2020
DOI: 10.1007/s40263-020-00711-x
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Pharmacological Treatment of Methamphetamine/Amphetamine Dependence: A Systematic Review

Abstract: Background Stimulant drugs are second only to cannabis as the most widely used class of illicit drug globally, accounting for 68 million past-year consumers. Dependence on amphetamines (AMPH) or methamphetamine (MA) is a growing global concern. Yet, there is no established pharmacotherapy for AMPH/MA dependence. A comprehensive assessment of the research literature on pharmacotherapy for AMPH/MA dependence may inform treatment guidelines and future research directions. Methods We systematically reviewed the pe… Show more

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Cited by 143 publications
(161 citation statements)
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References 78 publications
(179 reference statements)
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“…The U.S. Food and Drug Administration (FDA) has only approved medications for the treatment of alcohol [8], nicotine [9], and opioid abuse [10]; none for multiple drug use [5]. Treatments against the abuse of other drugs have been shown to be ineffective [11] or inconclusive [12]. The first line of treatment against alcohol abuse, naltrexone, and acamprosate, only moderately reduces alcohol drinking, as shown in a subset of studies [13].…”
Section: Drug Abuse and Current Treatmentsmentioning
confidence: 99%
“…The U.S. Food and Drug Administration (FDA) has only approved medications for the treatment of alcohol [8], nicotine [9], and opioid abuse [10]; none for multiple drug use [5]. Treatments against the abuse of other drugs have been shown to be ineffective [11] or inconclusive [12]. The first line of treatment against alcohol abuse, naltrexone, and acamprosate, only moderately reduces alcohol drinking, as shown in a subset of studies [13].…”
Section: Drug Abuse and Current Treatmentsmentioning
confidence: 99%
“…There was also a signi cant decrease in MA craving, as well as subjective rating of drug e cacy, supporting the utility of larger trials of LDX for this population. The high proportion of participants (n=14 [87.5%]) to complete the protocol to the highest dose is also promising, given studies in this population are typically challenged by low recruitment and low retention (8).…”
Section: Discussionmentioning
confidence: 99%
“…Severity of Dependence Scale (Median [IQR]) 11 (8)(9)(10)(11)(12) 11 (8-12) ---11 (10)(11)(12) 11 (9)(10)(11)(12) Drug Change in days of methamphetamine use…”
mentioning
confidence: 99%
“…7,20 Clinical trials examining dopaminergic agents, serotonergic agents, g-aminobutyric acid agents, glutamatergic agents, cholinesterase inhibitors, benzoquinolizine derivatives, opioid agents, and nicotinic agents have been observed with varying results in regards to their effects on METH users. 7,13,21 Dopamine agonists, modafinil [22][23][24][25][26] and bupropion, [27][28][29][30][31][32][33][34] have demonstrated beneficial responses in METH-dependent patients, while naltrexone, [35][36][37][38][39] an opioid antagonist, seemed to reduce amphetamine's reinforcement effects. Despite the promising start, naltrexone revealed conflicting results with some studies showing no differences in METH use between treatment and placebo groups.…”
Section: Introductionmentioning
confidence: 99%