Pharmacological studies of pulmonary anaphylaxisin vitro: A review

Ogunbiyi, P. O.; Eyre, P.

doi:10.1007/bf01966586

Cited by 12 publications

(6 citation statements)

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“…In other studies (Norris & Eyre, 1982;Perron, 1982) there were indications that mast cell padrenergic receptors were impaired by the virus or products of virus-tissue interactions. The role of histamine in bovine pulmonary anaphylaxis is controversial (Eyre, 197 1;Ogunbiyi & Eyre, 1985). It may be of minor importance in hypersensitivity or inflammation of a non-infectious nature.…”

Section: Discussionmentioning

confidence: 99%

“…However, it had no significant effect on the increase in ionophore-induced release of histamine in these calves. Its inhibition of spontaneous histamine release in virus-infected calves may be due to its influence on cellular cyclic nucleotide levels which are known to modulate mast cell mediator release (Symoens et al, 1980;Ogunbiyi et al, 1985). Its ineffectiveness on ionophore-induced release in these calves probably reflects the high efficacy of the calcium ionophore at 5 x M and indi-…”

Section: Discussionmentioning

confidence: 99%

“…Published reports on histamine releasing activities in cattle have employed lung fragments and blood basophils (Eyre, 1971;Holroyde & Eyre, 1978;Perron & Eyre, 1982). However, due to the shortcomings of the chopped lung model (Ogunbiyi & Eyre, 1985), dispersed lung mast cells were used in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Parainfluenza‐3 virus‐induced enhancement of histamine release from calf lung mast cells – effect of levamisole

Ogunbiyi

Black

Eyre

1988

Vet Pharm & Therapeutics

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Clinically healthy calves were divided into five groups. Group 1 served as control; Group 2 received levamisole (LEV), 3 mg/kg, s.c.; Group 3 was aerosolized with parainfluenza-3 virus (PI-3); Group 4 received LEV and PI-3 and Group 5 was inoculated with Pasteurella haemolytica. They were killed 6 days after virus exposure or 5-6 days after bacterial inoculation. Lung mast cells were prepared by enzymatic treatment. Mast cell histamine (HIST) release was assayed spectrofluorometrically. Total HIST (micrograms/g) in mast cells was as follows (means +/- SEM): control (5.30 +/- 0.26); LEV (5.27 +/- 0.31); PI-3 (6.37 +/- 0.65); LEV + PI-3 (6.21 +/- 0.51); P. haemolytica (7.06 +/- 0.85). Spontaneous HIST release was as follows (% total, means +/- SEM): control (10.38 +/- 1.09), LEV (11.95 +/- 2.13), PI-3v (73.57 +/- 11.97), PI-3v + LEV (19.50 +/- 3.03), and P. haemolytica (70.59 +/- 5.94). Calcium ionophore A23187 (5 X 10(-6) M)-induced release (% total, means +/- SEM) was: 51.53 +/- 3.05, 50.02 +/- 2.70, 83.91 +/- 4.09, 75.21 +/- 4.51 and 70.59 +/- 6.91 for control, LEV, PI-3, LEV + PI-3 and P. haemolytica groups, respectively. Both virus and bacteria increased HIST content of lung mast cells and enhanced ionophore-induced release. Levamisole significantly reduced spontaneous HIST release in virus-infected calves but had no effect on ionophore-induced release. Results suggest a significant role for HIST in pathogenesis of bovine microbial pneumonia and that LEV probably does not modulate non-immunologic release of HIST from bovine lungs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Parainfluenza‐3 virus‐induced enhancement of histamine release from calf lung mast cells – effect of levamisole

Ogunbiyi

Black

Eyre

1988

Vet Pharm & Therapeutics

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“…The pathological features of type I hypersensitivity reactions in the lung result from the combined actions of pre-formed mediators and newly formed lipid products released from sensitized cells as a consequence of the interaction between reaginic antibody and antigen (Kagey-Sobotka et al, 1982;Ogunbiye & Eyre, 1985). During anaphylaxis in animal and human lung in vitro, histamine and a number of metabolites of arachidonic acid such as prostaglandins, thromboxanes and leukotrienes are released (Piper & Vane, 1969;Schulman et al, 1981).…”

Section: Introductionmentioning

confidence: 99%

Release of arachidonic acid metabolites and histamine from sensitized guinea‐pig lung following antigen challenge

Turner

Dollery

1988

British J Pharmacology

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1 The time course of mediator release and the hypothesis that the ratio of eicosanoids to histamine might alter with the intensity of stimulus or its route of administration has been explored in isolated perfused lung from sensitized guinea-pigs challenged with ovalbumin. 2 Histamine and prostaglandin release was rapid in onset and virtually complete within 10min. Thromboxane B2 (TXB2) and leukotriene D4 (LTD4) release, however, was more sustained. Release of the major prostanoid metabolites was relatively delayed compared to that of the parent compounds and was more sustained. 3 Mediator release was antigen-dose dependent and TXB2, prostaglandin D2 (PGD2) and LTD4 release linearly related to histamine concentrations (P < 0.05). However, the ratio of the percentage maximum release of eicosanoids relative to histamine was greatest with low doses of ovalbumin.4 At a low antigen dose (10yg ovalbumin), histamine and prostanoid release was greatest when the challenge was via the airway rather than into the pulmonary artery and the greatest differences were in PGF2,, levels. At near maximal challenge (1 mg ovalbumin) there was little difference in concentrations of PGD2, TXB2, 6-oxo-PGFI. and LTD4 by either route, but PGF2. levels remained greater. 5 The results indicate that biologically active amounts of prostanoids may be released from sensitized lung at low degrees of mast cell activation and that differences in mediator release following antigen administration to the airway or into the pulmonary vasculature simply reflects its accessibility to sensitized cells.

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“…Tıbbi Farmakoloji tissues such as contraction of smooth muscles, dilation and increase in the permeability of vascular system, stimulation of exocrine glands and vagal stimulation. 25 In a stduy, challenge of the sensitized trachea with an antigen resulted with a product of the epithelium dependent relaxing factor(s) (EpDRF(s) and not the cyclooxygenase or lipoxygenase pathways. 26 This contention was supported by some investigators as well.…”

Section: 11mentioning

confidence: 99%

Effects of 5-Lipoxygenase Inhibitors on Guinea Pig Trachea in Ovalbumin-Induced Experimental Asthma

Gürel¹,

Timlioğlu²

2012

Turkiye Klinikleri J Med Sci

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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The 5-lipoxygenase products, especially sulfidopeptide leukotrienes take an important role in the pathogenesis of asthma. The effects of two selective 5-lipoxygenase inhibitors, acetohydroxamic acid derivative BWA 4C and a naphtokinon derivative CGS 8515, were investigated for their effect on antigen-induced contraction in ovalbumin sensitized guinea-pig isolated tracheal tissues. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study included 15 male guinea pigs. They were actively sensitized by the Modified Andersson Method, including two standard 0.5 mL injections of a solution containing 20 µg ovalbumin and 50 mg aluminium hydroxide in saline on day 0 and day 14. Twenty-one to 27 days after the injection of ovalbumin, the tracheal rings from sensitized guinea pigs were exposed to antigen, and the possible inhibitor effects of 5-lipoxygenase inhibitors on the antigen-induced contraction were examined in water-jacketed tissue baths containing Krebs buffer. R Re es su ul lt ts s: : Both BWA 4C and CGS 8515 significantly reduced antigen-induced tracheal contraction compared to control groups. C Co on nc cl lu us si io on n: : As both CGS 8515 and BWA 4C inhibit antigen induced tracheal smooth muscle contractions, they may take an important role in the treatment of asthma and related inflammatory events.

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Pharmacological studies of pulmonary anaphylaxisin vitro: A review

Cited by 12 publications

References 144 publications

Parainfluenza‐3 virus‐induced enhancement of histamine release from calf lung mast cells – effect of levamisole

Parainfluenza‐3 virus‐induced enhancement of histamine release from calf lung mast cells – effect of levamisole

Release of arachidonic acid metabolites and histamine from sensitized guinea‐pig lung following antigen challenge

Effects of 5-Lipoxygenase Inhibitors on Guinea Pig Trachea in Ovalbumin-Induced Experimental Asthma

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