Pharmacological Study of the Anti-ulcer Efficacy of Saraca asoca Leaves Extract in Various Ulcer-inducing Models in Rats

Saxena, Shivangi; Dubey, Vishal; Tiwari, Megha; Yadav, Komal; Kumar, Ashwani; Devi, Shilpi

doi:10.25258/ijpqa.14.4.36

Cited by 1 publication

(1 citation statement)

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“…In the dose of 60 mg/5 mL of millet formulation %inhibition was found to be 16.66% while for millets with glycerine, it was increased to 50% inhibition. [30][31][32][33] Total acidity in the millet with glycerine group was found to be 80 mEq which is less as compared to disease control group and standard group. In order to mimic natural digestion, the millet protein in this study was hydrolyzed using pepsin.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Antiulcer Activity for Selective and Functional Millet using Pylorus Ligation Induced Ulcer in Rat

Vanjari,

Kumbhar

2024

IJPQA

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Although millet has long been thought to have gastroprotective properties, much research does not assess its efficacy as a treatment for stomach ulcers. Currently, medication therapy is the primary clinical treatment for stomach ulcers. Antacids, cytoprotective medicines, proton pump inhibitors (PPI), H2 histamine receptor antagonists have many side effect and poor patient compliance. Hence, inexpensive, easily accessible, and with less negative effects, millets are an excellent and traditional source in the treatment of a variety of diseases like ulcers. In the present research, pearl millet, finger millet and sorghum millet formulation is used and toxicity and antiulcer activity are determined on wistar rats grouped in six different groups consisting of control, disease, standard, millet formulation, glycerin (gly.) vehicles and millet along with glycerin vehicle. After the test item was administered once at a solitary dosage of 2000 mg/kg, none of the treatment group animals showed several clinical indications of toxicity or mortality. In antiulcer activity, ulcer scoring was found to be less in group treated with millet and glycerin than in the diseased group and standard group and %inhibition was also increased in groups treated with millet with glycerine. Total acidity and pepsin estimation was done and these values for the millet group with glycerine were found within limit compared to disease control. The millet and glycerine treatment significantly inhibited lesions associated with stomach ulcers.

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Section: Discussionmentioning

confidence: 98%