Pharmacological studies of the uninhibited neurogenic bladder

Jensen, Ditlev

doi:10.1111/j.1600-0404.1981.tb04398.x

Cited by 41 publications

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References 20 publications

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“…To my knowledge, there has so far been no systematic comparative study of the effects on uninhibited and on normal human bladder obtained by stimulation and inhibition of the adrenergic system. Preliminary reports (Jensen 1977(Jensen , 1981d) and a supplementary discussion (Jensen 1981e) have been published. MATERIAL The results presented are based on studies performed on 82 adult patients (39 females and 43 males): 39 with normal neurourological findings (mean age 52, range 21-82 years), and 43 with uninhibited neurogenic bladder (mean age 55, range 24-80 years).…”

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Pharmacological studies of the uninhibited neurogenic bladder

Jensen

2009

Acta Neurologica Scandinavica

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In order to elucidate the sympathetic activity of the uninhibited neurogenic bladder, controlled cystometry before and during the influence of alpha‐ and beta‐adrenergic agonists and antagonists was performed on patients with normal and uninhibited neurogenic bladder. Alpha‐agonist increased the pathological findings in the cystometrogram of the uninhibited bladder with increase in intravesical pressure, decrease in capacity and increase in the amplitude of the uninhibited contraction, but had no effect whatsoever on the normal bladder. Alpha‐antagonists improved the uninhibited bladder with decrease in intravesical pressure, increase in capacity and decrease in amplitude of the uninhibited contraction, and decrease in intravesical pressure in normal bladder. Beta2‐agonist improved the uninhibited bladder too, but was proved to be inactive on the normal bladder. Unselective beta‐ and selective beta1 antagonists deteriorated the uninhibited bladder and had only minor effect on the normal bladder. The decreased capacity and forcible uninhibited detrusor contraction seem to be due to a reduction of inhibitory beta‐adrenergic impulses as well as an increased contractile alpha‐adrenergic action on the bladder wall in uninhibited neurogenic bladder.

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confidence: 99%