Pharmacological Studies on the Chinese Crude Drug"Shoma". III. Central Depressant and Antispasmodic Actions of Cimicifuga Rhizoma, Cimicifuga simplex WORMSK

Shibata, Madoka; Ikoma, Mio; Onoda, M.; Sato, F; Sakurai, Nobuko

doi:10.1248/yakushi1947.100.11_1143

Cited by 9 publications

(3 citation statements)

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“…However, in Washington and Oregon where this species is more abundant, research has focussed on pollination ecology (Pellmyr 1985a(Pellmyr , 1985b(Pellmyr , 1986, and on population genetic structure with implications associated with its rarity (Evans 1993). There have also been studies on the presence of active compounds of pharmacological use in species of Cimicifuga, particularly those in the Far East (Shibata et al 1980).…”

Section: Biologymentioning

confidence: 99%

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Status of the Tall Bugbane, Cimicifuga elata (Ranunculacae), in Canada

Penny,

Douglas

1999

The Canadian Field-Naturalist

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In British Columbia, Cimicifuga elata is restricted to eight recently verified sites in the Chilliwack River valley. Population sizes are relatively small, ranging from a single plant to 63 plants, making this species susceptible to low genetic diversity. Suitable habitat for C. elata in the Chilliwack River valley appears to be mature, mixed Cedar-Hemlock-Maple stands, Douglas-fir-Maple stands, and some deciduous stands. However, most of the range of this species has been extensively converted through logging to young forest. Young stands that develop following harvest do not contain suitable habitat to sustain C. elata, therefore, current forest harvest practises threaten this species. Cimicifuga elata has reproductive limitations that make colonization into new sites difficult. It is relatively much less attractive to pollinators than other flowering plants, and lacks any effective seed dispersal mechanism. Considering these biological limitations, the uncertainty of the effect of logging practices on this species, and the small population sizes, the future of C. e/ata is uncertain in the Chilliwack River valley.

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Section: Biologymentioning

confidence: 99%

“…As is the case with other species of Cimicifuga being investigated for pharmacological value (Shibata et al 1980), C. elata contains active medicinal ingredients. "Black cohosh," as it is known in the herbal trade, is considered one of the most useful medicinal plants of the Pacific Northwest.…”

Section: Limiting Factorsmentioning

confidence: 99%

Status of the Tall Bugbane, Cimicifuga elata (Ranunculacae), in Canada

Penny,

Douglas

1999

The Canadian Field-Naturalist

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“…[11,12] : Based on a systematic review, y evidence of antiproliferative properties of black cohosh but a lack of confirmation from clinical studies for a protective role in cancer studies have reported black cohosh to possess inhibitory effects on estrogen responsive cell lines/breast cancer cells. Furthermore, in a cell line study, relatively low concentrations of actein or the methanol/water fraction of black cohosh may cause synergistic inhibition of human breast cancer cell proliferation when combined with different classes of Acetein may activate genes that respond to DNA damage and unfolded protein responses, and enhance apoptosis and repressed cell in vitro study conducted on human prostate cancer cells with black cohosh extract, the extract killed hormone-responsive or hormone-unresponsive prostate cancer cells by induction of apoptosis and activation of caspases.…”

mentioning

confidence: 99%