Pharmacological Studies on Bupleurum falcatum L. IV. Some Pharmacological Effects of Crude Saikosides, Saikogenin A and Syrupy Residue

Shibata, Madoka; Yoshida, Ryuji; Motoashi, S; Fukushima, M

doi:10.1248/yakushi1947.93.12_1660

Cited by 18 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The roots of B. falcatum have been used clinically in Chinese and Japanese herbal medicine (kampo medicine). Shibata et al [42] have reported that a crude saponin fraction of B. falcatum showed weak antiulcerogenic activity in pylorus ligated ulcer model. Yamada et al [43] found that the polysaccharide fraction of B. falcatum possesses potent antiulcer activity against HCl/ethanolinduced lesions in mice.…”

Section: Bupleurum Falcatum Bmentioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

View full text Add to dashboard Cite

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used therapeutic drug groups used worldwide for curing an array of health problems like pain, inflammation, cardiovascular complications, and many other diseases, but they may cause different side effects including gastroduodenal disorders. So, there is a growing interest and need to search for nontoxic, antiulcer formulations from medicinal plants to treat NSAIDs induced gastric ulcer. Extensive research has reported on many natural plants like Camellia sinensis, Phyllanthus emblica, Myristica malabarica, Piper betle, Picrorhiza kurroa, and so forth, and their active constituents reduced NSAIDs induced gastric ulcer via their antioxidative as well as immunomodulatory activity. Therefore, use of herbal formulations in daily life may prevent NSAIDs induced gastric ulceration and other side effects.

show abstract

Section: Bupleurum Falcatum Bmentioning

confidence: 99%

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Chatterjee

Bandyopadhyay

2014

Ulcers

View full text Add to dashboard Cite

show abstract

“…The roots of Bupleurumfalcatum falcatum (a species of flowering plant in the Apiaceae family) have shown weak antiulcerogenic activity in pylorus ligated ulcer model (Shibata et al, 1973). Also, the polysaccharide fraction of B. falcatum possesses potent antiulcer activity against HCl/ethanol-induced lesions in mice (Yamada et al, 1989).…”

Section: Nutraceutical-based Treatment Options For Peptic Ulcersmentioning

confidence: 99%

Nutraceuticals in Gastrointestinal Disorders

Banerjee¹,

Giri²

2016

Nutraceuticals

View full text Add to dashboard Cite

“…Bupleurum falcatum is one of the most widely used components in traditional oriental medicines. B. falcatum, or its important principle saikosaponins, is known to have numerous pharmacological activities, including antiinflammatory (Takai and Shibata, 1969;Zhou et al, 1983), antipyretic (Shibata et al, 1973) and antitussive (Huang, 1993) actions. From a preliminary study with a series of plant extracts we observed that the methylene chloride fraction of B. falcatum root possesses antiallergic activity.…”

Section: Introductionmentioning

confidence: 99%

Effect of saikosaponin‐A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma

Park

Koh

et al. 2002

Phytotherapy Research

View full text Add to dashboard Cite

The separation and isolation of an extract of Bupleurum falcatum were performed based on antiallergic activities in preliminary studies with higher plants. The final active compound was identified as saikosaponin-A (SSA), a triterpenoid glycoside. SSA at more than 1 mg/kg (i.v.) significantly inhibited the passive cutaneous anaphylaxis reaction in rats in a dose-dependent manner, attaining a maximum inhibition of approximately 60% with 10 mg/kg. SSA at 3 and 10 mg/kg also suppressed asthmatic bronchoconstriction in sensitized guinea-pigs. SSA possesses a weak inhibitory activity on histamine-induced tracheal contraction in guinea-pigs and on histamine release induced by A-23187 in rat mast cells. These results indicate that SSA has an inhibitory activity against allergic asthma. This activity seems to derive from both antagonism of the histamine action and inhibition of allergic mediators. Additional mechanisms may also be involved.

show abstract

Pharmacological Studies on Bupleurum falcatum L. IV. Some Pharmacological Effects of Crude Saikosides, Saikogenin A and Syrupy Residue

Cited by 18 publications

References 0 publications

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Herbal Remedy: An Alternate Therapy of Nonsteroidal Anti-Inflammatory Drug Induced Gastric Ulcer Healing

Nutraceuticals in Gastrointestinal Disorders

Effect of saikosaponin‐A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma

Contact Info

Product

Resources

About