Pharmacological Studies of Novel Marine Metabolites

Jacobs, Robert S.; Bober, Mary A.; Pinto, Isabel; Williams, Allen B.; Jacobson, Peer B.; Carvalho, M. S. de

doi:10.1007/978-1-4899-2391-2_3

Cited by 12 publications

(9 citation statements)

References 39 publications

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“…Furthermore, G. rufomarginata from China presents scalarane compounds derived from feeding on an unidentified sponge, which are biotransformed into scalaradial derivatives. In particular, scalaradial, a potent anti-inflammatory metabolite [253], and its 12-deacetyl derivative are present in the sponge, while the absence of scalaradial in the slug supports their ability to transform this toxic compound into related scalaranes [254]. Similarly, G. pallida specimens from China, as well as G. vespa and G. averni from Australia, contain 12-deacetoxy-12-oxoscalaradial [255], while G. pallida from Guam presents different sesquiterpenes including scalaradial, deacetylscalaradial, and deoxoscalarin; these compounds are used as feeding deterrents against sympatric crabs and reef fish and are located in the mantle border of the slugs [256,257].…”

Section: Tetracyclic Sesterterpenoidsmentioning

confidence: 99%

Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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Heterobranch molluscs are rich in natural products. As other marine organisms, these gastropods are still quite unexplored, but they provide a stunning arsenal of compounds with interesting activities. Among their natural products, terpenoids are particularly abundant and diverse, including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids, tetraterpenoids, and steroids. This review evaluates the different kinds of terpenoids found in heterobranchs and reports on their bioactivity. It includes more than 330 metabolites isolated from ca. 70 species of heterobranchs. The monoterpenoids reported may be linear or monocyclic, while sesquiterpenoids may include linear, monocyclic, bicyclic, or tricyclic molecules. Diterpenoids in heterobranchs may include linear, monocyclic, bicyclic, tricyclic, or tetracyclic compounds. Sesterterpenoids, instead, are linear, bicyclic, or tetracyclic. Triterpenoids, tetraterpenoids, and steroids are not as abundant as the previously mentioned types. Within heterobranch molluscs, no terpenoids have been described in this period in tylodinoideans, cephalaspideans, or pteropods, and most terpenoids have been found in nudibranchs, anaspideans, and sacoglossans, with very few compounds in pleurobranchoideans and pulmonates. Monoterpenoids are present mostly in anaspidea, and less abundant in sacoglossa. Nudibranchs are especially rich in sesquiterpenes, which are also present in anaspidea, and in less numbers in sacoglossa and pulmonata. Diterpenoids are also very abundant in nudibranchs, present also in anaspidea, and scarce in pleurobranchoidea, sacoglossa, and pulmonata. Sesterterpenoids are only found in nudibranchia, while triterpenoids, carotenoids, and steroids are only reported for nudibranchia, pleurobranchoidea, and anaspidea. Many of these compounds are obtained from their diet, while others are biotransformed, or de novo biosynthesized by the molluscs. Overall, a huge variety of structures is found, indicating that chemodiversity correlates to the amazing biodiversity of this fascinating group of molluscs.

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Section: Tetracyclic Sesterterpenoidsmentioning

confidence: 99%

Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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“…As reported above, several species of Glossodoris present scalaradial ( 44 ) and other scalarane compounds derived from the sponges they feed on [ 22 , 166 , 175 , 180 , 381 , 383 , 856 ]. These include Glossodoris rufomarginata , G. pallida , G. vespa , G. averni , G. hikuerensis , G. atromarginata , and G. cincta from different geographical locations [ 22 , 166 , 175 , 178 , 380 , 381 , 383 , 536 , 856 ].…”

Section: Pharmacological Activitymentioning

confidence: 99%

Bioactive Compounds from Marine Heterobranchs

Ávila

Angulo‐Preckler

2020

Marine Drugs

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The natural products of heterobranch molluscs display a huge variability both in structure and in their bioactivity. Despite the considerable lack of information, it can be observed from the recent literature that this group of animals possesses an astonishing arsenal of molecules from different origins that provide the molluscs with potent chemicals that are ecologically and pharmacologically relevant. In this review, we analyze the bioactivity of more than 450 compounds from ca. 400 species of heterobranch molluscs that are useful for the snails to protect themselves in different ways and/or that may be useful to us because of their pharmacological activities. Their ecological activities include predator avoidance, toxicity, antimicrobials, antifouling, trail-following and alarm pheromones, sunscreens and UV protection, tissue regeneration, and others. The most studied ecological activity is predation avoidance, followed by toxicity. Their pharmacological activities consist of cytotoxicity and antitumoral activity; antibiotic, antiparasitic, antiviral, and anti-inflammatory activity; and activity against neurodegenerative diseases and others. The most studied pharmacological activities are cytotoxicity and anticancer activities, followed by antibiotic activity. Overall, it can be observed that heterobranch molluscs are extremely interesting in regard to the study of marine natural products in terms of both chemical ecology and biotechnology studies, providing many leads for further detailed research in these fields in the near future.

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“…They are also known as poly unsaturated fatty acids [66] [67]. Among them, eicosanoid and its derivatives are received much more attention in research because of its anti-inflammatory properties [68]. www.ijsrp.org…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Brief Overview of Bioactive Compounds in Seaweeds, Their Properties and Practical Applications in Functional Foods

Kothalawala¹,

Chathurangi²,

Yatiwella³

2018

IJSRP

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Seaweeds are a rich source of bioactive compounds as discovered by many research studies in recent history. Even though there are numerous methods to generate certain bioactive compounds from chemical modifications, advantages of extracting them from natural seaweeds have exceeded the artificial synthesis. However, practical applications of seaweeds are mainly observed to pharmaceutical industry, drug development and functional foods so far. This is due to the bioactive properties such as antiviral, antitumor, anticancer, anti-inflammatory and antilipidemic beneficial for such industries. Functional food market has also indicated a steady growth due to the health-conscious consumption pattern of the people creating even more demand on seaweeds. Most of the countries surrounded by coastal regions have indicated a growth of research on seaweeds in order to utilize them as biofuel. Idea behind this review is to provide a brief but a comprehensive understanding of metabolites, bioactive properties and applications of seaweeds.

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Pharmacological Studies of Novel Marine Metabolites

Cited by 12 publications

References 39 publications

Terpenoids in Marine Heterobranch Molluscs

Terpenoids in Marine Heterobranch Molluscs

Bioactive Compounds from Marine Heterobranchs

Brief Overview of Bioactive Compounds in Seaweeds, Their Properties and Practical Applications in Functional Foods

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