Pharmacological therapy in the management of temporomandibular disorders and orofacial pain: a systematic review and meta-analysis

Minervini, Giuseppe; Franco, Rocco; Crimi, Salvatore; Di Blasio, Marco; D’Amico, Cesare; Ronsivalle, Vincenzo; Cervino, Gabriele; Bianchi, Alberto; Cicciù, Marco

doi:10.1186/s12903-023-03524-8

Cited by 7 publications

(1 citation statement)

References 54 publications

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“…Pharmacological agents commonly employed in TMD treatments encompass NSAIDs, opioids, CCS, muscle relaxants, antidepressants, anticonvulsants, and benzodiazepines [ 28 , 47 , 62 , 69 , 82 , 84 , 85 , 98 , 99 , 100 , 101 , 102 ]. Regarding pain management in TMDs, some evidence suggests that NSAIDs can be considered as an initial approach for alleviating joint and muscle pain in TMD patients [ 99 , 100 ].…”

Section: Resultsmentioning

confidence: 99%

Temporomandibular Disorders Management—What’s New? A Scoping Review

Mauro,

Verdecchia,

Suárez-Fernández

et al. 2024

Dentistry Journal

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Temporomandibular disorders include various conditions that impact the masticatory system, affecting its structure, function, or physiology. Clinicians face a complex array of therapeutic options when treating this group of diseases, emphasizing the importance of evaluating the current evidence to guide decisions in patient care. The main objective of this article is to conduct a scoping review on the available treatment approaches to manage temporomandibular disorders (TMDs). An extensive search of the literature was performed on Scopus, Pubmed, Embase, and Web of Science. Systematic reviews published in the last 5 years were considered. Out of the 2183 publications identified, 109 studies were included in this review. Among them, 39 articles focused on the non-invasive approach, while 120 delved into the minimally invasive approach, and 15 explored the surgical approach. Non-invasive or conservative approaches like cognitive-behavioral therapy, physical therapy, and acupuncture offer effective pain management and functional improvements in TMDs. Emerging treatments offer promising alternatives for treating these disorders. Surgery should be reserved for severe cases, with conservative therapies used in conjunction with invasive procedures for optimal patient outcomes.

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Section: Resultsmentioning

confidence: 99%

Temporomandibular Disorders Management—What’s New? A Scoping Review

Mauro,

Verdecchia,

Suárez-Fernández

et al. 2024

Dentistry Journal

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Modern Approaches to the Treatment of Acute Facial Pain

Asadauskas,

Luedi,

Urman

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Acute facial pain presents a complex challenge in medical practice, requiring a comprehensive and interdisciplinary approach to its management. This narrative review explores the contemporary landscape of treating acute facial pain, delving into pharmacological, non-pharmacological, and advanced interventions. The significance of tailored treatment strategies, rooted in the diverse etiologies of facial pain, such as dental infections, trigeminal neuralgia, temporomandibular joint disorders, sinusitis, or neurological conditions like migraines or cluster headaches, is underscored. We particularly emphasize recent advances in treating trigeminal neuralgia, elucidating current treatment concepts in managing this particular acute facial pain. Recent Findings Recent research sheds light on various treatment modalities for acute facial pain. Pharmacotherapy ranges from traditional NSAIDs and analgesics to anticonvulsants and antidepressants. Non-pharmacological interventions, including physical therapy and psychological approaches, play pivotal roles. Advanced interventions, such as nerve blocks and surgical procedures, are considered in cases of treatment resistance. Moreover, we explore innovative technologies like neuromodulation techniques and personalized medicine, offering promising avenues for optimizing treatment outcomes in acute facial pain management. Summary Modern management of acute facial pain requires a nuanced and patient-centric approach. Tailoring treatment strategies to the individual's underlying condition is paramount. While pharmacotherapy remains a cornerstone, the integration of non-pharmacological interventions is essential for comprehensive care. Advanced interventions should be reserved for cases where conservative measures prove inadequate. Furthermore, leveraging innovative technologies and personalized medicine holds promise for enhancing treatment efficacy. Ultimately, a holistic approach that considers the diverse needs of patients is crucial for effectively addressing acute facial pain.

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Multi-material 3D printing of functionally graded soft-hard interfaces for enhancing mandibular kinematics of temporomandibular joint replacement prostheses

Moosabeiki,

Khan,

Cruz Saldivar

et al. 2024

Commun Mater

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Temporomandibular joint (TMJ) replacement prostheses often face limitations in accommodating translational movements, leading to unnatural kinematics and loading conditions, which affect functionality and longevity. Here, we investigate the potential of functionally graded materials (FGMs) in TMJ prostheses to enhance mandibular kinematics and reduce joint reaction forces. We develop a functionally graded artificial cartilage for the TMJ implant and evaluate five FGM designs: hard, hard-soft, and three FGM gradients with gradual transitions from 90% hard material to 0%, 10%, and 20%. These designs are 3D printed, mechanically tested under quasi-static compression, and simulated under physiological conditions. Results from computational modeling and experiments are compared to an intact mandible during incisal clenching and left group biting. The FGM design with a transition from 90% to 0% hard material improves kinematics by 19% and decreases perfomance by 3%, reduces joint reaction forces by 8% and 10%, and increases mandibular movement by 20% and 88% during incisal clenching and left group biting, respectively. These findings provide valuable insights for next-generation TMJ implants.

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Pharmacological therapy in the management of temporomandibular disorders and orofacial pain: a systematic review and meta-analysis

Cited by 7 publications

References 54 publications

Temporomandibular Disorders Management—What’s New? A Scoping Review

Temporomandibular Disorders Management—What’s New? A Scoping Review

Modern Approaches to the Treatment of Acute Facial Pain

Multi-material 3D printing of functionally graded soft-hard interfaces for enhancing mandibular kinematics of temporomandibular joint replacement prostheses

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