Pharmacological therapy of white muscle disease in lambs with selenium preparations in a comparative aspect

Abstract

In the course of the experiment on the comparative assessment of selenium-containing preparations selephlan and plexomin Se-2000 in the treatment of white muscle disease in young sheep, it was determined that selephlan has a more pronounced effect on the clinical and physiological state and intestinal biocenosis of lambs, their morphological and biochemical blood parameters, as well as the level of antioxidant protection of the body of animals. Under the influence of the preparation, the erythro- and hematopoiesis is activated in lambs, as well as the normalization of biochemical blood homeostasis. The level of enzymatic activity (AST, ALT, ALP, LDH) significantly decreases in 1.36 (p≤0.05); 1.71 (p≤0.001); 1.21 (p≤0.05) and 1.3 (p≤0.01) times, while the concentration of carotene increases in 3.1 times, vitamin E increases in 1.73 times and vitamin A increases by 26.8%. Selephlan helps to reduce the concentration of DC by 21.8%, KD – by 28.7%, MDA – in 1.61 (p <0.05) times.

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

“…Defisiensi salah satu atau kedua komponen nutrisi tersebut dapat menyebabkan berbagai macam penyakit seperti white muscle disease (Delesalle et al, 2017), retensi plasenta (Jovanović et al, 2013), oksidasi susu (Baiomy & Suliman, 2012), penurunan fungsi kekebalan tubuh (Shrimali et al, 2008) dan mastitis (Khan et al, 2022). Hasil penelitian Delesalle et al, (2017) dan Semenenko et al (2021) menunjukkan bahwa defisiensi Se dapat mengakibatkan white muscle disease. Radostits et al (2000) menambahkan bahwa penyakit tersebut disebabkan oleh defisiensi vitamin E atau kombinasi defisiensi Se dan vitamin E. Gejala klinis white muscle disease yang sering dijumpai adalah kekakuan, kelemahan, degenerasi otot dan posisi berbaring lateral (Radostits et al, 2000;Abutarbush and Radostits, 2003).…”

Effects of different levels of nano-selenium on growth performance, antioxidant capacity, biochemical parameters, and selenium content in Landes geese

“…Selenium (Se) is a basic trace element in animals and humans. The dietary shortage of Se might lead to white muscle disease (Bakhshalinejad et al, 2018;Semenenko et al, 2021), low glutathione peroxidase (GSH-Px) (Silva et al, 2021), and reproduction inefficiency (Hemingway et al, 2003). Selenium has many physiologically relevant regulatory functions such as maintaining normal immunity, reducing free radicals, and improving growth performance (Li et al, 2021;Nemati et al, 2021).…”