Pharmacological treatment of obesity in children and adolescents: current status and perspectives

Catoira, Natalia; Nagel, Mara; Girolamo, Guillermo Di; Gonzalez, Claudio

doi:10.1517/14656566.2010.512005

Cited by 11 publications

(4 citation statements)

References 52 publications

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“…In the treatment of pediatric obesity, metformin has become a popular choice since its effectiveness, safety and multiple metabolic and cardiovascular benefits [5,6]. …”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

et al. 2013

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Objective: Childhood obesity has become epidemic and has been accompanied by an increase in prevalence of type 2 diabetes (T2DM) in youth. Addressing obesity and insulin resistance by drug treatment represents a rational strategy for the prevention of T2DM. A systematic review was performed to evaluate the effectiveness of metformin in reducing weight and ameliorating insulin resistance in obese nondiabetic children. Methods: A PubMed database search was conducted, using ‘metformin', ‘obesity', ‘insulin resistance', ‘children', ‘adolescents' as search terms. Results: Eleven trials were included in the present review. Metformin was administered for 6-12 months at a dosage of 1,000-2,000 mg/daily, decreasing BMI by 1.1-2.7 compared with placebo or lifestyle intervention alone. Concomitantly, fasting insulin resistance improved after metformin therapy. Posttreatment follow-up was performed in one study, showing that after 1 year of discontinuation of therapy the decrease in BMI disappears. Conclusions: Short-term metformin treatment appears to moderately affect weight reduction in severely obese children and adolescents, with a concomitant improvement in fasting insulin sensitivity. Further studies with longer treatment period are needed to establish how much metformin can reduce weight and its real utility in preventing T2DM development in pediatric patients.

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“…In the treatment of pediatric obesity, metformin has become a popular choice since its effectiveness, safety and multiple metabolic and cardiovascular benefits [5,6]. …”

Section: Introductionmentioning

confidence: 99%

Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

et al. 2013

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“…Studies show that BMI varies significantly with ages for children ( 70 ), measuring metabolic status by adopting a composite measures of BMI, waist-to-hip ratio, gender, genetic ethnicity, and metabolic markers may be of greater value in risk stratification of obesity ( 71 ). The etiology of obesity involves a variety of factors including genetic, epigenetic, environmental, dietary and lifestyle habits, and endocrine disorders ( 72 ), the molecular basis of which has not been fully elucidated ( 73 ). Adiponectin, leptin and plasminogen activator inhibitor 1 can be used as biomarkers to predict metabolic syndrome among adolescents ( 74 ).…”

Section: Discussionmentioning

confidence: 99%

“…Olistat is currently the only approved drug for obese adolescents over 12 years old. It is limited in use with metformin, sibutramine and exenatide due to side effects of treatment ( 64 , 72 ).…”

Section: Discussionmentioning

confidence: 99%

A visualized and scientometric analysis of research trends of weight loss in overweight/obese children and adolescents (1958–2021)

Sun

Li²,

Zhang³

2022

Front. Public Health

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BackgroundWeight loss is an appropriate approach to reduce the health risks associated with overweight/obese children and adolescents, and the optimal method of weight loss requires further research. This study systematically explores scientific co-operation, disciplinary interaction, hotspots and trends in the field of weight loss in overweight/obese children and adolescents (WLOCA), and provides references for further research.MethodsCitespace 5.8.R1 (64-bit) was adopted to conduct a comprehensive visualization analysis of the literature on WLOCA from Web of Science Core Collection, including publication, institution, country/region, author, journal, keywords and reference.Results2,513 papers were found in the Web of Science Core Collection, and the annual number of papers published has increased significantly since 2003. Cincinnati Children's Hospital is the institution with the largest number of publications, while Washington University plays a pivotal role in the collaboration network. In terms of nations, USA has made greater contributions than the rest in terms of the number of publications and global co-operation research. The most influential authors in this field are Thomas H. Inge, Thomas Reinehr, Todd M. Jenkins, Epstein LH, Ogden CL, etc. The most active journals are “Obesity,” “International Journal of Obesity,” “Obesity Surgery,” “Pediatrics,” etc. which are characterized by interdisciplinary interactions. Research hot topics mainly include “assessment of obesity and pathophysiological mechanism,” “comprehensive intervention,” and “bariatric surgery,” and there's a gradual shift from “lifestyle intervention” and “pathophysiological mechanism” to “clinical surgical application.” In addition, disciplinary integration and comprehensive research, targeted intervention and treatment, and prospective research are the future research trends.ConclusionThe overall trend in WLOCA study is positive. The main contribution of this study is to reveal the overall picture of the research in this field with visual maps and detailed data by combining quantitative with qualitative approaches, which can provide valuable references for relevant researchers to quickly understand the status of studies on WLOCA, to seek co-operation, and grasp research hotspots and frontier trends.

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“…Studies of “real-life” clinics show younger children and those with lower levels of obesity tend to achieve more clinically-meaningful weight loss while weight stabilization or maintenance appears to be a more realistic goal for older children and those with higher levels of obesity [34–36]. Improvements in obesity status are equally modest when lifestyle and behavioral interventions are supplemented by pharmacotherapy [37, 38]. Increasing evidence supports a role for bariatric surgery in managing SO, with substantial weight loss accompanied by improved cardiometabolic and psychosocial indicators [39], but the availability and long term evidence of pediatric surgical interventions is limited [40].…”

Section: Introductionmentioning

confidence: 99%

The Team to Address Bariatric Care in Canadian Children (Team ABC3): Team Grant Research Proposal

Abc

2017

BMC Res Notes

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Pharmacological treatment of obesity in children and adolescents: current status and perspectives

Cited by 11 publications

References 52 publications

Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

Systematic Review of Metformin Use in Obese Nondiabetic Children and Adolescents

A visualized and scientometric analysis of research trends of weight loss in overweight/obese children and adolescents (1958–2021)

The Team to Address Bariatric Care in Canadian Children (Team ABC3): Team Grant Research Proposal

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