Pharmacological regulation of descending cortical control of the nociceptive processing

Харкевич, Д. А.; Churukanov, V.V.

doi:10.1016/s0014-2999(99)00264-2

Cited by 24 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the association between serotoninemia and pain threshold was also found in subjects with temporomandibular joint pain [16][17][18]. These findings fall within research on the key role of the serotoninergic system in the descending cortical control of nociceptive processing [19].…”

Section: Discussionmentioning

confidence: 72%

Pain reactivity in children with autistic disorder

Militerni¹,

Bravaccio²,

Falco³

et al. 2000

J Headache Pain

View full text Add to dashboard Cite

Abnormal pain reactivity is often reported by the parents of children with autistic disorder (AD). This is an interesting feature because it could be related to some neurochemical findings frequently reported in autism. The aim of the present study is to report the preliminary findings about pain reactivity in children with autism, and to relate them to serotoninemia. We studied 77 subjects with “primary” AD. Reports of each child's pain reactivity were obtained through a structured interview with the child's parent. In 44 of the 77 children, serotonin blood levels were measured. We found an abnormal pain reactivity in children with autistic disorder when compared with non-autistic children, matched for age, sex, and socio-economic level. The pain reactivity showed a significant correlation with the serotoninemia levels. The data obtained by the present study are interesting, although they must be considered with careful attention, both for the sample size and for methodological difficulties. In fact, in studying this disorder, only the parents' insight can be of help

show abstract

Section: Discussionmentioning

confidence: 72%

Pain reactivity in children with autistic disorder

Militerni¹,

Bravaccio²,

Falco³

et al. 2000

J Headache Pain

View full text Add to dashboard Cite

show abstract

“…Finally, clinical observation and experimental data provide evidence that the cerebral cortex is involved in the brain endogenous antinociceptive system [28][29][30], exerting an inhibitory descending control of nociception affected mainly by the serotonergic system. Our data confirm the importance of the cerebral cortex in the antinociceptive effect of ASA and the increase in serotonergic activity in this area as a possible mechanism of the action of this drug.…”

Section: Discussionmentioning

confidence: 98%

Central Antinociceptive Activity of Acetylsalicylic Acid Is Modulated by Brain Serotonin Receptor Subtypes

Sandrini¹,

Vitale²,

Pini

2002

Pharmacology

View full text Add to dashboard Cite

Male Wistar rats were treated with ondansetron (1 and 2 mg/kg s.c.), ketanserin (0.2, 1 and 5 mg/kg s.c.) or NAN-190 (1, 3 and 5 mg/kg i.p.) 15 min before acetylsalicylic acid (ASA, 400 mg/kg i.p.), and 30 min thereafter the pain threshold was evaluated. The antinociceptive activity of ASA in the hot-plate test was variously affected by ondansetron, ketanserin and NAN-190: at the highest dose (2 mg/kg s.c.) ondansetron abolished it while ketanserin (5 mg/kg s.c.) significantly reduced it, and NAN-190 (1–5 mg/kg) did not significantly modify the effect of ASA. Binding experiments indicate that both ondansetron and ketanserin completely prevented the decrease in the maximum number of 5-HT₂ receptors (B_max) provoked by ASA. These data indicate that the central antinociceptive activity of ASA is modulated in a different manner by serotonin receptor antagonists, and that 5-HT₂ and 5-HT₃ receptors may exert a pivotal role in nociception, alone or in association.

show abstract

“…Clinical and experimental data indicate that CC is important for functioning of the endogenous anti-nociceptive system. 39 Further, 5-HT2 receptors are predominantly located supraspinally and concentrated in the dorsal raphe nucleus and in the frontal cortex. 40 In the present study, significant increases in all parameters, except HIAA which showed decrease have been noticed in CC.…”

Section: Discussionmentioning

confidence: 99%

Alterations in aminergic system of rat brain by the opioid analgesic tramadol in the absence of pain-induction

Panadanabiona

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: Tramadol is an opioid analgesic used for treating moderate to severe pain. No research is available on pharmacology of tramadol without induction of pain. This study examines the effect of administration of tramadol on the levels of biogenic amines and their metabolites in the brain areas of male adult Wistar rats, without inducing pain. Methods: Tramadol was injected subcutaneously at 0, 24, and 48 hours, and changes in the levels of epinephrine (EP), norepinephrine (NE), dopamine (DA) and serotonin (5-HT), 5-hydroxyindoleacetic acid (HIAA) and homovanillic acid (HVA) were examined in cerebral cortex, cerebellum, pons-medulla, hippocampus and thalamus. The changes were recorded in the select brain areas at 3, 6, 12, 24 hours after the first injection, as well as at 24 hours after the second and third injections, respectively. Results: Administration of tramadol at 0 hours elevated the levels of DA, 5-HT and HVA in all brain areas. Changes in levels of EP, NE, and HIAA varied across the four brain areas surveyed. All parameters showed maximal changes at 3 or 6 hours following the first administration at 0 hours. For the second and third doses of tramadol at 24 and 48 hours respectively, the parameters showed variations at 48 and 72 hours that generally fluctuated around the control. Conclusions:The results indicate differential tissue responses to administered tramadol in different areas of the brain. The results suggest that the alterations in biogenic amines for the administration of tramadol are similar under both pain and no-pain conditions.

show abstract

Pharmacological regulation of descending cortical control of the nociceptive processing

Cited by 24 publications

References 27 publications

Pain reactivity in children with autistic disorder

Pain reactivity in children with autistic disorder

Central Antinociceptive Activity of Acetylsalicylic Acid Is Modulated by Brain Serotonin Receptor Subtypes

Alterations in aminergic system of rat brain by the opioid analgesic tramadol in the absence of pain-induction

Contact Info

Product

Resources

About