Pharmacological Studies on Schizandra Fruits. II. Effects of Constituents of Shizandra Fruits on Drugs Induced Hepatic Damage in Rats

Maeda, Shinya; Sudo, Kazuhiko; Miyamoto, Yoshimasa; Takeda, Shogo; Shinbo, Masumi; Aburada, Masaki; Ikeya, Yukinobu; Taguchi, Heihachiro; Harada, Masatoshi

doi:10.1248/yakushi1947.102.6_579

Cited by 25 publications

(15 citation statements)

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“…4). Discussion TJN-101 shows an inhibitory effect on liver cell injuries induced by various hepato toxic chemicals (2)(3)(4)(5), and it also prevents liver injuries caused by immunological reac tions in vivo and in vitro (6,7). From these findings, it was thought that TJN-101 pro tects the liver cells from cytotoxicities.…”

Section: Effect On the Production Of Ltb4mentioning

confidence: 99%

“…Gomisin A (TJN-101), a lignan component of schisandra fruits (1), has been known to prevent liver injuries induced by hepatotoxic chemicals (2)(3)(4)(5). We have previously reported that TJN-101 reduced the mortality of mice with immunological acute hepatic failure ex perimentally induced by the injection of heat killed Propionibacterium aches (P. aches) and a small dose of lipopolysaccharide (6).…”

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confidence: 99%

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Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.

et al. 1990

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Abstract-It has been reported that leukotrienes (LTs) may play a role in inflam matory liver diseases, and several inhibitors of LTs show an inhibitory effect on experimental liver injuries. In this study, the effect of Gomisin A (TJN-101), which is a lignan component of schisandra fruits, on the arachidonic acid cascade in macrophages was examined to explain the mechanisms of the inhibitory effect of TJN-101 on liver injuries. The production of leukotriene B4 was suppressed by treatment with TJN-101, while the activity of 5-lipoxygenase was not affected. The release of arachidonic acid from macrophages stimulated with fMet-Leu-Phe or the Ca" lonophore A23187 was suppressed by treatment with TJN-101. The activity of phospholipase A2 was not affected by treatment with TJN-101. These results suggested that TJN-101 produces an inhibitory effect on the biosynthesis of LTs by preventing the release of arachidonic acid, and it was thought that the preventive effect on the arachidonic acid cascade may be partially associated with the inhibitory effect of TJN-101 on liver injuries.

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Section: Effect On the Production Of Ltb4mentioning

confidence: 99%

mentioning

confidence: 99%

Effect of Gomisin A (TJN-101) on the arachidonic acid cascade in macrophages.

et al. 1990

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“…GOMISHIN A 16) and UEIJISU C, 17) both of which are antioxidants, are known as the active substances of Schisandra chinensis Baillon for hepatoprotection in vivo. Glycyrrhiza glabra L. suppresses liver injury in vivo, [18][19][20] and its active substance is thought to be glycyrrhizin.…”

Section: Discussionmentioning

confidence: 99%

Small Scale Rat Hepatocyte Primary Culture with Applications for Screening Hepatoprotective Substances

Nakagiri¹,

Oda²,

Kamiya³

2003

Bioscience, Biotechnology, and Biochemistry

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“…These findings suggest that gomisin A may protect a lowered liver function in parenchymal injuries, and such preventive effects of gomisin A on hepatotoxicities may have partly resulted from the protective action on the hepatocytes . (1 ).…”

Section: Discussionmentioning

confidence: 99%