Pharmacological Treatment of Acute Spinal Cord Injuries In The Light Of Recent Developments

Abstract

Spinal injuries represent a significant public health issue with both individual and societal implications due to its potential to result in long-term or permanent disability and death. Today, notwithstanding the comprehensive elucidation of the mechanism of injury in its all aspects and breakthroughs in early diagnosis techniques and treatment, spinal injuries still retain their devastating nature. Although many agents hypothesized to possess neuroprotective and neuroregenerative properties have been demonstrated to be effective in the experiments, research involving human subjects is still in progress, offering promising developments. Methylprednisolone at a high dose is the most extensively investigated therapeutic for acute spinal injuries. Despite significant controversy, it remains a viable treatment option. It is anticipated that combining stem cell transplantation with multiple pharmacological agents will yield more favorable outcomes.