Pharmacological study on piperine

Lee, Eun Bang; Shin, Kuk Hyun; Woo, Won Sick

doi:10.1007/bf02856625

Cited by 96 publications

(46 citation statements)

References 5 publications

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Section: -9)mentioning

confidence: 99%

“…10,11) Piperine was the first amide isolated from Piper species and was reported to display central nervous system depression, antipyretic, and anti-inflammatory activity. 12,13) Moreover, previous studies have demonstrated that piperine and its derivatives present sedative-hypnotic, tranquilizing, and muscle-relaxing actions and can intensify the depressive action of other depressants. 14) Based on the aforementioned evidence, it might be suggested that piperine could be useful for the control of CNS-related conditions, including mood disorders and moderate or mild depression states.…”

Section: 2)mentioning

confidence: 99%

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Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity

et al. 2005

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Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamine neurotransmitters such as serotonin, dopamine, and norepinephrine, and appears to play important roles in several psychiatric and neurological disorders. 1,2) MAO has been divided into two subtypes, MAO-A and MAO-B, on the basis of their amino acid sequence, substrate and inhibitor selectivity, and tissue distribution.2-4) MAO-A inhibitors are useful in the therapy of mental disorders, mainly as antidepressants, whereas MAO-B inhibitors are expected to be useful in the therapy of Parkinson's and Alzheimer's disease. 1,5) To date, a number of MAO inhibitors such as coumarins, xanthones, and isoquinoline alkaloids have been isolated from natural products or synthesized. 6-9)Piper longum L. (Piperaceae), a slender aromatic climber, is a native of the Indo-Malayan region and grows wild in the tropical rain forests of India. The extract of the crude drug "Piperis Longi Fructus," the fruits of P. longum, is frequently used in folk medicine to treat bronchial trouble and is used as a carminative and analgesic. 10,11) Piperine was the first amide isolated from Piper species and was reported to display central nervous system depression, antipyretic, and anti-inflammatory activity. 12,13) Moreover, previous studies have demonstrated that piperine and its derivatives present sedative-hypnotic, tranquilizing, and muscle-relaxing actions and can intensify the depressive action of other depressants.14) Based on the aforementioned evidence, it might be suggested that piperine could be useful for the control of CNS-related conditions, including mood disorders and moderate or mild depression states.In the present work, we have investigated the activityguided isolation and inhibitory effect of piperine on MAO activity in mouse brain. We also investigate the antidepressant-like activity of piperine in the in vivo tail suspension test. Results and DiscussionIn our ongoing search for naturally occurring MAO inhibitors, an ethanol extract of the fruits of P. longum exhibited strong inhibitory activity on mouse brain MAO. A bioassay-guided isolation of the extract yielded a known piperidine alkaloid, piperine, as an active component. The structure was identified by physicochemical and spectroscopic methods (mp, UV, IR, MS, 1 H-and 13 C-NMR) and by comparing the data obtained with those of published values (Fig. 1). 15,16) Piperine exhibited 38.0% inhibition of MAO activity at 8 mM, with an IC 50 value of 11.1 mM, which is comparable to iproniazid as a positive control (Table 1). According to the kinetic properties of MAO from the mouse brain, the values of K m and V max by using kynuramine were 72.2Ϯ5.60 mM and 3.97Ϯ0.18 nmol/min/mg protein, respectively (nϭ3) (data not shown).In order to verify the selectivity of the MAO activity, l-deprenyl-pretreated MAO preparation was used for the measurement of MAO-A activity, whereas a clorgyline-pretreated preparation was used for MAO-B. This result indicated that

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Section: -9)mentioning

confidence: 99%

Section: 2)mentioning

confidence: 99%

Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity

et al. 2005

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“…In this review, 174 references were cited. Lee et al, 1984Munjudar et al, 1990 Riparin I Kocialski et al, 1972Kaplan et al, 1967Omaye et al, 1972 Lupanine, 17 oxo …”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory activity of alkaloids: a twenty-century review

Barbosa-Filho¹,

Piuvezam²,

Moura³

et al. 2006

Rev. bras. farmacogn.

170

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RESUMO: "Atividade anti-infl amatória de alkalóides: Uma revisão do século XX". Muitas substâncias que interferem na resposta infl amatória têm sido isoladas de plantas. Esta revisão mostra alguns alcalóides de origem vegetal que no período de 1907-2000 foram avaliados quanto a uma possível atividade anti-infl amatória. Os alcalóides foram classifi cados em subgrupos de acordo com suas estruturas químicas e os dados farmacológicos foram obtidos de diferentes modelos experimentais. Dos 171 alcalóides avaliados, 137 apresentaram atividade anti-infl amatória, e, entre eles, os alcalóides do tipo isoquinolínicos foram os mais estudados. O modelo de edema de pata induzido por carragenina foi o mais empregado para avaliação da atividade anti-infl amatória. Nesta revisão 174 referências foram consultadas. Unitermos: Alcalóides, atividade anti-infl amatória, infl amação, modelos experimentais.ABSTRACT: Many substances which interfere with the infl ammatory response have been isolated from plants. This review shows some alkaloids of vegetal origin which in the period of 1907 to 2000 were evaluated regarding a possible anti-infl ammatory activity. The alkaloids were classifi ed in sub-groups in accordance with their chemical structures and the pharmacological data were obtained from different experimental models. Of the 171 evaluated alkaloids, 137 presented anti-infl ammatory activity, and among those, the isoquinoline type was the most studied. The Carrageenin-induced paw edema was the most used model for evaluating the anti-infl ammatory activity. In this review, 174 references were cited.

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“…There are many other terpenoids like pinene, sabinene, limonene, caryophyllene and linalool that contributes to the medicinal properties of the plant. These compounds can have varying pharmacological effects including anti-fertility (Vladimirov et al, 1991), anti-inflammatory (Lee et al, 1984), bioavailability of drugs (Allameh et al, 1992; Khajuria et al, 2002), stimulation of release of epinephrine (Kawada et al, 1988) and elevation of levels of circulating thyroid hormones (Tripathi & Tripathi, 1989). Because of the presence of these kinds of diverse metabolites, the microbes that live inside the plant as endophytes can also expected to have same or similar or novel compounds with superior biological effects.…”

Section: Introductionmentioning

confidence: 99%

Exploration of Actinomycetes Endophytically Associated With Piper Nigrum for Potential Bioactivity

Jasim¹,

Rajappan²,

Mathew³

et al. 2015

J microb biotech food sci

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Piper nigrum is well known for its metabolite richness. So endophytic microorganisms that reside within such environments can be expected to have promising biosynthetic potential. The current study identified three endophytic actinomycetes with broad bioactivity which can have applications in natural product related pharmacological research. The Verrucosispora sp identified in the study was found to have promising anticancer and antimicrobial activities and Streptomyces sp. was found to have antioxidant activity. The results obtained are supported by many previous reports and this suggests the isolates obtained in the study to have the possible presence of potential known or novel compounds with broad spectrum of activity.

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Pharmacological study on piperine

Cited by 96 publications

References 5 publications

Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity

Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity

Anti-inflammatory activity of alkaloids: a twenty-century review

Exploration of Actinomycetes Endophytically Associated With Piper Nigrum for Potential Bioactivity

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