Pharmacological studies on zymosan inflammation in rats and mice. 1: Zymosan-induced paw oedema in rats and mice

Tarayre, J P; Delhon, A.; Aliaga, M.; Barbara, M.; Bruniquel, F.; Caillol, V.; Puech, L.; Consul, Nikita; Tisné-Versailles, J

doi:10.1016/1043-6618(89)90155-2

Cited by 33 publications

(12 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To isolate the studies of Cox-2 mRNA stabilization to specific target tissues, a loxP flanked STOP cassette will be used to restrict transgene expression to tissues in which Cre recombinase is expressed. Zymosan or carrageenan injections into the mouse paw provoke inflammatory reactions [60,61]. NSAIDs inhibit edema in both zymosan-and carrageenan-induced inflammation, and Cox-2 mRNA and protein expression has been analyzed in the carrageenan-induced paw inflammation model [62,63].…”

Section: Discussionmentioning

confidence: 99%

Imaging Cyclooxygenase-2 (Cox-2) Gene Expression in Living Animals with a Luciferase Knock-in Reporter Gene

et al. 2006

View full text Add to dashboard Cite

The cyclooxygenase-2 (Cox-2) gene plays a role in a variety of normal and pathophysiological conditions. Expression of the Cox-2 gene is induced in a broad range of cells, in response to many distinct stimuli. The ability to monitor and quantify Cox-2 expression noninvasively in vivo may facilitate a better understanding of the role of Cox-2, both in normal physiology and in different diseases. We generated a "knock-in" mouse in which the firefly luciferase reporter enzyme is expressed at the start site of translation of the endogenous Cox-2 gene. Correlation of luciferase and Cox-2 expression was confirmed in heterozygous Cox-2luc/+ mouse embryonic fibroblasts isolated from the knock-in mouse. In an acute sepsis model, following injection of interferon gamma and endotoxin, ex vivo imaging and Western blotting demonstrated coordinate Cox-2 and luciferase induction in multiple organs. Using both paw and air pouch inflammation models, we can monitor repeatedly localized luciferase expression in the same living mouse. Cox-2luc/+ knock-in mice should provide a valuable tool to analyze Cox-2 expression in many disease models.

show abstract

Section: Discussionmentioning

confidence: 99%

Imaging Cyclooxygenase-2 (Cox-2) Gene Expression in Living Animals with a Luciferase Knock-in Reporter Gene

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Animal models using zymosan as a phlogistic agent have been widely investigated [3]. One of them, the zymosan air-pouch assay in mice, is also frequently used to measure the exudative and proliferative components of inflammation [4].…”

Section: Introductionmentioning

confidence: 99%

Measurement of interleukin-1 liberation in zymosan air-pouch exudate in mice

Erdő¹,

Török²,

Székely³

1994

Agents and Actions

View full text Add to dashboard Cite

The aim of the present study was to examine whether interleukin-1 (IL-1) production is involved in the pathology of inflammation induced by zymosan in the air-pouch of mice. For this reason the IL-1 alpha level was determined in the air-pouch exudate by specific ELISA kit 4, 24, 48 h and 4-8 days after zymosan injection into preformed subcutaneous air-pouches in mice. Concurrently, some conventional parameters such as volume of exudate, its protein content and the total leukocyte count were also measured. The IL-1 alpha level reached its maximum 24 h after zymosan administration and remained elevated throughout the 8-day observation period. Exudation, accumulation of leukocytes and protein also were maximal on day 8. The effects of some anti-inflammatory agents have also been examined. Orally administered dexamethasone induced a dose-dependent reduction in IL-1 alpha, whereas indomethacin and IX 207-887, an IL-1-release inhibitor, failed to reduce the IL-1 alpha content in this model.

show abstract

“…Yeast and zymosan, which is a structural polysaccharide of yeast cell wall, cause an acute inflammatory reaction. Antihistamines, antiserotonins, and lipoxygenase inhibitors prevent these edemas, in which leukotrienes are also involved, whereas cyclooxygenase inhibitors do not [18,19] . Other studies suggest that zymosan is a non-specific irritant which elicits not only an LTB4 response, but also the induction of chemotactic factors C3a & C5a from the activation of the alternative pathway of the complement system [20] , the synthesis of prostaglandins, thromboxanes, and leukotrienes, and the formation and release of plateletactivating factor, free radicals and lysosomal enzymes [19,20] .…”

Section: Discussionmentioning

confidence: 94%

Anti-inflammatory Properties of New Adamantane Derivatives. Design, Synthesis, and Biological Evaluation

Antoniadou-Vyza

Avramidis

Kourounakis

et al. 1998

Arch. Pharm. Pharm. Med. Chem.

View full text Add to dashboard Cite

A series of adamantane‐containing molecules consisting of two lipophilic centers which are linked by different bridges (oxime esters, oxime ethers, amides, and symmetric alcohols), were designed and synthesized as anti‐inflammatory agents. Their anti‐inflammatory activity was evaluated as their ability to inhibit phlogistic‐induced mouse paw edema. Some of the tested compounds exhibited activity comparable to that of diclofenac, others had a weaker activity, while some oxime esters proved to enhance the inflammatory response. In all cases, activity was dose‐dependent. The deacylated compound 10 was found to be the most active of the series, inhibiting inflammation due to Baker’s yeast, the mechanism of which involves mainly the activation of lipoxy‐genase and/or complement systems, a property which is absent from most selective cyclooxygenase only inhibiting non‐steroidal anti‐inflammatory drugs (NSAIDs).

show abstract

Pharmacological studies on zymosan inflammation in rats and mice. 1: Zymosan-induced paw oedema in rats and mice

Cited by 33 publications

References 30 publications

Imaging Cyclooxygenase-2 (Cox-2) Gene Expression in Living Animals with a Luciferase Knock-in Reporter Gene

Imaging Cyclooxygenase-2 (Cox-2) Gene Expression in Living Animals with a Luciferase Knock-in Reporter Gene

Measurement of interleukin-1 liberation in zymosan air-pouch exudate in mice

Anti-inflammatory Properties of New Adamantane Derivatives. Design, Synthesis, and Biological Evaluation

Contact Info

Product

Resources

About