2014
DOI: 10.1176/appi.ajp.2013.13040458
|View full text |Cite
|
Sign up to set email alerts
|

Pharmacological Treatments of Non-Substance-Withdrawal Delirium: A Systematic Review of Prospective Trials

Abstract: These promising results warrant further study with consideration of the methodological weaknesses and inconsistencies of studies to date.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

3
41
0
2

Year Published

2014
2014
2019
2019

Publication Types

Select...
5
4

Relationship

1
8

Authors

Journals

citations
Cited by 59 publications
(46 citation statements)
references
References 67 publications
3
41
0
2
Order By: Relevance
“…Delirium's pathogenic pathways are unclear, and up to date, there are no effective therapeutic strategies to treat delirium. A recent systematic review showed that delirium prevention had greater success than treating delirium once it has developed [5]. Haloperidol and second-generation antipsychotics are the most commonly used pharmacological agents with sedative effects for delirium prevention [5].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Delirium's pathogenic pathways are unclear, and up to date, there are no effective therapeutic strategies to treat delirium. A recent systematic review showed that delirium prevention had greater success than treating delirium once it has developed [5]. Haloperidol and second-generation antipsychotics are the most commonly used pharmacological agents with sedative effects for delirium prevention [5].…”
Section: Introductionmentioning
confidence: 99%
“…A recent systematic review showed that delirium prevention had greater success than treating delirium once it has developed [5]. Haloperidol and second-generation antipsychotics are the most commonly used pharmacological agents with sedative effects for delirium prevention [5]. However, these treatments have been shown to cause prolonged QT intervals and extrapyramidal symptoms that increase the risk of fatal cardiovascular incidents [6].…”
Section: Introductionmentioning
confidence: 99%
“…12,13 Also, the use of haloperidol to prevent delirium in frail elderly patients has been advocated in recent years, and tested in trials. 14 In general, the study period of trials is too short and the number of participants too small to detect infrequent adverse events such as deaths. However, the observational studies have suggested that deaths due to conventional antipsychotic use are rather common during the first 180 days of use (4.2%e7.3% of users), 3 and the relative risk of dying is highest in the first month when compared with atypical antipsychotics.…”
mentioning
confidence: 99%
“…Significant delirium prevention effects are associated with haloperidol and second generation antipsychotic medication 45. There are also reports of fascia iliaca nerve block, perioperative gabapentin, melatonin, and a single dose of ketamine during anesthetic induction 45. In mechanically ventilated patients early studies suggest dexmedetomidine may be superior to other sedation strategies 46,47…”
Section: Deliriummentioning
confidence: 99%