Pharmacological Role of <i>Ostericum koreanum</i>: A Short Viewpoint

Nasab, Narges Hosseini; Shah, Fahad Hassan; Kim, Song Ja

doi:10.1177/1934578x211050790

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The removal of the acetyl group increased the polarity of the compound, making it less soluble in commonly used solvents such as ethyl acetate and dichloromethane. The Considering the increasing interest in natural products as potential sources of novel drugs [24] or as lead structures for drug discovery in medicinal and organic chemistry [25,26], and drawing inspiration from existing data [19] highlighting puniceloid D as the most potent LXRα agonist, our study presents the total synthesis of puniceloid D for the first time. Furthermore, significant results from molecular docking studies were obtained with puniceloid D.…”

Section: Total Synthesis Of Puniceloid Dmentioning

confidence: 99%

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Jung,

Hosseininasab,

Park

et al. 2024

Molecules

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A growing global health concern is metabolic syndrome, which is defined by low HDL, diabetes, hypertension, and abdominal obesity. Nuclear receptors are attractive targets for treatment of diseases associated with metabolic syndrome. Liver X receptors (LXRs) have become one of the most significant pharmacological targets among nuclear receptors. Multiple research studies emphasize the essential function of the liver X receptor (LXR) in the pathophysiology of metabolic syndrome. Puniceloid D, among natural products, demonstrated promising effects on LXRα. However, attempts at the total synthesis of natural products were faced with challenges, including long synthetic steps and low yields, requiring a more efficient approach. In this study, for the first time, we successfully synthesized puniceloid D through a seven-step process and conducted docking studies to gain a comprehensive understanding of the interactions involved in the binding of puniceloid D to LXR within different heterodimeric contexts. Our understanding of the pathophysiology of metabolic syndrome could be improved by these findings, which might assist with the development of novel treatment strategies.

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Section: Total Synthesis Of Puniceloid Dmentioning

confidence: 99%

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Jung,

Hosseininasab,

Park

et al. 2024

Molecules

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“…The plant material used in this study, called Ganghwal in Korea, is one of the most important perennials native to Asian countries belonging to the family Umbelliferae [6]. In the Korean Pharmacopoeia, the origin of Ganghwal is defined as the root of Ostericum koreanum Maxim., or the rhizome and root of Notopterygium incisum Ting or Notopterygium forbesii Boissier (Umbelliferae).…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

et al. 2023

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The aim of this study was to discover bioactive constituents of Angelica reflexa that improve glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells. Herein, three new compounds, namely, koseonolin A (1), koseonolin B (2), and isohydroxylomatin (3), along with 28 compounds (4–31) were isolated from the roots of A. reflexa by chromatographic methods. The chemical structures of new compounds (1–3) were elucidated through spectroscopic/spectrometric methods such as NMR and HRESIMS. In particular, the absolute configuration of the new compounds (1 and 3) was performed by electronic circular dichroism (ECD) studies. The effects of the root extract of A. reflexa (KH2E) and isolated compounds (1–31) on GSIS were detected by GSIS assay, ADP/ATP ratio assay, and Western blot assay. We observed that KH2E enhanced GSIS. Among the compounds 1–31, isohydroxylomatin (3), (−)-marmesin (17), and marmesinin (19) increased GSIS. In particular, marmesinin (19) was the most effective; this effect was superior to treatment with gliclazide. GSI values were: 13.21 ± 0.12 and 7.02 ± 0.32 for marmesinin (19) and gliclazide at a same concentration of 10 μM, respectively. Gliclazide is often performed in patients with type 2 diabetes (T2D). KH2E and marmesinin (19) enhanced the protein expressions associated with pancreatic β-cell metabolism such as peroxisome proliferator-activated receptor γ, pancreatic and duodenal homeobox 1, and insulin receptor substrate-2. The effect of marmesinin (19) on GSIS was improved by an L-type Ca2+ channel agonist and K+ channel blocker and was inhibited by an L-type Ca2+ channel blocker and K+ channel activator. Marmesinin (19) may improve hyperglycemia by enhancing GSIS in pancreatic β-cells. Thus, marmesinin (19) may have potential use in developing novel anti-T2D therapy. These findings promote the potential application of marmesinin (19) toward the management of hyperglycemia in T2D.

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Effects of the administration of Shinbaro 2 in a rat lumbar disk herniation model

Kim

Shin²,

Lee³

et al. 2023

Front. Neurol.

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The current standard for the pharmacological management of lumbar disk herniation (LDH), involving non-steroidal anti-inflammatory drugs, muscle relaxants, and opioid analgesics, often carries a risk of adverse events. The search for alternative therapeutic options remains a vital objective, given the high prevalence of LDH and the critical impact on the quality of life. Shinbaro 2 is a clinically effective herbal acupuncture against inflammation and various musculoskeletal disorders. Therefore, we explored whether Shinbaro 2 exerts protective effects in an LDH rat model. The results showed that Shinbaro 2 suppressed pro-inflammatory cytokines, interleukin-1 beta, tumor necrosis factor-alpha, disk degeneration-related factors, matrix metalloproteinase-1,−3,−9, and ADAMTS-5 in LDH rats. Shinbaro 2 administration reinstated a behavioral activity to a normal level in the windmill test. The results indicated that Shinbaro 2 administration restored spinal cord morphology and functions in the LDH model. Therefore, Shinbaro 2 exerted a protective effect in LDH via actions on inflammatory responses and disk degeneration, indicating that future research is warranted to assess the action mechanisms further and validate its effects.

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Pharmacological Role of Ostericum koreanum: A Short Viewpoint

Cited by 3 publications

References 31 publications

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Microwave-Promoted Total Synthesis of Puniceloid D for Modulating the Liver X Receptor

Chemical Constituents from the Roots of Angelica reflexa That Improve Glucose-Stimulated Insulin Secretion by Regulating Pancreatic β-Cell Metabolism

Effects of the administration of Shinbaro 2 in a rat lumbar disk herniation model

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