for its nuts to be used as food, medicine, and source of income in most tropical regions with the largest coverage found in Brazil, India, Vietnam, Indonesia, and several countries in West and East Africa. The increasing demand for raw cashew nut from processors has made the crop to be the major source of foreign exchange in most developing countries. However, despite the huge potential to produce Cashew in Ethiopia, only little is known about its current production, potential benefits, and opportunities in Ethiopia, mainly due to lack of knowledge and awareness. Hence, this paper provides an overview of cashew uses, available opportunities for its production in Ethiopia and the way forward.

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Pharmacological properties of cashew (Anacardium occidentale)

Cited by 33 publications

References 102 publications

Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast

Phytochemical profiling, antioxidant activities, enzymatic activities and insecticidal potential of aqueous extracts of four plants on the larvae of Helicoverpa armigera (Lepidoptera: Noctuidae), the main pest of cotton plant in Ivory Coast

Molecular Docking of Polyphenol Compounds from Anacardium occidentale with Alpha-Glucosidase and Dipeptidyl-Peptidase-4 Enzymes

Cashew production benefits and opportunities in Ethiopia: A Review

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