“…Many studies combine the use of behavioral measures such as testing of the optomotor reflex to obtain visual acuity and contrast sensitivity data with physiological readouts such as electroretinography or structural assays such as OCT to obtain a more comprehensive overall assessment of retinal and neuronal health of a given subject. These methods have been employed in combination to assess visual differences amongst mouse strains (Puk et al, 2008), visual deficits in zebrafish models (Allwardt et al, 2001; Bahadori et al, 2006; Biehlmaier et al, 2007; Bilotta et al, 2002; Brockerhoff, 2006; Brockerhoff et al, 1995; Kainz et al, 2003; Le et al, 2012; Stujenske et al, 2011; Van Epps et al, 2001), therapeutic effects of compounds in goldfish (Mora-Ferrer et al, 2005), normal retinal function (Ho et al, 2012), therapies in visually impaired mice (Boye et al, 2010) and rats (McGill et al, 2007). The correlation of these parameters with morphological changes in the retina (McGill et al, 2012a; McGill et al, 2012b), was used to assess changes during retinal degeneration (Barabas et al, 2013; Cammas et al, 2010; Pang et al, 2011; Samardzija et al, 2014; Wright et al, 2013) and dysfunction (Hoelter et al, 2008; Lodha et al, 2010), eye blast trauma (Bricker-Anthony et al, 2014), visual deficits in diabetes mouse (Aung et al, 2013; Aung et al, 2014) and rat models, after transgenic modification of RGCs (Tomita et al, 2010) or bipolar cells (Lagali et al, 2008) or after transplanting photoreceptors in the retina to improve vision (Schmucker and Schaeffel, 2006; Thompson et al, 2014).…”