Pharmacological Treatments for Worry: Focus on Generalised Anxiety Disorder

Anderson, Ian M.; Palm, Marisha E.

doi:10.1002/9780470713143.ch18

Cited by 8 publications

(4 citation statements)

References 79 publications

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“…Psychotropic medications and cognitive behavior therapy (CBT) both appear to be effective for treating GAD (Anderson & Palm, 2006;Borkovec & Ruscio, 2001;Fisher, 2006). However, response rates are inconsistent across studies.…”

Section: The Evolution Of Gad and Its Treatmentmentioning

confidence: 98%

“…However, response rates are inconsistent across studies. Current evidence suggests that pharmacotherapy may be effective at reducing symptoms of anxiety but does not appear to have a significant impact on worry (Anderson & Palm, 2006), the defining characteristic of GAD. Clinical trials have indicated that CBT is an efficacious treatment relative to pill placebo, no treatment, wait-list, and nondirective supportive therapy, and that improvements from CBT are maintained 1 year post-therapy (Borkovec & Ruscio, 2001;Gould, Safren, Washington, & Otto, 2004).…”

Section: The Evolution Of Gad and Its Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications

Behar

DiMarco

Hekler

et al. 2009

Journal of Anxiety Disorders

411

296

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Section: The Evolution Of Gad and Its Treatmentmentioning

confidence: 98%

Section: The Evolution Of Gad and Its Treatmentmentioning

confidence: 99%

Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications

Behar

DiMarco

Hekler

et al. 2009

Journal of Anxiety Disorders

411

296

View full text Add to dashboard Cite

“…Panic Disorder w/agoraphobia was originally named in DSM III in 1980 following research in the USA described as “pharmacodissection” using the NET inhibitor imipramine (26). Recent studies show benefits for norepinephrine and serotonin reuptake inhibitors in treatment of panic agoraphobia (27, 28), Social Anxiety Disorder (29), Generalized Anxiety Disorder (30), and Post Traumatic Stress Disorder (31). …”

Section: Clinical Benefits: Demonstration Of the Medical Roles Ofmentioning

confidence: 99%

Monoamine Transporters

Lin¹,

Canales²,

Björgvinsson³

et al. 2011

Progress in Molecular Biology and Translational Science

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Transporters of dopamine, serotonin and norepinephrine have been empirically used as medication targets for several mental illnesses for the last decades. These protein-targeted medications are effective only for subpopulations of patients with transporter-related brain disorders. Since the cDNA clonings in early 1990’s, molecular studies of these transporters have revealed a wealth of information about the transporters’ structure activity relationship (SAR), neuropharmacology, cell biology, biochemistry, pharmacogenetics and the diseases related to the human genes encoding these transporters among related regulators. Such new information creates a unique opportunity to develop transporter-specific medications based on SAR, mRNA, DNA and perhaps transporter trafficking regulation, for a list of highly relevant diseases including substance abuse, depression, schizophrenia and Parkinson’s disease.

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“…However, these effects can vary considerably from person to person, and many people with anxiety disorders or who are taking antidepressants are able to perform well in cognitive tasks. In addition, it is crucial to keep in mind that cognitive behavioral therapies can assist individuals in managing anxiety and enhancing cognitive control, thereby potentially compensating for some of these cognitive difficulties [40].…”

Section: Empirical Studiesmentioning

confidence: 99%

Neuropsychology of Generalized Anxiety Disorder in Clinical Setting: A Systematic Evaluation

Gkintoni,

Ortiz

2023

Healthcare

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This research paper provides a systematic review of the neuropsychology of generalized anxiety disorder (GAD), examining relevant articles’ methodologies and subject matter and highlighting key findings. It suggests potential cognitive deficits in GAD patients, such as subtle attention, executive function, and working memory deficiencies. It also discusses neural correlates of GAD, particularly the hyperactivity in the amygdala and insula, and the additional impact of comorbidity with other psychiatric disorders. The paper uses the PRISMA methodology and draws data from the PsycINFO, Scopus, PubMed, and Elsevier databases. Although the reviewed research has contributed to understanding GAD’s cognitive and neural mechanisms, further research is required. Additionally, the paper mentions the clinical neuropsychology of GAD, including strategies and treatments, such as cognitive behavioral therapy (CBT), mindfulness, and medication. Lastly, the review identifies the limitations of the existing research and recommends future directions to enhance the understanding of GAD’s underlying cognitive and neural mechanisms. The neural underpinnings of GAD encompass heightened activity within the amygdala and insula, which are brain regions implicated in processing adverse emotional reactions. Co-occurring psychiatric disorders, such as major depressive disorder (MDD), can also impact neuropsychological functioning. Additional investigation is warranted to better understand the intricate interplay between GAD, cognitive performance, and underlying neural processes.

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Pharmacological Treatments for Worry: Focus on Generalised Anxiety Disorder

Cited by 8 publications

References 79 publications

Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications

Current theoretical models of generalized anxiety disorder (GAD): Conceptual review and treatment implications

Monoamine Transporters

Neuropsychology of Generalized Anxiety Disorder in Clinical Setting: A Systematic Evaluation

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