Pharmacological studies on Ephedra nebrodensis Tineo

Ballero, Mauro; Foddis, Caterina; Scartezzini, Paolo; Poli, Ferruccio; Serafini, Mara Serena; Stanzione, Alessandra; Petitto, Valentina; Bianco, A; Serrilli, Anna Maria; Spina, Liliana; Longoni, R; Kasture, S. B.

doi:10.1055/s-0028-1084176

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“…For both these reasons, the wide variety of secondary metabolites and their bioactivities, the studies about the phytochemistry of this species are currently in the limelight. In this article, we report the phytochemical analysis of a sample of D. oleoides collected from a spontaneous population growing in Sardinia Island to verify if the isolated environment may have favored the development of a peculiar secondary metabolites pattern, as we already evidenced in other species growing in restricted areas and, in particular, in Sardinian territory . In fact, Sardinia, according to ‘Conservation International’ is part of the ten ‘mini‐Hotspots’ recognizable in the Mediterranean basin.…”

Section: Introductionmentioning

confidence: 89%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8, and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses. The identification of these compounds gives an experimental evidence of the variability in the secondary metabolites pattern owned by populations growing in restricted area in respect to populations not confined by geographical barrier.

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Section: Introductionmentioning

confidence: 89%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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“…From the past one decade, herbal medicine would be a thrust area for finding their pharmacological and therapeutic values against DM. [10] Even, numerous plants and their extracts have been proved to be cardio and renal protective including Centella asiatica, [11] Ephedra nebrodensis, [12] Punica granatum, [13] Pomegranate, [14] and Lagenaria siceraria standley. [15,16] However, E. hirta (Euphorbiaceae), vernacularly called as Dudhi or Dudhanim, has unique combination of possible therapeutic action including antidiabetic, antioxidant, and antiobesity.…”

Section: Original Articlementioning

confidence: 99%

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Katare¹

2018

IJGP

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Introduction: Euphorbia hirta is a traditional medicine having unique combination of possible therapeutic action including antidiabetic, antioxidant, and antiobesity. The present study focuses to evaluate the therapeutic potency of ethanolic extract of E. hirta against diabetes mellitus (DM) and associated cardiorenal injury. Materials and Methods: DM was induced by administration of double cycle of repetitive (single injection for 3 alternative days in one cycle) dose of streptozotocin (20 mg/kg/i.p) in high-fat diet animals. Fasting and postprandial blood glucose level, glycated hemoglobin A1c (HbA1c), C-peptide, and plasma insulin were measured to confirm the induction of DM. Serum lipid profile and thiobarbituric acid reactive substances (TBARS) were measured in diabetic animals. Diabetic animals were further evaluated for cardiorenal toxicity after 12 weeks by measuring creatine kinase MB, lactate dehydrogenase, cardiac troponin I, serum creatinine, and blood urea nitrogen, respectively. Structural alteration was observed by histological assessments of pancreatic β-cells and cardiorenal tissues. Results: A significant increased level of fasting and postprandial blood glucose, and HbA1c and decreased level of C-peptide and plasma insulin were observed in diabetic animals. Furthermore, diabetic animals showed abnormal lipid profile (dyslipidemia) and increase serum TBARS (oxidative stress). In addition, the increased level of cardiorenal biomarkers in diabetic animals confirmed the associated abnormalities. The treatment of E. hirta (400 mg/kg/p.o) significantly overcomes the perturbed level of hyperglycemic, lipid profile, oxidative stress, and cardiorenal biomarkers. Histological evaluation of pancreatic and cardiorenal tissue also validates the significant protection of E. hirta against DM and-induced cardiorenal toxicity. Discussion and Conclusion: Thus, E. hirtainduced cardiorenal protection may associate with its antihyperglycemic, antidyslipidemia, and antioxidant potential.

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Pharmacological studies on Ephedra nebrodensis Tineo

Cited by 2 publications

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New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

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